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N-Carbethoxy-4-tropinone

N-Carbethoxy-4-tropinone structure

CAS No.: 32499-64-2

Chemical Name:: N-Carbethoxy-4-tropinone

Synonyms: Atropine Impurity 86;n-(carboethoxy)tropinone;N-CARBETHOXY-4-TROPINONE;N-Carbethoxy-4-nortropinone;N-(CARBOETHOXY)NORTROPINONE;N-(ETHOXYCARBONYL)TROPINONE;Ethyl 3-Oxo-8-Azabicyclo(3.;N-CARBETHOXY-4-TROPINONE,98%;N-(ETHOXYCAZBONYL)NORTROPINONE;N-(Ethoxycarbonyl)tropinone,99%

CBNumber:: CB0306544

Molecular Formula:: C10H15NO3

Molecular Weight:: 197.23

MDL Number:: MFCD00078171

MOL File:: 32499-64-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:39:00

Product description	Number	Pack Size	Price
N-(Ethoxycarbonyl)nortropinone >98.0%(GC)	E0834	5g	$125
N-(Ethoxycarbonyl)nortropinone >98.0%(GC)	E0834	25g	$499
N-Carbethoxy-4-nortropinone Asreported	270267	5g	$363
N-Carbethoxy-4-nortropinone Asreported	270267	10g	$503
N-Carbethoxy-4-nortropinone Asreported	270267	25g	$818
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N-Carbethoxy-4-tropinone Properties

Boiling point	152-153°C 11mm
Density	1.1575 (rough estimate)
refractive index	1.4876-1.4896
Flash point	152-153°C/11mm
storage temp.	Sealed in dry,Room Temperature
pka	-1.66±0.20(Predicted)
form	Liquid
color	Clear slightly yellow to light brown
BRN	1530944
CAS DataBase Reference	32499-64-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P261-P305+P351+P338

Safety Statements

24/25

HS Code

29399990

NFPA 704

	1
0		0

N-Carbethoxy-4-tropinone price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E0834	N-(Ethoxycarbonyl)nortropinone >98.0%(GC)	32499-64-2	5g	$125	2026-04-30	Buy
TCI Chemical	E0834	N-(Ethoxycarbonyl)nortropinone >98.0%(GC)	32499-64-2	25g	$499	2026-04-30	Buy
Usbiological	270267	N-Carbethoxy-4-nortropinone Asreported	32499-64-2	5g	$363	2026-06-03	Buy
Usbiological	270267	N-Carbethoxy-4-nortropinone Asreported	32499-64-2	10g	$503	2026-06-03	Buy
Usbiological	270267	N-Carbethoxy-4-nortropinone Asreported	32499-64-2	25g	$818	2026-06-03	Buy

Product number	Packaging	Price	Buy
E0834	5g	$125	Buy
E0834	25g	$499	Buy
270267	5g	$363	Buy
270267	10g	$503	Buy
270267	25g	$818	Buy

