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2-Amino-3-hydroxypyridine

2-Amino-3-hydroxypyridine structure

CAS No.: 16867-03-1

Chemical Name:: 2-Amino-3-hydroxypyridine

Synonyms: 2-AMINO-PYRIDIN-3-OL;2-AMINO-3-PYRIDINOL;2-amino-3-pyridi;2-AMINO-3-PYRIDOL;2-amino-3-pyridino;2-Amino-3-hydroxypyr;3-PYRIDINOL, 2-AMINO-;Fampridine Impurity 11;Dopexamine Impurity 14;2-Amino-3-pyridinol 13C

CBNumber:: CB0302223

Molecular Formula:: C5H6N2O

Molecular Weight:: 110.11

MDL Number:: MFCD00006317

MOL File:: 16867-03-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-16 07:06:08

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2-Amino-3-hydroxypyridine Properties

Melting point	168-172 °C (lit.)
Boiling point	206.4°C (rough estimate)
Density	1.2111 (rough estimate)
vapor pressure	0.007-0.28Pa at 20-50℃
refractive index	1.4800 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	5.15±0.10(Predicted)
form	Crystalline Powder
color	Grayish-beige to brownish
BRN	109868
Cosmetics Ingredients Functions	HAIR DYEING
Cosmetic Ingredient Review (CIR)	2-Amino-3-hydroxypyridine (16867-03-1)
InChI	1S/C5H6N2O/c6-5-4(8)2-1-3-7-5/h1-3,8H,(H2,6,7)
InChIKey	BMTSZVZQNMNPCT-UHFFFAOYSA-N
SMILES	Nc1ncccc1O
LogP	-0.25 at 23℃ and pH7.02-7.04
Surface tension	72.6mN/m at 1.053g/L and 20℃
CAS DataBase Reference	16867-03-1(CAS DataBase Reference)
EWG's Food Scores	1-3
FDA UNII	P8740PEW4B
NIST Chemistry Reference	2-Amino-3-hydroxypyridine(16867-03-1)
UNSPSC Code	41116107
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T,Xn

Risk Statements

36/37/38-25-40

Safety Statements

26-45-37/39-28A-36-22

RIDADR

UN2811

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29333999

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2

REACH Registrations

Active

NFPA 704

	1
3		0

2-Amino-3-hydroxypyridine price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	122513	2-Amino-3-hydroxypyridine 98%	16867-03-1	100g	$416	2023-06-20	Buy
TCI Chemical	A1089	2-Amino-3-hydroxypyridine >98.0%(HPLC)(T)	16867-03-1	25g	$168	2026-04-30	Buy
Usbiological	229721	2-Amino-3-hydroxypyridine 99+% (HPLC) ≥99%(HPLC)	16867-03-1	25g	$163	2026-06-03	Buy
Usbiological	229721	2-Amino-3-hydroxypyridine 99+% (HPLC) ≥99%(HPLC)	16867-03-1	100g	$200	2026-06-03	Buy
Usbiological	229721	2-Amino-3-hydroxypyridine 99+% (HPLC) ≥99%(HPLC)	16867-03-1	250g	$295	2026-06-03	Buy

Product number	Packaging	Price	Buy
122513	100g	$416	Buy
A1089	25g	$168	Buy
229721	25g	$163	Buy
229721	100g	$200	Buy
229721	250g	$295	Buy

2-Amino-3-hydroxypyridine Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 14, p. 203, 1977 DOI: 10.1002/jhet.5570140206

General Description

2-Amino-3-hydroxypyridine forms complexes with number of transition metals. It inhibits the corrosion of aluminium and copper in acidic solutions. It undergoes condensation with 2-hydroxy-1-naphthaldehyde and 2-hydroxybenzaldehyde to form Schiffs bases. It is useful in the preparation of clinical anti-inflammatory analgesics.

Synthesis

15128-82-2

16867-03-1

General method: 3-hydroxy-2-nitropyridine (1 eq.), hexafluoroisopropanol (HFIP, 10 eq.) and iron powder (5 eq.) were added to the reaction tube and mixed. Subsequently, 2N aqueous hydrochloric acid solution was slowly added to the reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes and then neutralized with saturated aqueous sodium bicarbonate (NaHCO3) solution. The organic layer was extracted three times with aqueous sodium bicarbonate and combined. The organic layers were subsequently washed with brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford the target product 2-amino-3-hydroxypyridine.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 37, p. 3646 - 3649
[2] Journal of the Chemical Society, <1957> 4625,
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 350,352
[4] Biochemical Journal, 1950, vol. 46, p. 506
[5] Patent: US1889303, 1930,

2-Amino-3-hydroxypyridine synthesis

Synthesis of 2-Amino-3-hydroxypyridine from 3-Nitro-2-pyridinol

2-Amino-3-hydroxypyridine Preparation Products And Raw materials

Raw materials

3-Hydroxypicolinic acid 2-Amino-3-benzyloxypyridine 3-Hydroxypicolinamide 2-Furamide 2-Amino-3-ethoxypyridine

2-Iodo-3-hydroxypyridine 3-Hydroxy-2-nitropyridine Hexamethylphosphoramide 3-Nitro-2-pyridinol 3-Hydroxypyridine

