4-Fluoro-2-methoxybenzonitrile
- CAS No.
- 191014-55-8
- Chemical Name:
- 4-Fluoro-2-methoxybenzonitrile
- Synonyms
- BUTTPARK 80\07-22;4-Fluoro-o-anisonitrile;4-Fluoro-2-methoxybenzonitril;4-FLUORO-2-METHOXYBENZONITRILE;Benzonitrile, 4-fluoro-2-methoxy-;Benzonitrile, 4-fluoro-2-methoxy- (9CI);4-Fluoro-o-anisonitrile, 2-Cyano-5-fluoroanisole
- CBNumber:
- CB0298137
- Molecular Formula:
- C8H6FNO
- Molecular Weight:
- 151.14
- MDL Number:
- MFCD04116335
- MOL File:
- 191014-55-8.mol
| Melting point | 75 °C |
|---|---|
| Boiling point | 239.2±20.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 191014-55-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H331 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 23-36/37/39 | |||||||||
| RIDADR | 3276 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2926907090 | |||||||||
| NFPA 704 |
|
4-Fluoro-2-methoxybenzonitrile price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F599358 | 4-Fluoro-2-methoxybenzonitrile | 191014-55-8 | 500mg | $75 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3637-3-X1 | 4-Fluoro-2-methoxybenzonitrile | 191014-55-8 | 25g | $232 | 2021-12-16 | Buy |
| AK Scientific | X2776 | 4-Fluoro-2-methoxybenzonitrile | 191014-55-8 | 25g | $237 | 2021-12-16 | Buy |
| Matrix Scientific | 131684 | 4-Fluoro-2-methoxybenzonitrile 97% | 191014-55-8 | 25g | $468 | 2021-12-16 | Buy |
| AK Scientific | X2776 | 4-Fluoro-2-methoxybenzonitrile | 191014-55-8 | 100g | $571 | 2021-12-16 | Buy |
4-Fluoro-2-methoxybenzonitrile Chemical Properties,Uses,Production
Chemical Properties
off-white crytalline
Synthesis
450-88-4
544-92-3
191014-55-8
General procedure for the synthesis of 2-methoxy-4-fluorobenzonitrile from 2-bromo-5-fluoroanisole and cuprous cyanide: to a solution of N-methylpyrrolidone (100 mL, Sure Seal; Aldrich) containing 1-bromo-4-fluoro-2-methoxybenzene (9.0 g) was added cuprous cyanide (6.6 g, 73.7 mmol, 1.8 equiv. Aldrich). The reaction mixture was stirred at 180 °C for 5.5 h in an anhydrous nitrogen atmosphere. After completion of the reaction, it was cooled to room temperature, a 14% aqueous ammonia solution (330 mL) was added, and stirring was continued at room temperature for 45 min. The reaction mixture was extracted with ether (100 mL x 3), and the organic phases were combined, washed sequentially with dilute ammonia, dilute hydrochloric acid and brine, and then dried with anhydrous magnesium sulfate, and concentrated to give 2-methoxy-4-fluorobenzonitrile (5.2 g, 85% yield in two steps). The product was a white solid with the following 1H NMR (CDCl3,500MHz) data: δ 3.91 (3H, s, OMe), 6.69 (1H, dd, J = 2.3Hz, J = 10.5Hz, Ar-H), 6.72 (1H, dt, J = 2.5Hz, J = 8.0Hz, Ar-H), 7.55 (1H, dd, J = 6.5 Hz, J = 8.5 Hz, Ar-H); 13C NMR (CDCl3,125.8 Hz) data as follows: δ 56.49, 98.16, 100.06, 100.27, 108.31, 108.50, 115.83, 135.37, 135.46, 163.25, 163.34, 165.47, 167.50. 167.50. analytical samples were obtained by ether milling. Calculated values for elemental analysis (C8H6FNO): C, 63.57; H, 4.00; N, 9.26; measured values: C, 63.36; H, 3.91; N, 9.16.
References
[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 67
[2] Patent: EP1510516, 2005, A1. Location in patent: Page/Page column 88
[3] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 32-33
[4] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 26
[5] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 152
4-Fluoro-2-methoxybenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12338 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 4-Fluoro-2-methoxybenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-08-15 | 4-Fluoro-2-methoxybenzonitrile
191014-55-8
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-07-25 | 4-Fluoro-2-methoxybenzonitrile
191014-55-8
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-24 | 4-Fluoro-2-methoxybenzonitrile
191014-55-8
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Fluoro-2-methoxybenzonitrile
191014-55-8
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 4-Fluoro-2-methoxybenzonitrile
191014-55-8
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Fluoro-2-methoxybenzonitrile
191014-55-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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