Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Sar-407899

Sar-407899

Sar-407899 Structure
Sar-407899 structure
CAS No.
923262-96-8
Chemical Name:
Sar-407899
Synonyms
SAR407899;SAR 407899;CS-2364;Sar-407899;SAR407899 HCl;SAR 407899;SAR407899;SAR407899 (hydrochloride);SAR407899 hydrochloride ，E2385;SAR-407899 （SAR407899，SAR 407899）;SAR407899 hydrochloride, 10 mM in DMSO
CBNumber:
CB02666958
Molecular Formula:
C14H17ClN2O2
Molecular Weight:
280.74998
MDL Number:
MFCD20485429
MOL File:
923262-96-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:01
Request For Quotation

Sar-407899 Properties

storage temp. Store at -20°C
solubility H2O : 50 mg/mL (178.09 mM; Need ultrasonic)DMSO : 25 mg/mL (89.05 mM; Need ultrasonic)
form Powder
color Light yellow to khaki
FDA UNII AD9C9XVB9T

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Sar-407899 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-3569 SAR407899 (hydrochloride) 99.14% 923262-96-8 5mg $65 2026-06-04 Buy
ChemScene CS-3569 SAR407899 (hydrochloride) 99.14% 923262-96-8 10mg $97 2026-06-04 Buy
ChemScene CS-3569 SAR407899 (hydrochloride) 99.14% 923262-96-8 50mg $292 2026-06-04 Buy
ChemScene CS-3569 SAR407899 (hydrochloride) 99.14% 923262-96-8 100mg $466 2026-06-04 Buy
Matrix Scientific 120784 6-(Piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride 923262-96-8 2.00g $1565 2026-05-18 Buy
Product number Packaging Price Buy
CS-3569 5mg $65 Buy
CS-3569 10mg $97 Buy
CS-3569 50mg $292 Buy
CS-3569 100mg $466 Buy
120784 2.00g $1565 Buy

Sar-407899 Chemical Properties, Uses, Production

Uses

SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

in vivo

SAR407899 (3 mg/kg, i.v.) inhibits ROCK-mediated phosphorylation of MYPTT696 in thoracic aorta of spontaneously hypertensive rats (SHRs). SAR407899 (0.01-0.30 mg/kg, i.v.) efficiently reduces pressor responses to vasoconstrictor agents in rats. SAR407899 (1, 3, 10, and 30 mg/kg, p.o.) dose dependently lowers blood pressure in hypertensive SHRs[1]. SAR407899 (1-3 mg/kg, i.v. or 3, 10 mg/kg, p.o.) increases the length of the penis in healthy rabbits. SAR407899 (3-10 mg/kg, p.o.) also dose-dependently increases penile length in diabetic rabbits[2].

IC 50

ROCK-2: 102 nM (IC50); ROCK-1: 276 nM (IC50)

References

[1] Lhn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83. DOI:10.1161/HYPERTENSIONAHA.109.134353
[2] Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59. DOI:10.1186/1479-5876-10-59
[3] Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7. DOI:10.1016/j.trim.2018.06.002

Sar-407899 synthesis

1417697-15-4
923262-96-8
Synthesis of Sar-407899 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

Sar-407899 Preparation Products And Raw materials

Raw materials

4-Fluoro-2-methylbenzonitrile N-BOC-4-Hydroxypiperidine

Preparation Products

Sar-407899 Suppliers

Global Suppliers ( 76)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai DongYang Biotechnology Co., Ltd. 18657622632 chemsharker@126.com China 371 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
SPIRO PHARMA eric_feng1954@126.com China 9239 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
CEG Chemical Science&Technology Co., Ltd. 58
Bide Pharmatech Ltd. 60
AdooQ Bioscience CHINA 60
LETOPHARM LIMITED 58
Shanghai DongYang Biotechnology Co., Ltd. 55
Shanghaizehan biopharma technology co., Ltd. 55
SPIRO PHARMA 55

View Latest Price from Sar-407899 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SAR407899 hydrochloride pictures 2026-07-15 SAR407899 hydrochloride
923262-96-8
 $30.00-93.00 99.15% 10g TargetMol Chemicals Inc.
SAR-407899 pictures 2020-03-16 SAR-407899
923262-96-8
 $1.00 1KG 97%-99.9% 100KG Career Henan Chemical Co
  • SAR-407899 pictures
  • SAR-407899
    923262-96-8
  • $1.00
  • 97%-99.9%
  • Career Henan Chemical Co

Sar-407899 Spectrum

SAR-407899(923262-96-8)1HNMR

923262-96-8 (Sar-407899) Related Search:

2-(2-Methoxyethyl)-5-(1-methylpropoxy)-1(2H)-isoquinolinone 2-[(3-Chlorophenyl)methyl]-6-(1-methylethoxy)-1(2H)-isoquinolinone NA Sar-407899 SAR407899
1(2H)-Isoquinolinone, 7-ethoxy-

1of2

6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride 6-(piperidin-4-yloxy)isoquinolin-1(2h)-one hcl SAR407899 (hydrochloride) SAR407899 HCl 6-(4-Piperidinyloxy)-1(2H)-isoquinolinone hydrochloride 6-(4-Piperidinyloxy)-1(2H)-isoquinolinone hydrochloride (1:1) CS-2364 SAR-407899 （SAR407899，SAR 407899） SAR 407899;SAR407899 SAR-407899,Rho-associated protein kinase,ROK,Rho-associated kinase,SAR 407899,SAR-407899 hydrochloride,Rho-kinase,Inhibitor,inhibit,SAR407899 hydrochloride,ROCK,SAR407899 SAR407899 hydrochloride, 10 mM in DMSO SAR407899 hydrochloride ，E2385 SAR 407899 SAR407899 Sar-407899 923262-96-8 API