N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
![N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Structure](CAS/GIF/315703-52-7.gif)
- CAS No.
- 315703-52-7
- Chemical Name:
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Synonyms
- JK 184;CS-2369;JK184 (JK-184;JK184, 10 mM in DMSO;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184, Hedgehog signaling inhibitor;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
- CBNumber:
- CB02485085
- Molecular Formula:
- C19H18N4OS
- Molecular Weight:
- 350.44
- MDL Number:
- MFCD01044465
- MOL File:
- 315703-52-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
|---|---|
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light brown |
| InChI | 1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22) |
| InChIKey | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 373385 | Hh Signaling Antagonist VII, JK184 | 315703-52-7 | 5mg | $140 | 2023-01-07 | Buy |
| TCI Chemical | J0041 | JK 184 | 315703-52-7 | 50MG | $225 | 2026-04-30 | Buy |
| Cayman Chemical | 15265 | JK 184 ≥99% | 315703-52-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 15265 | JK 184 ≥99% | 315703-52-7 | 5mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 15265 | JK 184 ≥99% | 315703-52-7 | 10mg | $120 | 2026-04-30 | Buy |
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties, Uses, Production
Uses
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]
Uses
JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.
Biological Activity
Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .
in vivo
JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability[1].
storage
+4°C
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Chengdu NoVi Biotechnology Co., Ltd. | 028-81458053 | novibiotech@163.com sales@novi-biotech.com | China | 226 | 55 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 |
View Latest Price from N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | JK184
315703-52-7
|
$30.00-94.00 | 99.09% | 10g | TargetMol Chemicals Inc. | ||
![N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/8808d044-ab61-4038-8e83-ac7dda903f2c.jpg) |
2019-12-26 | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
315703-52-7
|
$1.00 | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
-
- JK184
315703-52-7
- $30.00-94.00
- 99.09%
- TargetMol Chemicals Inc.
-
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
315703-52-7
- $1.00
- 97%-99.9%
- Career Henan Chemical Co
