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N-Benzyloxycarbonyl-L-proline

N-Benzyloxycarbonyl-L-proline Structure
N-Benzyloxycarbonyl-L-proline structure
CAS No.
1148-11-4
Chemical Name:
N-Benzyloxycarbonyl-L-proline
Synonyms
Z-PRO-OH;CBZ-PRO-OH;Z-Pro;CBZ-L-PROLINE;N-CBZ-L-PROLINE;CBZ-L-Pro;Z-L-PRO-OH;Z-PROLINE;CBZ-L-Pro-OH;carbobenzoxyproline
CBNumber:
CB0370381
Molecular Formula:
C13H15NO4
Molecular Weight:
249.26
MDL Number:
MFCD00003170
MOL File:
1148-11-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
Z-Pro-OH 99% C8601 10g $163
N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) C0713 5g $20
N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) C0713 25g $30
N-Benzyloxycarbonyl-L-proline Asreported 264205 100g $333
N-Benzyloxycarbonyl-L-proline Asreported 264205 250g $475
More product size
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N-Benzyloxycarbonyl-L-proline Properties

Melting point 75-77 °C
alpha -60 º (c=2,AcOH)
Boiling point 392.36°C (rough estimate)
Density 1.1952 (rough estimate)
refractive index -40 ° (C=2, EtOH)
storage temp. Sealed in dry,Room Temperature
solubility Solubility in methanol, almost transparency.
form Crystalline Powder or Crystals
pka 3.99±0.20(Predicted)
color White to off-white
optical activity [α]20/D 42°, c = 2 in ethanol
BRN 88579
Major Application peptide synthesis
InChI InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
InChIKey JXGVXCZADZNAMJ-NSHDSACASA-N
SMILES N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(O)=O
CAS DataBase Reference 1148-11-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII H2BS8M5FPP
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P271-P261-P280
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xn
Risk Statements  62-36/37/38-20/21/22
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  UY0745000
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

N-Benzyloxycarbonyl-L-proline price More Price(117)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C8601 Z-Pro-OH 99% 1148-11-4 10g $163 2026-04-30 Buy
TCI Chemical C0713 N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) 1148-11-4 5g $20 2026-04-30 Buy
TCI Chemical C0713 N-Carbobenzoxy-L-proline >98.0%(HPLC)(T) 1148-11-4 25g $30 2026-04-30 Buy
Usbiological 264205 N-Benzyloxycarbonyl-L-proline Asreported 1148-11-4 100g $333 2026-06-03 Buy
Usbiological 264205 N-Benzyloxycarbonyl-L-proline Asreported 1148-11-4 250g $475 2026-06-03 Buy
Product number Packaging Price Buy
C8601 10g $163 Buy
C0713 5g $20 Buy
C0713 25g $30 Buy
264205 100g $333 Buy
264205 250g $475 Buy

N-Benzyloxycarbonyl-L-proline Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

N-(Benzyloxycarbonyl)-L-proline is a potent in vitro and in vivo inhibitor of prolidase; a specific peptidase that cleaves dipeptides with a C-terminal prolyl and hydroxylprolyl residue. It is also used in the synthesis of N-(L-Prolyl)-β-alanine which is a derivative of the naturally occurring beta amino acid β-Alanine.

Preparation

Caution! All procedures must be carried out in an efficient fume cupboard, wearing latex gloves and chemical-proof safety goggles. ι-Proline (10.0 g, 8.7 mmol) was dissolved in 2 m sodium hydroxide solution (40 mL), and the solution was cooled to ice-water temperature. Z-Cl (20.5 g, 12 mmol) was added portionwise, with vigorous stirring or occasional shaking, over a period of 30 min at 0–5 °C to the solution of l-proline. The ice bath was then removed and stirring or occasional shaking was continued for 30 min while the reaction mixture warmed to room temperature. The mixture was then acidified to Congo red by the gradual addition of concentrated hydrochloric acid, and the oil was extracted into ethyl acetate. The extract was dried over magnesium sulfate, the mixture was filtered, and the filtrate was concentrated in vacuo. The residue was extracted/triturated with warm tetrachloromethane. The washings were decanted and the residue was further purified by recrystallization from ethyl acetate/petroleum ether.

reaction suitability

reaction type: solution phase peptide synthesis

N-Benzyloxycarbonyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

Z-PRO-NH2 2-(1-Adamantyl)propan-2-ol H-DL-PRO-NH2 Z-PRO-ONP H-PRO-TYR-OH
BENZYL 2-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE Z-PRO-BETANA 1-[(Phenylmethoxy)carbonyl]-L-prolyl-β-alanine Methyl Ester BENZYL (S)-(-)-2-(1-PYRROLIDINYLCARBONYL)-1-PYRROLIDINECARBOXYLATE

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N-Benzyloxycarbonyl-L-proline Suppliers

Global( 542)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-17392712779 1097@dideu.com China 3992 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+86-15680023009 ni@enlaibio.com China 1103 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20120 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8615821988213 info@longyupharma.com China 2430 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Fengjia New Material Co., Ltd 		58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58

View Lastest Price from N-Benzyloxycarbonyl-L-proline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cbz-L-Pro-OH pictures 2026-07-31 Cbz-L-Pro-OH
1148-11-4
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
N-Benzyloxycarbonyl-L-proline pictures 2026-07-31 N-Benzyloxycarbonyl-L-proline
1148-11-4
 10g 99%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD
Carbobenzoxyproline pictures 2026-07-27 Carbobenzoxyproline
1148-11-4
 $29.00 99.79% 10g TargetMol Chemicals Inc.

