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Z-PRO-NH2

Z-PRO-NH2 structure

CAS No.: 34079-31-7

Chemical Name:: Z-PRO-NH2

Synonyms: Z-L-P;Z-PRO-NH2;CBZ-PRO-NH2;Z-L-Pro-NH2;Z-PROLINE-NH2;Z-PYRD(2)-NH2;CBZ-L-PRO NH2;Z-L-PROLINAMIDE;Z-Pro-Nh2 92.5%;Z-L-PROLINE AMIDE

CBNumber:: CB7212019

Molecular Formula:: C13H16N2O3

Molecular Weight:: 248.28

MDL Number:: MFCD00020830

MOL File:: 34079-31-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:26:48

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Z-PRO-NH2 Properties

Melting point	90-95℃
Boiling point	465.6±44.0 °C(Predicted)
Density	1.263±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	soluble in Methanol
pka	15.95±0.20(Predicted)
form	Solid
color	White to Almost white
Major Application	peptide synthesis
InChI	InChI=1S/C13H16N2O3/c14-12(16)11-7-4-8-15(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H2,14,16)/t11-/m0/s1
InChIKey	ZCGHEBMEQXMRQL-NSHDSACASA-N
SMILES	N1(C(OCC2=CC=CC=C2)=O)CCC[C@H]1C(N)=O
CAS DataBase Reference	34079-31-7(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	36
WGK Germany	3
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Z-PRO-NH2 price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	663220	Z-L-Prolinamide 97%	34079-31-7	1g	$95.8	2023-06-20	Buy
Sigma-Aldrich	663220	Z-L-Prolinamide 97%	34079-31-7	5g	$417	2023-06-20	Buy
TCI Chemical	C3005	N-Carbobenzoxy-L-prolinamide >98.0%(HPLC)(N)	34079-31-7	5g	$46	2026-04-30	Buy
TCI Chemical	C3005	N-Carbobenzoxy-L-prolinamide >98.0%(HPLC)(N)	34079-31-7	25g	$144	2026-04-30	Buy
Usbiological	287783	Z-L-proline amide Asreported	34079-31-7	10g	$353	2026-06-03	Buy

Product number	Packaging	Price	Buy
663220	1g	$95.8	Buy
663220	5g	$417	Buy
C3005	5g	$46	Buy
C3005	25g	$144	Buy
287783	10g	$353	Buy

Z-PRO-NH2 Chemical Properties,Uses,Production

Chemical Properties

White crystals

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1148-11-4

34079-31-7

General procedure for the synthesis of (S)-1-N-benzyloxycarbonylproline from N-benzyloxycarbonyl-L-proline: 1-{[(phenylmethyl)oxy]carbonyl}-L-proline (8.0 g, 32.09 mmol) was solubilized in 1,4-dioxane (40 mL), and pyridine (1.5 mL) and di-tert-butyl dicarbonate ((Boc)2O, 9.1 g 41.72 mmol). Ammonium bicarbonate (3.2 g, 40.43 mmol) was then added. The reaction mixture was stirred at room temperature overnight and then diluted with ethyl acetate (100 mL) and washed sequentially with water (50 mL) and 5% sulfuric acid (H2SO4). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by distillation under reduced pressure to give a clarified oil. The oily material was ground with ether, the precipitate was collected by filtration and dried under vacuum to afford (S)-1-N-Benzyloxycarbonylprolinamide as a white solid (3.9 g, 49% yield). The mass spectrum showed [M+H]+ of 249.

References

[1] Organic and Biomolecular Chemistry, 2005, vol. 3, # 1, p. 84 - 96
[2] Synlett, 2004, # 3, p. 558 - 560
[3] Patent: WO2005/121135, 2005, A1. Location in patent: Page/Page column 240-241
[4] Canadian Journal of Chemistry, 2007, vol. 85, # 2, p. 85 - 95
[5] Journal of the American Chemical Society, 2018, vol. 140, # 5, p. 1627 - 1631

