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4-Fluoro-2-methylbenzonitrile

4-Fluoro-2-methylbenzonitrile structure

CAS No.: 147754-12-9

Chemical Name:: 4-Fluoro-2-methylbenzonitrile

Synonyms: 4-Fluoro-2-methylben;Alogliptin Impurity 84;Trelagliptin Impurity 58;Methyl-4-fluorobenzonitrile;2-METHYL-4-FLUOROBENZONITRILE;4-FLUORO-2-METHYLBENZONITRILE;2-Methy-4-Fluoro benzonitrile;Benzonitrile, 4-fluoro-2-methyl-;4-Fluoro-2-methylbenzonitrile >4-Fluoro-2-methylbenzonitrile,97%

CBNumber:: CB4167413

Molecular Formula:: C8H6FN

Molecular Weight:: 135.14

MDL Number:: MFCD03095106

MOL File:: 147754-12-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:45:09

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4-Fluoro-2-methylbenzonitrile Properties

Melting point	70-74 °C (lit.)
Boiling point	214.6±20.0 °C(Predicted)
Density	1.11±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
color	White to Almost white
InChI	InChI=1S/C8H6FN/c1-6-4-8(9)3-2-7(6)5-10/h2-4H,1H3
InChIKey	BJBXUIUJKPOZLV-UHFFFAOYSA-N
SMILES	C(#N)C1=CC=C(F)C=C1C
CAS DataBase Reference	147754-12-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN3439

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29269090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4-Fluoro-2-methylbenzonitrile price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	594660	4-Fluoro-2-methylbenzonitrile 97%	147754-12-9	5g	$156	2023-06-20	Buy
TCI Chemical	F0962	4-Fluoro-2-methylbenzonitrile >99.0%(GC)	147754-12-9	1g	$31	2026-04-30	Buy
TCI Chemical	F0962	4-Fluoro-2-methylbenzonitrile >99.0%(GC)	147754-12-9	5g	$122	2026-04-30	Buy
Apolloscientific	PC1841	4-Fluoro-2-methylbenzonitrile ≥95%	147754-12-9	5g	$21	2026-06-04	Buy
Apolloscientific	PC1841	4-Fluoro-2-methylbenzonitrile ≥95%	147754-12-9	25g	$24	2026-06-04	Buy

Product number	Packaging	Price	Buy
594660	5g	$156	Buy
F0962	1g	$31	Buy
F0962	5g	$122	Buy
PC1841	5g	$21	Buy
PC1841	25g	$24	Buy

4-Fluoro-2-methylbenzonitrile Chemical Properties, Uses, Production

Chemical Properties

White to light yellow crystalline powder

Uses

As organic intermediate, pharmaceutical intermediate. In chemical synthesis.

Synthesis

80141-91-9

147754-12-9

The general procedure for the synthesis of 4-fluoro-2-methylbenzonitrile from 4-fluoro-2-methylbenzenemethanol was as follows: in a 25 mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-fluoro-2-methylbenzenemethanol (1 mmol) and an aqueous ammonia solution (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature under argon protection for 24 h. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. Subsequently, the organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the target product 4-fluoro-2-methylbenzonitrile.

References

[1] Organic Letters, 2013, vol. 15, # 8, p. 1850 - 1853
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466

4-Fluoro-2-methylbenzonitrile Preparation Products And Raw materials

Raw materials

4-Fluoro-2-methylbenzyl alcohol 2-Bromo-5-fluorotoluene Copper(I) Cyanide Copper(I) chloride Ammonia

4-Hydroxy-TEMPO Triethylenediamine Acetonitrile

1of2

Preparation Products

4-Fluoro-2-methylbenzoic acid Sar-407899

4-Fluoro-2-methylbenzonitrile Suppliers

Global Suppliers ( 362)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Beijing Huize Zhongsen Pharmaceutical Technology Co., Ltd.	18519331287 18519331287	1751713684@qq.com	China	268	58
Jilin Lianben Technology Development Co., Ltd			China	46	58
China Shenyang Tyschem CO. ,LTD	+86-024-83607930 18640359690	sales@honghuchem.com	China	256	58
Shijiazhuang Surui Chemical Co., LTD	15833970389 15833970389	sjzkhhg@126.com	China	36	58
Nanjing Intermate Technology Co., Ltd	18501091076	57715449@qq.com	China	102	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65

Supplier	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Beijing Huize Zhongsen Pharmaceutical Technology Co., Ltd.	58
Jilin Lianben Technology Development Co., Ltd	58
China Shenyang Tyschem CO. ,LTD	58
Shijiazhuang Surui Chemical Co., LTD	58
Nanjing Intermate Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
ChemFuture PharmaTech (Jiangsu) Ltd	65

View Latest Price from 4-Fluoro-2-methylbenzonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4-Fluoro-2-methylbenzonitrile 147754-12-9	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2024-04-25	4-Fluoro-2-methylbenzonitrile 147754-12-9	$30.00-100.00	1kg	99.93%	1000kg per week	Ouhuang Engineering Materials (Hubei) Co., Ltd
2022-02-09	4-Fluoro-2-methylbenzonitrile 147754-12-9		1KG	97.5%	100 tons	Honest Joy Holdings Limited

4-Fluoro-2-methylbenzonitrile
147754-12-9
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Fluoro-2-methylbenzonitrile
147754-12-9
$30.00-100.00
99.93%
Ouhuang Engineering Materials (Hubei) Co., Ltd

4-Fluoro-2-methylbenzonitrile
147754-12-9
$0.00
97.5%
Honest Joy Holdings Limited

4-Fluoro-2-methylbenzonitrile Spectrum

4-Fluoro-2-methylbenzonitrile(147754-12-9)¹HNMR

147754-12-9 (4-Fluoro-2-methylbenzonitrile) Related Search:

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2-Methy-4-Fluoro benzonitrile Benzonitrile, 4-fluoro-2-methyl- (9CI) 4-Fluoro-2-methylbenzonitrile,97% 4-Fluoro-2-methylben 4-Fluoro-o-tolunitrile, 2-Cyano-5-fluorotoluene Benzonitrile, 4-fluoro-2-methyl- Methyl-4-fluorobenzonitrile 4-FLUORO-2-METHYLBENZONITRILE 2-METHYL-4-FLUOROBENZONITRILE Trelagliptin Impurity 58 4-Fluoro-2-methylbenzonitrile > Alogliptin Impurity 84 4-Fluoro-2-methylbenzonitrile, 98% 4-Fluoro-2-methylbenzonitrile / 2-Methyl-4-fluorobenzonitrile 147754-12-9 144754-12-9 FC6H3CH3CN Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks C8 to C9 Building Blocks NITRILE Miscellaneous Fluorine Compounds Nitriles C8 to C9 Cyanides/Nitriles Nitrogen Compounds