(Boc-aminooxy)acetic Acid
- CAS No.
- 42989-85-5
- Chemical Name:
- (Boc-aminooxy)acetic Acid
- Synonyms
- BOC-AOAC-OH;BOC-AOA;2-(BOC-AMINOOXY)-ACETIC ACID;BOC-AOA-OH;BOC-(NHOAC)-OH;BOC-NH-O-CH2COOH;RARECHEM EM WB 0063;N-Boc-(carboxymethox;(BOC-AMINOOXY)ACETIC ACID;T-BOC-AMINOOXYACETIC ACID
- CBNumber:
- CB0356387
- Molecular Formula:
- C7H13NO5
- Molecular Weight:
- 191.18
- MDL Number:
- MFCD01632027
- MOL File:
- 42989-85-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~115 °C (dec.) |
|---|---|
| Density | 1.214±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 2.97±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| BRN | 6137646 |
| InChI | InChI=1S/C7H13NO5/c1-7(2,3)13-6(11)8-12-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10) |
| InChIKey | QBXODCKYUZNZCY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CONC(OC(C)(C)C)=O |
| CAS DataBase Reference | 42989-85-5(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2928 00 90 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
(Boc-aminooxy)acetic Acid price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.51017 | Boc-amino-oxyacetic acid Novabiochem? | 42989-85-5 | 1g | $82.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.51017 | Boc-amino-oxyacetic acid Novabiochem? | 42989-85-5 | 5G | $334 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15035 | (Boc-aminooxy)acetic acid ≥98.0% (T) | 42989-85-5 | 1g | $280 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15035 | (Boc-aminooxy)acetic acid ≥98.0% (T) | 42989-85-5 | 5g | $654 | 2026-04-30 | Buy |
| TCI Chemical | B3338 | [(tert-Butoxycarbonyl)aminooxy]acetic Acid >98.0%(T) | 42989-85-5 | 1g | $22 | 2026-04-30 | Buy |
(Boc-aminooxy)acetic Acid Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
(Boc-aminooxy)acetic acid was employed to introduce a hydroxylamine moiety into peptides; reaction with an aldehyde to an oxime. It was used in the preparation of Boc-aminooxy tetra(ethylene glycol).
Uses
(Boc-aminooxy)acetic acid was used in the preparation of Boc-aminooxy tetra(ethylene glycol).
Uses
A Boc-protected bifunctional linking reagent
reaction suitability
reagent type: ligand
Synthesis
(Boc-aminooxy)acetic acid is prepared by the reaction of Di-tert-butyl dicarbonate and Aminooxyacetic acid. The specific synthesis steps are as follows:
A 500 mL round-bottom flask was charged with a suspension of aminooxyacetic acid (4 g, 36.6 mmol) in CH2Cl2 (100 mL).
The solution was cooled to 0° C. and triethylamine (16 mL, 114 mmol) was added dropwise while stiffing to dissolve all solids.
To this mixture was added a solution of di-tert-butyl dicarbonate (12 g, 55 mmol) in CH2Cl2 (20 mL).
The reaction was stirred for 30 min at 0° C., then continued for 1 h at rt.
The solution was washed with three 100 mL portions of water.
The aqueous portion was combined and extracted with two 100 mL portions of EtOAc; this EtOAc was discarded.
The pH of the aqueous portion was adjusted to 3.5 with 1 M HCl, then extracted with five 50 mL portions of EtOAc, adjusting to maintain pH 3.5 as needed.
The combined EtOAc was dried over Na2SO4, filtered, and the solvent removed in vacuo to afford a white crystalline powder (5.8 g, 83percent). TLC: (MeOH:CH2Cl2, 1:9) Rf=0.08. 1H NMR (400 MHz, CD3OD): δ 1.48 (s, 9H), 4.47 (s, 2H), 7.94 (s, 1H).
13C NMR (100 MHz, CD OD): δ, 27.1, 47.0, 72.3, 81.4, 157.8, 171.3.
Solubility in organics
Soluble in DCM, THF, DMF and DMSO
References
[1] Patent: US2015/344924, 2015, A1. Location in patent: Paragraph 0632; 0633
(Boc-aminooxy)acetic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1846 | 58 |
| Shanghai Jifeng Biotechnology Co., Ltd. | 021-61263377 15023907684 | 15800684150@163.com | China | 7994 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from (Boc-aminooxy)acetic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-04 | (Boc-aminooxy)acetic Acid
42989-85-5
|
1KG | 99% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | (BOC-AMINOOXY)ACETIC ACID
42989-85-5
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
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2024-09-26 | Boc-AOATert-Boc-aminooxyacetic acid
42989-85-5
|
100g | 98% | 1000kg/Month | Xiamen Yunfan Biotech Co.,Ltd. |
-
- (Boc-aminooxy)acetic Acid
42989-85-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- (BOC-AMINOOXY)ACETIC ACID
42989-85-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Boc-AOATert-Boc-aminooxyacetic acid
42989-85-5
- 98%
- Xiamen Yunfan Biotech Co.,Ltd.
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