N-Benzyloxycarbonyl-L-proline Spectrum

N-Benzyloxycarbonyl-L-proline(1148-11-4)MSN-Benzyloxycarbonyl-L-proline(1148-11-4)1HNMRN-Benzyloxycarbonyl-L-proline(1148-11-4)IR1N-Benzyloxycarbonyl-L-proline(1148-11-4)IR2N-Benzyloxycarbonyl-L-proline(1148-11-4)Raman

1148-11-4(N-Benzyloxycarbonyl-L-proline)Related Search:

L-PROLINE-(4-3H(N)) Trimethoprim cis-4-Hydroxy-L-proline L-Proline D-Proline
N-Carbobenzyloxyglycine Z-PRO-GLY-OH N-Cbz-L-Serine Z-PRO-PHE-OH N-alpha-Benzyloxycarbonyl-L-proline amide
N-Cbz-L-Threonine N-Cbz-L-Tryptophan N-Cbz-L-Phenylalanine N-Cbz-L-glutamic acid Z-PRO-GLY-NH2
Z-PRO-BETANA Z-PRO-PRO-OH Z-PRO-ONP

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n-benzyloxycarbonylproline N-Benzyloxycarbonyl-L-proline~Z-Pro-OH N-cbz-L-proline crystalline N-CBZ-L-Proline N-Carbobenzyloxy-L-proline N-Cbz-L-Pro-OH CBZ-L-Pro-OH N-Benzyloxycarbonyl-L-proline, 98+% L-Cbz-ProlineN Z-L-PROLINE extrapure N-Cbz-L-proline, 98+% (S)-1-(Benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L- N-[(Phenylmethoxy)carbonyl]-L-proline N-Benzyloxycarbonyl-(S)-proline (2S)-1,2-Pyrrolidinedicarboxylic acid 1-benzyl ester (2S)-1,2-Pyrrolidinedicarboxylic acid hydrogen 1-benzyl ester N-Carbobenzyloxy-L-proline,99% (2S)-Pyrrolidine-2-carboxylic acid, N-CBZ protected L-Proline, N-CBZ protected, (2S)-1-[(Benzyloxy)carbonyl]pyrrolidine-2-carboxylic acid N-Carbobenzyloxy-L-proline, 99% 10GR N-Cbz-L-proline Z-Pro-OH (2S)-1-[(benzyloxy)carbonyl]-2-pyrrolidinecarboxylic acid (S)-N-Benzyloxycarbonyl-L-proline 1-benzylester,l-2-pyrrolidinedicarboxylicacid benzyloxycarbonylproline carbobenzoxy-l-proline carbobenzoxy-s-proline Z-Pro-OH 99% l-1,2-pyrrolidinedicarboxylicacid1-benzylester 1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- 1-[oxo-(phenylmethoxy)methyl]-2-pyrrolidinecarboxylic acid (S)-Z-pyrrolidine-2-carboxylic acid Z-L-proline≥ 99% (HPLC) 1-[(BENZYLOXY)CARBONYL]-L-PROLINE 1,2-PYRROLIDINEDICARBOXYLIC ACID, 1-(PHENYLMETHYL) ESTER, (2S)- (2S)-1-[(BENZYLOXY)CARBONYL]PYRROLIDINE-2-CARBOXYLIC ACID L-CBZ-PROLINE CARBOBENZYLOXY-L-PROLINE (S)-N-CBZ-PYRROLIDINE-2-CARBOXYLIC ACID N-BENZYLOXYCARBONYL-L-PROLINE N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-CARBOBENZOXY-L-PROLINE N-ALPHA-CBZ-L-PROLINE N-CBZ-L-PROLINE-OH N-CARBOBENZYLOXY-L-PROLINE Z-PYRD(2)-OH Z-L-PRO-OH 1-(phenylmethyl)ester,(s)-2-pyrrolidinedicarboxylicacid N-Carbobenzoxy-L-proline > (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylicaci N-Benzyloxycarbonyl-L-proline USP/EP/BP N-BENZYLOXYCARBONY-L-PROLIN TIANFU CHEM N-Benzyloxycarbonyl-L-proline Fmoc-Thr(Ac?AcNH-α-Gal)-OH ZINC77292789 N-(benzyloxycarbonyl)-L-proine N-Benzyloxycarbonyl-L-proline ( N-CBZ-L-PROLINE) N-Cbz-L-proline, 99% [Z-Pro-OH]