Z-PRO-NH2 synthesis

Synthesis of Z-PRO-NH2 from Benzyl chloroformate

Z-PRO-NH2 Preparation Products And Raw materials

Raw materials

Z-PRO-ALA-OH Z-PRO-GLY-OH Z-Pro-ONp N-Benzyloxycarbonyl-L-proline L-Prolinamide

L-Proline (S)-benzyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate Benzyl chloroformate Pyridine Dibemethine

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Preparation Products

Z-PRO-NH2 Suppliers

Global( 225)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64

View Lastest Price from Z-PRO-NH2 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-08-05	Z-PRO-NH2 34079-31-7	$1.00	1Kg	98%	20T	Shaanxi Dideu Medichem Co. Ltd
2023-10-22	Z-PRO-NH2 34079-31-7		1drums	99%min.	10tons	Shanghai Xinchem Co., Ltd.
2019-07-06	Z-PRO-NH2 34079-31-7	$100.00	1KG	99		Career Henan Chemical Co

Z-PRO-NH2
34079-31-7
$1.00
98%
Shaanxi Dideu Medichem Co. Ltd

Z-PRO-NH2
34079-31-7
99%min.
Shanghai Xinchem Co., Ltd.

Z-PRO-NH2
34079-31-7
$100.00
99
Career Henan Chemical Co

34079-31-7(Z-PRO-NH2)Related Search:

Z-PRO-GLY-NH2 Z-PHE-NH2 N-Benzyloxycarbonyl-L-proline Z-PRO-ONP Z-PHG-OH

Cbz-L-Threonine benzyl ester Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate Z-TYR-OH Z-Pyr-OH Z-Sar-OH

Z-Pro-OSu Z-Trp-OSu Z-PRO-PHE-OH Z-Pro-Pro-OH Z-Pro-Gly-OH

Z-Pro-betana Ac-L-Pro-NH2 Nα-[[(S)-4-Oxo-2-azetidinyl]carbonyl]-L-His-L-Pro-NH2,Nα-[(S)-4-Oxo-2-azetidinyl]carbonyl-L-His-L-Pro-NH2

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N-ALPHA-CARBOBENZOXY-L-PYRROLIDINE-2-CARBOXYLIC ACID ALPHA-AMIDE N-ALPHA-CARBOBENZOXY-L-PROLINE AMIDE N-CARBOBENZOXY-L-PROLINE AMIDE (S)-2-CARBAMOYL-1-CBZ-PYRROLIDINE (S)-2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER (S)-1-N-CBZ-PROLINAMIDE Z-L-PROLINAMIDE Z-L-PROLINE AMIDE Z-PYRD(2)-NH2 Z-PROLINE-NH2 Z-PRO-NH2 2-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER CARBOBENZYLOXY-L-PROLINAMIDE CBZ-PRO-NH2 CBZ-L-PROLINAMIDE CBZ-L-PRO NH2 BENZYLOXYCARBONYL-L-PROLINAMIDE N-BENZYLOXYCARBONYL-L-PROLINAMIDE N-alpha-Benzyloxycarbonyl-L-proline amide Z-L-Pro-NH2 benzyl (2S)-2-carbamoylpyrrolidine-1-carboxylate Z-Pro-Nh2 92.5% N-Carbobenzyloxy-L-Prolinamide 1-(Benzyloxycarbonyl)-L-prolinamide 1-Benzyloxycarbonyl-L-prolinamide Z-L-P (2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid (S)-benzyl 2-carbamoylpyrrolidine-1-carboxylate (S)-1-Carbobenzoxypyrrolidine-2-carboxamide Benzyloxycarbonyl-L-proline aMide 1-Pyrrolidinecarboxylicacid, 2-(aMinocarbonyl)-, phenylMethyl ester, (2S)- N-Carbobenzoxy-L-prolinamide (S)-Z-pyrrolidine-2-carboxylic acid amide Z-L-proline amide98 - 102% (Assay) N-Carbobenzoxy-L-prolinamide > N-Cbz-L-prolinamide Cbz-l-proline amide / N-benzyloxycarbonyl L-proline amide Benzyl (S)-2-carbamoylpyrrolidine-1-carboxylate Z-L-Prolinamide (S)-1-Cbz-2-carbamoylpyrrolidine 34079-31-7 Proline [Pro, P] Z-Amino Acids and Derivatives Z-Amino acid series