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SAR-407899

SAR-407899 Structure
SAR-407899 structure
CAS No.
923262-96-8
Chemical Name:
SAR-407899
Synonyms
CS-2364;SAR407899;SAR 407899;SAR-407899;SAR407899 HCl;SAR 407899;SAR407899;SAR407899 (hydrochloride);SAR407899 hydrochloride ，E2385;SAR-407899 （SAR407899，SAR 407899）;SAR407899 hydrochloride, 10 mM in DMSO
CBNumber:
CB02666958
Molecular Formula:
C14H17ClN2O2
Molecular Weight:
280.74998
MDL Number:
MFCD20485429
MOL File:
923262-96-8.mol
MSDS File:
SDS
Last updated:2025-10-26 21:25:35
Product description Number Pack Size Price
SAR407899hydrochloride >98.0% CS-3569 5mg $60
SAR407899hydrochloride B4909 2mg $95
SAR407899hydrochloride >98.0% CS-3569 10mg $100
SAR407899hydrochloride B4909 5mg $156
SAR407899hydrochloride B4909 10mg $268
More product size
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SAR-407899 Properties

storage temp. Store at -20°C
solubility H2O : 50 mg/mL (178.09 mM; Need ultrasonic)DMSO : 25 mg/mL (89.05 mM; Need ultrasonic)
form Powder
color Light yellow to khaki
FDA UNII AD9C9XVB9T

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

SAR-407899 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-3569 SAR407899hydrochloride >98.0% 923262-96-8 5mg $60 2021-12-16 Buy
ApexBio Technology B4909 SAR407899hydrochloride 923262-96-8 2mg $95 2021-12-16 Buy
ChemScene CS-3569 SAR407899hydrochloride >98.0% 923262-96-8 10mg $100 2021-12-16 Buy
ApexBio Technology B4909 SAR407899hydrochloride 923262-96-8 5mg $156 2021-12-16 Buy
ApexBio Technology B4909 SAR407899hydrochloride 923262-96-8 10mg $268 2021-12-16 Buy
Product number Packaging Price Buy
CS-3569 5mg $60 Buy
B4909 2mg $95 Buy
CS-3569 10mg $100 Buy
B4909 5mg $156 Buy
B4909 10mg $268 Buy

SAR-407899 Chemical Properties,Uses,Production

Uses

SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

in vivo

SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPTT696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits[2].

IC 50

ROCK-2: 102 nM (IC50); ROCK-1: 276 nM (IC50)

References

[1] L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7. DOI:10.1016/j.trim.2018.06.002

SAR-407899 synthesis

1417697-15-4
923262-96-8
Synthesis of SAR-407899 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

SAR-407899 Preparation Products And Raw materials

Raw materials

4-Fluoro-2-methylbenzonitrile N-BOC-4-Hydroxypiperidine

Preparation Products

SAR-407899 Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29799 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Shenzhen Shengda Pharma Limited 		58
InvivoChem 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61

View Lastest Price from SAR-407899 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAR407899 hydrochloride pictures 2025-10-26 SAR407899 hydrochloride
923262-96-8
 US $30.00-93.00 / mg 98.01% 10g TargetMol Chemicals Inc.
SAR-407899 pictures 2020-03-16 SAR-407899
923262-96-8
 US $1.00 / KG 1KG 97%-99.9% 100KG Career Henan Chemical Co
  • SAR-407899 pictures
  • SAR-407899
    923262-96-8
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co
SAR 407899 SAR407899 SAR-407899 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride 6-(piperidin-4-yloxy)isoquinolin-1(2h)-one hcl SAR407899 (hydrochloride) SAR407899 HCl 6-(4-Piperidinyloxy)-1(2H)-isoquinolinone hydrochloride 6-(4-Piperidinyloxy)-1(2H)-isoquinolinone hydrochloride (1:1) CS-2364 SAR-407899 （SAR407899，SAR 407899） SAR 407899;SAR407899 SAR-407899,Rho-associated protein kinase,ROK,Rho-associated kinase,SAR 407899,SAR-407899 hydrochloride,Rho-kinase,Inhibitor,inhibit,SAR407899 hydrochloride,ROCK,SAR407899 SAR407899 hydrochloride, 10 mM in DMSO SAR407899 hydrochloride ，E2385 923262-96-8 API