N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol
- CAS No.
- 106984-09-2
- Chemical Name:
- N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol
- Synonyms
- BocNH-PEG4-OH;(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-carbamic Acid tert-Butyl Ester;Boc-NH-PEG4;2-[2-(2-(2-Boc-aminoethoxy)ethoxy)ethoxy]ethanol;NHBoc-PEG4-OH;PROTAC Linker 12;N-Boc-PEG4-alcohol;BocNH-PEG4-alcohol;t-boc-N-amido-dPEG??-OH;t-Boc-Amido-PEG4-Alcohol
- CBNumber:
- CB8285205
- Molecular Formula:
- C13H27NO6
- Molecular Weight:
- 293.36
- MDL Number:
- MFCD07779195
- MOL File:
- 106984-09-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 414.0±35.0 °C(Predicted) |
|---|---|
| Density | 1.078±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.23±0.46(Predicted) |
| form | Oil |
| color | Clear Light Yellow |
| InChI | InChI=1S/C13H27NO6/c1-13(2,3)20-12(16)14-4-6-17-8-10-19-11-9-18-7-5-15/h15H,4-11H2,1-3H3,(H,14,16) |
| InChIKey | XKKDQIAPTPFIGW-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCCOCCOCCOCCO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2924190090 |
N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 516856 | Boc-NH-PEG4-Hydroxyl (1-Boc-amino-3,6,9-trioxaundecanyl-11-ol) ≥95% | 106984-09-2 | 5g | $814 | 2026-06-03 | Buy |
| Usbiological | 262903 | 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol ~97%(GC) | 106984-09-2 | 50mg | $350 | 2026-06-03 | Buy |
| Usbiological | 262903 | 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol ~97%(GC) | 106984-09-2 | 100mg | $483 | 2026-06-03 | Buy |
| Usbiological | 262903 | 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol ~97%(GC) | 106984-09-2 | 250mg | $715 | 2026-06-03 | Buy |
| Usbiological | 262903 | 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol ~97%(GC) | 106984-09-2 | 500mg | $991 | 2026-06-03 | Buy |
N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol Chemical Properties,Uses,Production
Uses
1-Boc-amino-3,6,9-trioxaundecanyl-11-ol is a compound useful in organic synthesis.
Description
N-Boc-PEG4-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
Yellow Oil
Uses
Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Synthesis
24424-99-5
86770-74-3
106984-09-2
Example 5: Synthesis of tert-butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl) carbamate Step 1: Synthesis of S9 In a round bottom flask, 1-amino-3,6,9-trioxa-11-undecanol (2.9 g, 15 mmol) was dissolved in 10 mL of ethanol. Another di-tert-butyl dicarbonate (3.6 g, 16.5 mmol) was dissolved in 10 mL of ethanol and added to the above solution slowly and dropwise over 10 minutes. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the residue was purified by column chromatography using dichloromethane/methanol system to give S9 as a colorless oil (3.69 g, 80% yield). 1H NMR (400 MHz, CDCl3) δ (ppm): 5.49 (s, 1H), 3.46-3.25 (m, 14H), 3.02 (s, 2H), 1.18 (s, 9H); ESI-MS calculated value C13H27NNaO4 [M + Na]+ = 316.17, measured value: 316.18.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Shanghai Yanfen Biochemical Technology Co.,LTD | 13611955358 15002190549 | yanfen2023@126.com | China | 2573 | 58 |
| Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd | 50929289 18616309303 | sales@ypptech.com.cn | China | 384 | 58 |
| Wanxin Biotechnology (Jiaxing) Co., LTD | 0573-83568680 18057391398 | 3956524501@qq.com | China | 1441 | 58 |
| Shandong Mingde Biotechnology Co., Ltd. | 18560864701 | 2037956468@qq.com | China | 831 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alabiochem Tech.Co., Ltd. | 512-58900862 400-0707518 | sales@alabiochem.com | China | 988 | 59 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | N-Boc-PEG4-alcohol
106984-09-2
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-07-24 | Boc-NH-PEG4-OH
106984-09-2
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-04-21 | Boc-NH-PEG4
106984-09-2
|
10g | TargetMol Chemicals Inc. |
-
- N-Boc-PEG4-alcohol
106984-09-2
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- Boc-NH-PEG4-OH
106984-09-2
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Boc-NH-PEG4
106984-09-2
- $0.00
- TargetMol Chemicals Inc.
106984-09-2(N-Boc-aminoehtoxy-ethoxy-ethoxy-ethanol)Related Search:
1of4