N-Carbethoxy-4-tropinone Chemical Properties,Uses,Production

Chemical Properties

CLEAR SLIGHTLY YELLOW TO LIGHT BROWN LIQUID

Synthesis

532-24-1

541-41-3

32499-64-2

To a dry 500 mL round-bottomed flask were added a stirrer, 8-methyl-8-azabicyclo[3.2.1]octan-3-one (10.0 g, 0.072 mol) and potassium carbonate (0.050 g). Anhydrous toluene (90 mL) was added, followed by slow dropwise addition of ethyl chloroformate (21 mL, 0.22 mol) via syringe. A condenser tube and nitrogen bubbler were installed and the reaction was heated to reflux with stirring overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the resulting brown oil was dissolved in dichloromethane (100 mL) and washed with water (100 mL). The organic and aqueous layers were separated in a partition funnel and the aqueous layer was extracted with dichloromethane (3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:3) to afford ethyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate (13.1 g, 92% yield) as a light yellow oil.1H NMR (δ): 4.51 (br s, 2H), 4.16 (q, J = 7.2 Hz, 2H), 2.63 (br s , 2H), 2.31 (dd, J = 17.4, 1.6 Hz, 2H), 2.07-2.03 (m, 2H), 1.65 (d, J = 7.6 Hz, 2H), 1.25 (t, J = 7.2 Hz, 3H).13C NMR (δ): 208.3, 154.1, 61.6, 53.2, 49.1, 29.5 (2), 28.8 (2), 14.8 (2), 28.8 (2), 29.5 (2), 29.5 (2), 28.8 (2), 28.8 (2), 28.8 (2), 29.5 (2) 28.8 (2), 14.9.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 629 - 632
[2] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 4, p. 569 - 574
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 24, p. 7551 - 7558
[4] Patent: CN105294674, 2016, A. Location in patent: Paragraph 0147; 0148; 0149
[5] Patent: WO2018/140876, 2018, A1. Location in patent: Page/Page column 216

N-Carbethoxy-4-tropinone synthesis

Synthesis of N-Carbethoxy-4-tropinone from Nortropan-3-one and Ethyl chloroformate

N-Carbethoxy-4-tropinone Preparation Products And Raw materials

Raw materials

8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-hydroxy-, ethyl ester, (3-endo)- Ethyl chloroformate Potassium carbonate Nortropan-3-one Tropinone

Toluene

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Preparation Products

9-Azabicyclo[3.3.1]nonane-9-carboxylic acid, 3-oxo-, ethyl ester

N-Carbethoxy-4-tropinone Suppliers

Global( 140)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	02137285211 18964703211	info@yudiaochem.com	CHINA	238	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52704	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Shanghai Yudiao Chemistry Technology Co.,Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from N-Carbethoxy-4-tropinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	N-Carbethoxy-4-tropinone 32499-64-2		1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.
2025-06-20	N-Carbethoxy-4-tropinone 32499-64-2		1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.
2021-08-12	N-Carbethoxy-4-tropinone 32499-64-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

N-Carbethoxy-4-tropinone
32499-64-2
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

N-Carbethoxy-4-tropinone
32499-64-2
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

N-Carbethoxy-4-tropinone
32499-64-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-Carbethoxy-4-tropinone Spectrum

N-Carbethoxy-4-tropinone(32499-64-2)¹HNMR

32499-64-2(N-Carbethoxy-4-tropinone)Related Search:

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Ethylparaben Oxygen-fluorine acid Tropinone Tropisetron hydrochloride Tropisetron

Levofloxacin carboxylic acid Ethyl acetate Acetophenone Ethanol (1R,3s,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane

Diethyl ether N-Boc-Nortropinone Cycloheptanone

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n-(carboethoxy)tropinone 3-Oxo-8-azabicylo[3.2.1]octane-8-carboxylic acid ethyl 3-oxo-8-azabicyclo(3.2.1)octane-8-carboxylate N-(Carboethoxy)tropinone~3-Oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid ethyl ester N-ethoxycarbonylnortropan-3-one N-(Ethoxycarbonyl)tropinone,99% N-(ETHOXYCAZBONYL)NORTROPINONE N-(Ethoxycarbonyl)nortropinone, 99% N-CARBETHOXY-4-TROPINONE,98% Ethyl 3-Oxo-8-Azabicyclo(3. N-Carbethoxy-4-nortropinone N-(CARBOETHOXY)NORTROPINONE N-(ETHOXYCARBONYL)TROPINONE N-CARBETHOXY-4-TROPINONE 3-Oxo-8-azabicylo[3.2.1]octane-8-carboxylic acid ethyl ester 8-(Ethoxycarbonyl)-8-azabicyclo[3.2.1]octan-3-one 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLIC ACID ETHYL ESTER 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-oxo-, ethyl ester N-(Ethoxycarbonyl)nortropinone 97% (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid ethyl ester ETHYL 3-OXONORTROPANE-8-CARBOXYLATE N-(Ethoxycarbonyl)nortropinone> Atropine Impurity 86 32499-64-2 C10H15NO3 Miscellaneous Biochemicals