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2-Fluoro-5-methoxybenzonitrile

2-Fluoro-5-methoxybenzonitrile Structure
2-Fluoro-5-methoxybenzonitrile structure
CAS No.
127667-01-0
Chemical Name:
2-Fluoro-5-methoxybenzonitrile
Synonyms
BUTTPARK 80\01-21;3-Cyano-4-fluoroanisole;6-Fluoro-m-anisonitrile;Fluoromethoxybenzonitrile;Fluoromethoxybenzonitrile2;2-fluoro-methoxybenzonitrile;2-Fluoro-5-methoxybenzonitrile;2-Fluoro-5-methyloxybenzonitrile;2-Fluoro-5-methoxybenzonitrile98%;Benzonitrile, 2-fluoro-5-methoxy-
CBNumber:
CB4293044
Molecular Formula:
C8H6FNO
Molecular Weight:
151.14
MDL Number:
MFCD00142921
MOL File:
127667-01-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:44
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2-Fluoro-5-methoxybenzonitrile Properties

Melting point 77-80°C
Boiling point 232.7±25.0 °C(Predicted)
Density 1.18±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
color White to Almost white
InChI 1S/C8H6FNO/c1-11-7-2-3-8(9)6(4-7)5-10/h2-4H,1H3
InChIKey VBZLRHYLNXWZIU-UHFFFAOYSA-N
SMILES Fc1c(cc(cc1)OC)C#N
CAS DataBase Reference 127667-01-0(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H335
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
target organs Respiratory system
Hazard Codes  T
Risk Statements  20/21/22-36/37/38-36/38
Safety Statements  26-36/37/39-45-36/37
RIDADR  3439
WGK Germany  3
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29269090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
3 0

2-Fluoro-5-methoxybenzonitrile price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich MNO000003 2-Fluoro-5-methoxybenzonitrile Aldrich 127667-01-0 1g $45.5 2026-04-30 Buy
TCI Chemical F0642 2-Fluoro-5-methoxybenzonitrile >98.0%(GC) 127667-01-0 1g $28 2026-04-30 Buy
TCI Chemical F0642 2-Fluoro-5-methoxybenzonitrile >98.0%(GC) 127667-01-0 5g $109 2026-04-30 Buy
Biosynth FF64148 2-Fluoro-5-methoxybenzonitrile 127667-01-0 10g $150 2026-06-04 Buy
Biosynth FF64148 2-Fluoro-5-methoxybenzonitrile 127667-01-0 2g $150 2026-06-04 Buy
Product number Packaging Price Buy
MNO000003 1g $45.5 Buy
F0642 1g $28 Buy
F0642 5g $109 Buy
FF64148 10g $150 Buy
FF64148 2g $150 Buy

2-Fluoro-5-methoxybenzonitrile Chemical Properties, Uses, Production

Synthesis

Benzaldehyde, 2-fluoro-5-methoxy-, oxime

796120-91-7

2-FLUORO-5-METHOXYBENZONITRILE

127667-01-0

The general procedure for the synthesis of 2-fluoro-5-methoxybenzonitrile from the compound (CAS: 796120-91-7) was as follows: 15 g of 2-fluoro-5-methoxybenzaldehyde oxime was dissolved in 150 mL of tetrahydrofuran, followed by the addition of 40 g of trifluoroacetic anhydride. 20 mL of triethylamine was slowly added under stirring. Upon completion of the reaction, the reaction mixture was concentrated to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate. The organic phase was separated, dried with anhydrous sodium sulfate, and then concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography to give 11 g of 2-fluoro-5-methoxybenzonitrile.

References

[1] Patent: CN107778264, 2018, A. Location in patent: Paragraph 0029; 0030
[2] Patent: CN107698535, 2018, A. Location in patent: Paragraph 0029; 0030
[3] Patent: CN108129415, 2018, A. Location in patent: Paragraph 0029-0030

2-Fluoro-5-methoxybenzonitrile synthesis

796120-91-7
127667-01-0
Synthesis of 2-Fluoro-5-methoxybenzonitrile from Benzaldehyde, 2-fluoro-5-methoxy-, oxime

2-Fluoro-5-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Benzaldehyde, 2-fluoro-5-methoxy-, oxime 3-Chloro-4-fluoroanisole 2-Fluoro-5-methoxybenzaldehyde 5-Bromo-2-fluorobenzonitrile Methanol
4-Fluoroanisole Triethylamine Copper(I) Cyanide Trifluoroacetic anhydride Tetrahydrofuran

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Preparation Products

2-Fluoro-5-hydroxybenzenecarbonitrile 2-Fluoro-5-hydroxybenzoic acid

2-Fluoro-5-methoxybenzonitrile Suppliers

Global Suppliers ( 210)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Ark Pharm, Inc. 56
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 2-Fluoro-5-methoxybenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-FLUORO-5-METHOXYBENZONITRILE pictures 2026-03-20 2-FLUORO-5-METHOXYBENZONITRILE
127667-01-0
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-FLUORO-5-METHOXYBENZONITRILE pictures 2025-04-15 2-FLUORO-5-METHOXYBENZONITRILE
127667-01-0
 $10.00 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
2-FLUORO-5-METHOXYBENZONITRILE pictures 2019-07-14 2-FLUORO-5-METHOXYBENZONITRILE
127667-01-0
 $1.00 1KG 99% 100kg Career Henan Chemical Co

2-Fluoro-5-methoxybenzonitrile Spectrum

2-FLUORO-5-METHOXYBENZONITRILE(127667-01-0)1HNMR

127667-01-0 (2-Fluoro-5-methoxybenzonitrile) Related Search:

2-Chloro-6-fluoro-3-methoxybenzonitrile 5-Fluoro-2-methoxybenzonitrile 3-Fluoro-4-methoxybenzonitrile 2-Fluoro-4-(trifluoromethyl)benzonitrile 4-Fluoro-3-methoxybenzonitrile
Anisonitrile 4-Fluoroanisole 2-Fluoro-6-methoxybenzonitrile98%,2-Fluoro-6-methoxybenzonitrile 98%,2-FLUORO-6-METHOXYBENZONITRILE 3-Methoxy-2,4-difluorobenzonitrile 2-FLUORO-4-METHOXYBENZONITRILE
3-Chloro-5-fluoro-4-methoxybenzonitrile 3-Fluoro-5-methoxybenzonitrile 2-Fluoro-5-(trifluoromethoxy)benzonitrile 4-FLUORO-2-METHOXYBENZONITRILE 4,5-Difluoro-2-methoxybenzonitrile
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BUTTPARK 80\01-21 Fluoromethoxybenzonitrile2 2-Fluoro-5-methyloxybenzonitrile 2-Fluoro-5-methoxybenzonitrile98% 6-Fluoro-m-anisonitrile 3-Cyano-4-fluoroanisole Benzonitrile, 2-fluoro-5-methoxy- 2-fluoro-methoxybenzonitrile 3-Cyano-4-fluoroanisole, 6-Fluoro-m-anisonitrile 2-Fluoro-5-methoxybenzonitrile> Fluoromethoxybenzonitrile 2-Fluoro-5-methoxybenzonitrile 127667-01-0 Fluorine series Nitrile Anisoles, Alkyloxy Compounds & Phenylacetates Fluorine Compounds Nitriles Aromatic Nitriles