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N-Benzyloxycarbonyl-L-proline

N-Benzyloxycarbonyl-L-proline structure

CAS No.: 1148-11-4

Chemical Name:: N-Benzyloxycarbonyl-L-proline

Synonyms: Z-PRO-OH;CBZ-PRO-OH;Z-Pro;CBZ-L-PROLINE;N-CBZ-L-PROLINE;CBZ-L-Pro;Z-L-PRO-OH;Z-PROLINE;CBZ-L-Pro-OH;carbobenzoxyproline

CBNumber:: CB0370381

Molecular Formula:: C13H15NO4

Molecular Weight:: 249.26

MDL Number:: MFCD00003170

MOL File:: 1148-11-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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N-Benzyloxycarbonyl-L-proline Properties

Melting point	75-77 °C
alpha	-60 º (c=2,AcOH)
Boiling point	392.36°C (rough estimate)
Density	1.1952 (rough estimate)
refractive index	-40 ° (C=2, EtOH)
storage temp.	Sealed in dry,Room Temperature
solubility	Solubility in methanol, almost transparency.
form	Crystalline Powder or Crystals
pka	3.99±0.20(Predicted)
color	White to off-white
optical activity	[α]20/D 42°, c = 2 in ethanol
BRN	88579
Major Application	peptide synthesis
InChI	InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
InChIKey	JXGVXCZADZNAMJ-NSHDSACASA-N
SMILES	N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(O)=O
CAS DataBase Reference	1148-11-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	H2BS8M5FPP
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P271-P261-P280

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

62-36/37/38-20/21/22

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

UY0745000

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Benzyloxycarbonyl-L-proline price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C8601	Z-Pro-OH 99%	1148-11-4	10g	$163	2026-04-30	Buy
TCI Chemical	C0713	N-Carbobenzoxy-L-proline >98.0%(HPLC)(T)	1148-11-4	5g	$20	2026-04-30	Buy
TCI Chemical	C0713	N-Carbobenzoxy-L-proline >98.0%(HPLC)(T)	1148-11-4	25g	$30	2026-04-30	Buy
Usbiological	264205	N-Benzyloxycarbonyl-L-proline Asreported	1148-11-4	100g	$333	2026-06-03	Buy
Usbiological	264205	N-Benzyloxycarbonyl-L-proline Asreported	1148-11-4	250g	$475	2026-06-03	Buy

Product number	Packaging	Price	Buy
C8601	10g	$163	Buy
C0713	5g	$20	Buy
C0713	25g	$30	Buy
264205	100g	$333	Buy
264205	250g	$475	Buy

N-Benzyloxycarbonyl-L-proline Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powder

Uses

N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.

Preparation

Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.

reaction suitability

reaction type: solution phase peptide synthesis

N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

Z-Pro-NH2 2-(1-Adamantyl)propan-2-ol H-DL-Pro-NH2 Z-Pro-ONp H-Pro-Tyr-OH

Benzyl 2-carbamoylpyrrolidine-1-carboxylate Z-Pro-betana 1-[(Phenylmethoxy)carbonyl]-L-prolyl-β-alanine Methyl Ester Benzyl (S)-(-)-2-(1-pyrrolidinylcarbonyl)-1-pyrrolidinecarboxylate

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N-Benzyloxycarbonyl-L-proline Suppliers

Global Suppliers ( 550)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Shanxi Bethlehem Pharm-Tech Co.,Ltd.	19135651983 19135651206	243332738@qq.com	China	959	58
Wuxi Jingyao Bio-Technology Co., Ltd.	88770633 13961738808	jingyaobiotech@126.com	China	389	55
Jinan Dexinjia Bio&Tech Co., Ltd	0531-82375880 15098789112	3845379039@qq.com	China	1457	58
Nanjing Ally Chemical S&T Co., Ltd.	025-025-58367986 18913956109	amy.xiang@ally-chem.com	China	662	58
Yangzhou Xuda Biotechnology Co., Ltd	15161820588; 15161820588	xdchemical2024@163.com	China	91	58
Organic Bio-Tech (Suzhou) Co.,Ltd	18061997750	info@organic-Biotechnology.com	China	192	58
Shanxi Nuocheng Biotechnology Co., Ltd	17835231871	572710841@qq.com	China	7939	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62

