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Ipragliflozin

Ipragliflozin structure

CAS No.: 761423-87-4

Chemical Name:: Ipragliflozin

Synonyms: Suglat;CS-1580;Igliazine;Yigelejing;Ipraglifozin;Ipragliflozin;Iprag iflozin;Ipragliflozin-002;Iglienet free base;Ipragliflozin, >=98%

CBNumber:: CB02589633

Molecular Formula:: C21H21FO5S

Molecular Weight:: 404.45

MDL Number:: MFCD19443744

MOL File:: 761423-87-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

Product description	Number	Pack Size	Price
Ipragliflozin	I1284	200MG	$71
Ipragliflozin	I1284	1G	$246
Ipragliflozin ≥98%	22287	10mg	$36
Ipragliflozin ≥98%	22287	50mg	$153
Ipragliflozin ≥98%	22287	100mg	$219
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Ipragliflozin Properties

Melting point	155-157°C
Boiling point	628.8±55.0 °C(Predicted)
Density	1.452
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.27±0.70(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1/C21H21FO5S/c22-15-6-5-12(21-20(26)19(25)18(24)16(10-23)27-21)7-13(15)9-14-8-11-3-1-2-4-17(11)28-14/h1-8,16,18-21,23-26H,9-10H2/t16-,18-,19+,20-,21+/s3
InChIKey	AHFWIQIYAXSLBA-OPUVIHLBNA-N
SMILES	O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1C1C=CC(F)=C(CC2=CC3C=CC=CC=3S2)C=1 \|&1:1,4,6,8,10,r\|
FDA UNII	3N2N8OOR7X
ATC code	A10BK05
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H303-H320
Precautionary statements	P312-P264-P305+P351+P338-P337+P313

Ipragliflozin price More Price(87)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	I1284	Ipragliflozin	761423-87-4	200MG	$71	2026-04-30	Buy
TCI Chemical	I1284	Ipragliflozin	761423-87-4	1G	$246	2026-04-30	Buy
Cayman Chemical	22287	Ipragliflozin ≥98%	761423-87-4	10mg	$36	2026-04-30	Buy
Cayman Chemical	22287	Ipragliflozin ≥98%	761423-87-4	50mg	$153	2026-04-30	Buy
Cayman Chemical	22287	Ipragliflozin ≥98%	761423-87-4	100mg	$219	2026-04-30	Buy

Product number	Packaging	Price	Buy
I1284	200MG	$71	Buy
I1284	1G	$246	Buy
22287	10mg	$36	Buy
22287	50mg	$153	Buy
22287	100mg	$219	Buy

Ipragliflozin Chemical Properties,Uses,Production

Description

Ipragliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC₅₀ = 7.4 nM in CHO cells expressing the human cotransporter). It is selective for SGLT2 over SGLT1, SGLT3, SGLT4, SGLT5, and SGLT6 (IC₅₀s = 1.9, 30.4, 15.9, 0.46, and 10.4 μM, respectively). Ipragliflozin (0.1-3 mg/kg) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in a mouse model of diabetes induced by high-fat diet, streptozotocin (STZ; ), and nicotinamide . It decreases plasma and hepatic IL-6, TNF-α, chemokine (C-C motif) ligand 2 (CCL2), and C-reactive protein (CRP) levels in the same model when administered at a dose of 3 mg/kg per day for 28 days.

History

Ipragliflozin L-proline was approved in Japan in January 2014 for the treatment of type 2 diabetes. The drug was discovered by Astellas Pharma and co-developed and marketed with Kotobuki Pharmaceutical and Merck Sharp Dohme as Suglat. Similar to empagliflozin (XIII), ipragliflozin L-proline is a sodium-glucose 1956 A. C. Flick et al. / Bioorg. Med. Chem. 24 (2016) 1937–1980 co-transporter-2 inhibitor which prevents glucose reabsorption by excreting excess glucose in the urine. Ipragliflozin exhibits remarkable selectivity over SLGT-1 (>250x).

Uses

Ipragliflozin is a potent and selective inhibitor of sodium-glucose cotransporter-2 (SGLT2) and can serve as a potential agent for the treatment of type 1 and type 2 diabetes.

Definition

ChEBI: Ipragliflozin is a glycoside.

