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2-[2-(2-Chloroethoxy)ethoxy]ethanol

2-[2-(2-Chloroethoxy)ethoxy]ethanol structure

CAS No.: 5197-62-6

Chemical Name:: 2-[2-(2-Chloroethoxy)ethoxy]ethanol

Synonyms: 8-Chloro-3,6-dioxaoctane-1-ol;2-[2-(2-Chloroethoxy)ethoxy]ethanol,95%;Diethylene glycol mono(2-chloroethyl) ether;CEEE;NSC 2636;8-Chloro-3,6-dioxaoctanol;Chloroethoxyethoxy]ethanol;8-Chloro-3,6-dioxa-1-octanol;2-Chloroethoxy Ethoxy Ethanol;2-(2-CHLOROETHOXY)ETHOXYETHANOL

CBNumber:: CB0333360

Molecular Formula:: C6H13ClO3

Molecular Weight:: 168.62

MDL Number:: MFCD00002874

MOL File:: 5197-62-6.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:18

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2-[2-(2-Chloroethoxy)ethoxy]ethanol Properties

Boiling point	117-120 °C5 mm Hg(lit.)
Density	1.16 g/mL at 25 °C(lit.)
refractive index	n20/D 1.458(lit.)
Flash point	225 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly)
pka	14.36±0.10(Predicted)
form	Liquid
color	Clear slightly yellow
BRN	1739194
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C6H13ClO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-6H2
InChIKey	KECMLGZOQMJIBM-UHFFFAOYSA-N
SMILES	C(O)COCCOCCCl
CAS DataBase Reference	5197-62-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HS Code

29094990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
0		0

2-[2-(2-Chloroethoxy)ethoxy]ethanol price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	162973	2-[2-(2-Chloroethoxy)ethoxy]ethanol 96%	5197-62-6	10g	$75.2	2026-04-30	Buy
TCI Chemical	C1416	2-[2-(2-Chloroethoxy)ethoxy]ethanol >96.0%(GC)	5197-62-6	25g	$52	2026-04-30	Buy
TCI Chemical	C1416	2-[2-(2-Chloroethoxy)ethoxy]ethanol >96.0%(GC)	5197-62-6	100g	$131	2026-04-30	Buy
Usbiological	269208	2-(2-(2-Chloroethoxy)ethoxy)ethanol Asreported	5197-62-6	100g	$346	2026-06-03	Buy
Usbiological	269208	2-(2-(2-Chloroethoxy)ethoxy)ethanol Asreported	5197-62-6	250g	$506	2026-06-03	Buy

Product number	Packaging	Price	Buy
162973	10g	$75.2	Buy
C1416	25g	$52	Buy
C1416	100g	$131	Buy
269208	100g	$346	Buy
269208	250g	$506	Buy

2-[2-(2-Chloroethoxy)ethoxy]ethanol Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection.

Uses

2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end.

Synthesis

75-21-8

628-89-7

5197-62-6

The reaction material in the three-necked flask was cooled to 45-50°C and 0.7 g of boron trifluoride diethyl ether compound was added as catalyst. Subsequently, 46.2 g (1.05 mol) of ethylene oxide was slowly added under stirring conditions, and the addition rate was controlled to maintain the reaction temperature at 45-55°C, using a temperature-controlled water bath for temperature adjustment if necessary. After the addition, the reaction was continued with stirring for 0.5 h to ensure complete reaction. Upon completion of the reaction, the reaction was heated and distilled under reduced pressure to collect the middle fraction at 115-123°C (vacuum 10 mmHg) to obtain a colorless transparent liquid. Further vacuum distillation was carried out under reduced pressure to collect the middle fraction at 118-121 °C (vacuum 10 mmHg) to give 123.6 g of colorless transparent liquid with 97.7% purity in the gas phase and 73.3% overall yield.

