(4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester
- CAS No.
- 454185-98-9
- Chemical Name:
- (4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester
- Synonyms
- Methyl 2-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate;methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-;(4-Methoxycarbonylmethylphenyl)boronic acid picol ester;Methyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);[4-(Methoxycarbonyl)methyl]benzeneboronicacidpinacolester;(4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester;(4-Methoxycarbonylmethyl)Phenylboronic Acid Pinacol Ester,>98%;methyl 2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate;(4-Methoxycarbonylmethylphenyl) boronic acid pinacol ester - [M12474];Methyl [4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate
- CBNumber:
- CB02457686
- Molecular Formula:
- C15H21BO4
- Molecular Weight:
- 276.14
- MDL Number:
- MFCD09997797
- MOL File:
- 454185-98-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 41-45 °C |
|---|---|
| Boiling point | 363.0±25.0 °C(Predicted) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| color | White to Orange to Green |
| CAS DataBase Reference | 454185-98-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P280 |
| HS Code | 2931900090 |
(4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3236 | Methyl 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate | 454185-98-9 | 1G | $50 | 2026-04-30 | Buy |
| TCI Chemical | M3236 | Methyl 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate | 454185-98-9 | 5G | $175 | 2026-04-30 | Buy |
| Apolloscientific | OR310403 | [4-(Methoxycarbonyl)methyl]benzeneboronic acid pinacol ester >98.0% | 454185-98-9 | 1g | $82 | 2026-06-04 | Buy |
| Apolloscientific | OR310403 | [4-(Methoxycarbonyl)methyl]benzeneboronic acid pinacol ester >98.0% | 454185-98-9 | 5g | $268 | 2026-06-04 | Buy |
| AK Scientific | AMTB772 | (4-Methoxycarbonylmethyl)phenylboronic acid pinacol ester 95% | 454185-98-9 | 1g | $16 | 2026-06-04 | Buy |
(4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester Chemical Properties, Uses, Production
Uses
(4-Methoxycarbonylmethyl)phenylboronic acid pinacol ester
Synthesis
41841-16-1
73183-34-3
454185-98-9
To a 200 mL round-bottomed flask equipped with a magnetic stirrer was sequentially added [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (0.799 g, 1.09 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bis(1,3,2-dioxaborolane) (bis(boronic acid pinacol ester), 6.65 g 26.2 mmol) and potassium acetate (4.28 g, 43.7 mmol). 1,4-dioxane (100 mL) was added to dissolve the above solid mixture. The flask was sealed, evacuated and displaced three times with nitrogen to exclude oxygen. Methyl 2-(4-bromophenyl)acetate (5.00 g, 21.8 mmol) was then added. The reaction mixture was heated to 70 °C and kept stirring for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into saturated brine to separate the organic and aqueous phases. The aqueous phase was extracted with ethyl acetate (3 x 125 mL), the organic phases were combined and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was purified by fast column chromatography with an eluent gradient of 0-30% ethyl acetate/hexane to afford methyl 4-boronic acid pinacol ester phenylacetate as a colorless, clear liquid (4.93 g, 70% yield). The product was confirmed by NMR hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ 7.68-7.58 (m, 2H), 7.35-7.23 (m, 2H), 3.71 (s, 2H), 3.61 (s, 3H), 1.29 (s, 12H); NMR carbon spectrum (13C NMR, 101 MHz, DMSO-d6) δ 171.29, 137.72, 134.45, 128.86, 83.56, 82.79, 51.68, 40.23, 24.62; mass spectrum (EIMS) m/z 276 ([M]+).
References
[1] Patent: WO2006/46593, 2006, A1. Location in patent: Page/Page column 180-181
[2] Patent: WO2006/109633, 2006, A1. Location in patent: Page/Page column 155-156
[3] Chemical Communications, 2015, vol. 51, # 77, p. 14505 - 14508
[4] Journal of Organic Chemistry, 2006, vol. 71, # 15, p. 5594 - 5598
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 45, p. 12077 - 12080
(4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from (4-Methoxycarbonylmethylphenyl)boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-26 | (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER
454185-98-9
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- (4-METHOXYCARBONYLMETHYLPHENYL)BORONIC ACID PINACOL ESTER
454185-98-9
- $1.00
- 99%
- Career Henan Chemical Co
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