Trade name

Suglat

Synthesis

Commercial 5-bromo-2-fluorobenzaldehyde (123) was subjected to nucleophilic attack upon subjection to lithiated benzo[b]thiophene (124) to afford the dibenzylic alcohol 125 in 85% yield. This alcohol was then halogenated by means of thionyl chloride in acetonitrile to give 126, which was followed by treatment with sodium borohydride to give rise to 2-(5-bromo-2-fluorophenyl)- 1-benzothiophene (127), which was isolated by crystallization from 2-propanol and methanol in 81% yield across the two steps. Bromide 127 then underwent lithium¨Chalogen exchange prior to exposure to 2,3,4,6-tetrakis-O-(trimethylsilyl)- D-glucono-1,5-lactone (128) in toluene. Without workup, the resulting mixture was treated with a solution of methanol and HCl at 0 C to give a globally desilylated a-glucopyranoside intermediate. Subjection to acetic anhydride and 4-dimethylaminopyridine furnished tetra-O-acetyl ipragliflozin (129) in 75% yield for the 3 steps. Polyacetate 129 was then saponified using aqueous sodium hydroxide and the product was crystallized from methanol and water and subsequently treated with D-proline in ethanol to furnish the desired product ipragliflozin D-proline (XVI) in 68% yield.

Synthesis_761423-87-4

Mode of action

Ipragliflozin is a selective SGLT2 (sodium-glucose co-transporter 2) inhibitor discovered through research collaboration with Kotobuki Pharmaceutical Co., Ltd. SGLTs are membrane proteins that exist on the cell surface and transfer glucose into cells. SGLT2 is a subtype of the sodium-glucose co-transporters and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys. Ipragliflozin reduces blood glucose levels by inhibiting the reuptake of glucose.

References

[1] Patent: EP2105442, 2009, A1. Location in patent: Page/Page column 13
[2] Patent: CN108276396, 2018, A. Location in patent: Paragraph 0041; 0052; 0053; 0068; 0083
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3263 - 3279
[4] Patent: EP2009010, 2008, A1. Location in patent: Page/Page column 6-7

Ipragliflozin Preparation Products And Raw materials

Raw materials

D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-, 2,3,4,6-tetraacetate, (1S)- (1S)-1,5-anhydro-1-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-2,3,4,6-tetra-O-benzyl-D-glucitol Pentamethylbenzene Methanol Boron trichloride

Heptane Dichloromethane

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Preparation Products

Ipragliflozin Suppliers

Global( 241)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Cangzhou Kangrui Pharma Tech Co. Ltd.,	+86-18632776803 +86-13833998158	cangzhoukangrui@126.com	China	773	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Shanghai Longyu Biotechnology Co., Ltd.		info@longyupharma.com	China	2430	58

Supplier	Advantage
Cangzhou Kangrui Pharma Tech Co. Ltd.,	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58

View Lastest Price from Ipragliflozin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	(1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl]-D-glucitol 761423-87-4	$166.00	5g	99%	100kg	Baoji Guokang Healthchem Co., Ltd.
2026-07-14	Ipragliflozin 761423-87-4	$52.00-137.00		99.38%	10g	TargetMol Chemicals Inc.
2025-09-22	Ipragliflozin 761423-87-4		50g	99%	15kg	Cangzhou Kangrui Pharma Tech Co. Ltd.,

(1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl]-D-glucitol
761423-87-4
$166.00
99%
Baoji Guokang Healthchem Co., Ltd.

Ipragliflozin
761423-87-4
$52.00-137.00
99.38%
TargetMol Chemicals Inc.

Ipragliflozin
761423-87-4
99%
Cangzhou Kangrui Pharma Tech Co. Ltd.,

Ipragliflozin Spectrum

Ipragliflozin(761423-87-4)¹HNMR

761423-87-4(Ipragliflozin)Related Search:

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5-bromo-2-chloro-4’-ethoxydiphenylmethane (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Canagliflozin heMihydrate 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

PF-04971729 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Dapagliflozin Empagliflozin

D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Tofogliflozin LX-4211

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Ipragliflozin, >=98% IpragliflozinL-Proline Ipragliflozin (ASP1941) Ipragliflozin impuity (1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)methyl]-4-fluorophenyl]-D-glucitol Ipragliflozin ASP-1941/D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]-, (1S)- Ipragliflozin, (1S)-1,5-Anhydro-1-C-[3-[(1-benzothiophen-2-yl)Methyl]-4-fluorophenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol Ipragliflozin （Suglat） IpragliflozinL-Proline int Ipragliflozin-002 Ipragliflozin Impurity CS-1580 D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-, (1S)- Suglat Iprag iflozin Igliazine Ipragliflozin, 10 mM in DMSO Iglienet free base Yigelejing Ipraglifozin 761423-87-4 C21H21FO5S C21H21FOS Inhibitors