References

[1] Patent: CN104003850, 2016, B. Location in patent: Paragraph 0039; 0040

2-[2-(2-Chloroethoxy)ethoxy]ethanol synthesis

Synthesis of 2-[2-(2-Chloroethoxy)ethoxy]ethanol from Triethylene glycol

2-[2-(2-Chloroethoxy)ethoxy]ethanol Preparation Products And Raw materials

Raw materials

2-Chloroethanol 2-(2-Chloroethoxy)ethanol Triethylene glycol Ethylene oxide Ethylene glycol

Preparation Products

2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethanol 1,4-Dioxane NH2-PEG3-OH t-Boc-N-Amido-PEG3-propargyl Acetic acid, [2-[2-(2-aminoethoxy)ethoxy]ethoxy]-

1,4,7,10,13-Pentaoxa-16-azacyclooctadecane 2-[2-(2-Azidoethoxy)ethoxy]ethanol 1,2-Bis(2-chloroethoxy)ethane

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2-[2-(2-Chloroethoxy)ethoxy]ethanol Suppliers

Global( 216)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Honghanyanxin Pharm	0551-62626652 19334025048	sales-honghanyanxin@aliyun.com	China	1448	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57

Supplier	Advantage
Honghanyanxin Pharm	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Chemsky（shanghai）International Co.,Ltd.	50
Syntechem Co.,Ltd	57

View Lastest Price from 2-[2-(2-Chloroethoxy)ethoxy]ethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-02-25	2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6	$10.00	1KG	99%	5000kg/month	Shanxi Naipu Import and Export Co.,Ltd
2021-08-12	2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL 5197-62-6	$1.00	1KG	98%	100KG	Career Henan Chemical Co

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
5197-62-6
$10.00
99%
Shanxi Naipu Import and Export Co.,Ltd

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
5197-62-6
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL
5197-62-6
$1.00
98%
Career Henan Chemical Co

2-[2-(2-Chloroethoxy)ethoxy]ethanol Spectrum

2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)MS 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)¹HNMR 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)¹³CNMR 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)IR1 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL(5197-62-6)Raman

5197-62-6(2-[2-(2-Chloroethoxy)ethoxy]ethanol)Related Search:

Diethylene glycol bis(2-chloroethyl) ether 2-[2-(2-Chloroethoxy)ethoxy]ethanol α-Chloralose beta-Chloralose 1-(2-Chloro-ethoxy)-2-(2-methoxy-ethoxy)-ethane

1,2,3-Tri-O-benzoyl-α-L-fucopyranose, trichloroacetimidate [2-(2-Methoxy-ethoxy)-ethoxy]-acetyl chloride 2-(2-hydroxyethoxy)ethyl chloroacetate 1-[2-Hydroxy-7-(trichloromethyl)-4,6,8-trioxabicyclo[3.3.0]oct-3-yl]ethane-1,2-diol Methyl (2-O-beta-D-glucopyranosyl)-4,6-dichloro-alpha-D-galactopyranoside

5-Chloroacetoxy-2-benzyloxyisosorbide 3,4,6-Tri-O-acetyl-2-O-(2',3',4'-tri-O-benzoyl-α-L-fucopyranosyl)-galactopyranosyl trichloroacetimidate 6-Chloro-2,2-dimethylperhydro[1,3]dioxolo[4',5':4,5]furo[3,2-b]pyran-5-one amicloral AURORA KA-6932

LABOTEST-BB LT00455823 AURORA KA-6933 LABOTEST-BB LT00112361

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2-[2-(2-Chloroethoxy)ethoxy]ethanol,95% 8-Chloro-3,6-dioxa-1-octanol 8-Chloro-3,6-dioxaoctanol NSC 2636 2-[2-(2-Chloroethoxy)ethoxy]ethanol 96% 2-(2-CHLOROETHOXY)ETHOXYETHANOL TRIETHYLENE GLYCOL MONOCHLOROHYDRIN Triethylene glycol monochloride 2-[2-(2-CHLOROETHOXY)ETHOXY]ETHANOL, 96+% Chloroethoxyethoxy]ethanol CEEE 2-[2-(2-Chloroethoxy)ethoxy]ethanol > Ethanol, 2-[2-(2-chloroethoxy)ethoxy]- 2-Chloroethoxy Ethoxy Ethanol 2-[2-(2-chloroethoxy)ethoxy]ethan-1-ol 2-Chloroethoxy-2-ethoxydiethanol 8-Chloro-3,6-dioxaoctane-1-ol Diethylene glycol mono(2-chloroethyl) ether 2-[2-(2-Chloroethoxy)ethoxy]ethanol 5197-62-6 C6H13ClO3 ClCH2CH2O2CH2CH2OH Monofunctional Ethylene Glycols Ethylene Glycols & Monofunctional Ethylene Glycols Organic Building Blocks Oxygen Compounds C2 to C6 Alcohols Building Blocks Aliphatics Intermediates Polyethyleneglycol Derivatives Ethylene Glycols & Monofunctional Ethylene Glycols Monofunctional Ethylene Glycols