Supplier	Advantage
Shanghai Hobor Chemical Co., Ltd	60
Shanxi Bethlehem Pharm-Tech Co.,Ltd.	58
Wuxi Jingyao Bio-Technology Co., Ltd.	55
Jinan Dexinjia Bio&Tech Co., Ltd	58
Nanjing Ally Chemical S&T Co., Ltd.	58
Yangzhou Xuda Biotechnology Co., Ltd	58
Organic Bio-Tech (Suzhou) Co.,Ltd	58
Shanxi Nuocheng Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62

View Latest Price from N-Benzyloxycarbonyl-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	N-Benzyloxycarbonyl-L-proline 1148-11-4		10g	99%min	100kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-17	Cbz-L-Pro-OH 1148-11-4		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-02	Z-Pro-OH 1148-11-4	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd

N-Benzyloxycarbonyl-L-proline
1148-11-4
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Cbz-L-Pro-OH
1148-11-4
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

Z-Pro-OH
1148-11-4
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

N-Benzyloxycarbonyl-L-proline Spectrum

N-Benzyloxycarbonyl-L-proline(1148-11-4)MS N-Benzyloxycarbonyl-L-proline(1148-11-4)¹HNMR N-Benzyloxycarbonyl-L-proline(1148-11-4)IR1 N-Benzyloxycarbonyl-L-proline(1148-11-4)IR2 N-Benzyloxycarbonyl-L-proline(1148-11-4)Raman

1148-11-4 (N-Benzyloxycarbonyl-L-proline) Related Search:

Trimethoprim cis-4-Hydroxy-L-proline L-Proline D-Proline N-Carbobenzyloxyglycine

N-Cbz-L-Serine L-Proline-(4-3H(n)) Z-Pro-Gly-OH Z-Pro-Phe-OH N-Cbz-L-glutamic acid

N-Cbz-L-Phenylalanine N-Cbz-L-Threonine N-Cbz-L-Tryptophan Z-Pro-NH2 Z-Pro-Pro-OH

Z-Pro-betana Z-Pro-Gly-NH2 Z-Pro-ONp

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n-benzyloxycarbonylproline N-Benzyloxycarbonyl-L-proline~Z-Pro-OH N-cbz-L-proline crystalline N-CBZ-L-Proline N-Carbobenzyloxy-L-proline N-Cbz-L-Pro-OH CBZ-L-Pro-OH N-Benzyloxycarbonyl-L-proline, 98+% L-Cbz-ProlineN Z-L-PROLINE extrapure N-Cbz-L-proline, 98+% (S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L- N-[(Phenylmethoxy)carbonyl]-L-proline N-Benzyloxycarbonyl-(S)-proline (2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester (2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester N-Carbobenzyloxy-L-proline,99% (2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid N-Carbobenzyloxy-L-proline, 99% 10GR N-Cbz-L-proline Z-Pro-OH (2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid (S)-N-Benzyloxycarbonyl-L-proline 1-benzylester,l-2-pyrrolidinedicarboxylicacid benzyloxycarbonylproline carbobenzoxy-l-proline carbobenzoxy-s-proline Z-Pro-OH 99% l-1,2-pyrrolidinedicarboxylicacid1-benzylester 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- 1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid (S)-Z-pyrrolidine-2-carboxylic acid Z-L-proline≥ 99% (HPLC) 1-[(BENZYLOXY)CARBONYL]-L-PROLINE 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)- (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID L-CBZ-PROLINE CARBOBENZYLOXY-L-PROLINE (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID N-BENZYLOXYCARBONYL-L-PROLINE N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-CARBOBENZOXY-L-PROLINE N-ALPHA-CBZ-L-PROLINE N-CBZ-L-PROLINE-OH N-CARBOBENZYLOXY-L-PROLINE Z-PYRD(2)-OH Z-L-PRO-OH 1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid N-Carbobenzoxy-L-proline > (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylicaci N-Benzyloxycarbonyl-L-proline USP/EP/BP N-BENZYLOXYCARBONY-L-PROLIN TIANFU CHEM N-Benzyloxycarbonyl-L-proline Fmoc-Thr(Ac?AcNH-α-Gal)-OH ZINC77292789 N-(benzyloxycarbonyl)-L-proine N-Benzyloxycarbonyl-L-proline ( N-CBZ-L-PROLINE) N-Cbz-L-proline, 99% [Z-Pro-OH]