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Preparation Products

2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Paliperidone Impurity 4 tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one

N,N-DiMethyl-4-(oxazolo[4,5-b]pyridin-2-yl)aniline 3-[(3,4-Dichlorobenzyl)oxy]pyridin-2-amine

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2-Amino-3-hydroxypyridine Suppliers

Global( 738)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Yancheng Yuntao Chemical Co., Ltd.	13512592619	2838893166@qq.com	China	103	58
Zhejiang Sunrise Pharmaceutical Co. LTD	19858706631 19858706631	lvyangsheng@sfcc.com	China	20	58
Dongyang Baihang Chemical Co., Ltd.	0579-86886233 18006543966	355093164@qq.com	China	113	58
Hengshui Rayson Chemical Technology Co. , Ltd.	0318-8888981 13785822979	1532555757@qq.com	China	18	58
Jiangsu Greature Bio-Medicine Co., Ltd.	0512-85557988 18662338937	frank.wang@greature.com.cn	China	145	58
Chengdu Future Element Biomaterials Co., Ltd.	18202812219	3884244356@qq.com	China	97	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69

Supplier	Advantage
Yancheng Yuntao Chemical Co., Ltd.	58
Zhejiang Sunrise Pharmaceutical Co. LTD	58
Dongyang Baihang Chemical Co., Ltd.	58
Hengshui Rayson Chemical Technology Co. , Ltd.	58
Jiangsu Greature Bio-Medicine Co., Ltd.	58
Chengdu Future Element Biomaterials Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from 2-Amino-3-hydroxypyridine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-13	2-Amino-3-hydroxypyridine 16867-03-1		0.99		RongNa Biotechnology Co.,Ltd
2026-09-11	2-Amino-3-hydroxypyridine 16867-03-1	1Kg/Bag	99%HPLC	1000KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-07	2-Amino-3-hydroxypyridine 16867-03-1	1kg	99%min	20tons	HANGZHOU HAILAN CHEMICAL CO.,LTD.

2-Amino-3-hydroxypyridine
16867-03-1
0.99
RongNa Biotechnology Co.,Ltd

2-Amino-3-hydroxypyridine
16867-03-1
99%HPLC
WUHAN FORTUNA CHEMICAL CO., LTD

2-Amino-3-hydroxypyridine
16867-03-1
$0.00
99%min
HANGZHOU HAILAN CHEMICAL CO.,LTD.

2-Amino-3-hydroxypyridine Spectrum

2-Amino-3-hydroxypyridine(16867-03-1)MS 2-Amino-3-hydroxypyridine(16867-03-1)¹HNMR 2-Amino-3-hydroxypyridine(16867-03-1)¹³CNMR 2-Amino-3-hydroxypyridine(16867-03-1)IR1 2-Amino-3-hydroxypyridine(16867-03-1)IR2 2-Amino-3-hydroxypyridine(16867-03-1)Raman

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2-Amino-3-hydroxypyridine Vetec(TM) reagent grade, 98% 2-AMINO-3-HYDROXYPYRIDINE 2-AMINO-3-PYRIDINOL 2-AMINO-3-PYRIDOL 2-AMINO-PYRIDIN-3-OL 2-amino-3-pyridi 3-HYDROXY-2-AMINOPYRIDINE 3-PYRIDINOL, 2-AMINO- 2-Aminopyridin-3-ol, 3-Hydroxypyridin-2-amine 2-amino-3-pyridino Paliperidone Impurity 25 2-amino-3-hydroxypyridine in stock Factory 3-Hydroxy-2-pyridinamine 2-Amino-3-Hydroxypyrimidine 2-AMINO-3-HYDROXYPYRIDIN 2-amino-3-haydroxypyridine -Amino-3-Hydroxypyridine 2-AMINO-3-HYDROXYPYRIDINE pure 2-AMINO-3-HYDROXYPYRIDINE 99.5% 2-AMINO-3-HYDROXYPYRIDINE 2-AMINO-PYRIDIN-3-OL 2-Amino-3-hydroxypyr 2-AMino-3-hydroxypyridine ,99% 2-AMino-3-hydroxypyridine, 98% 25GR 3-Hydroxypyridine-2-amine 2-Amino-3-hydroxypyridine,98% 2-Amino-3-hydroxypyridine,2-Amino-3-pyridinol 2-AMINO-3-HYDROXYPYRIDINE FOR SYNTHESIS 2-Amino-3-hydroxypyridine > 2-Amino-3-hydroxypyridine(2A3HP) 2-Amino-3-hydroxypyridine Solution, 100μg/mL 2-Amino-3-hydroxypyridine ISO 9001：2015 REACH 2-Amino-3-pyridinol 13C Fampridine Impurity 11 Dopexamine Impurity 14 2-Amino-3-hydroxypyridine, 10 mM in DMSO 2-Amino-3-hydroxypyridine (Standard) 16867-03-1 16867-03-01 16837-03-1 C5H6NO AMINE C5 Building Blocks Heterocyclic Building Blocks Pyridines Building Blocks C5 Chemical Synthesis Heterocyclic Building Blocks Amines Aromatics Pyridines derivates Chemical Amines Pyridines Pyridine pharmacetical Pyridines, Pyrimidines, Purines and Pteredines