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N-Cbz-L-Tryptophan

N-Cbz-L-Tryptophan Structure
N-Cbz-L-Tryptophan structure
CAS No.
7432-21-5
Chemical Name:
N-Cbz-L-Tryptophan
Synonyms
Z-Trp;CBZ-TRP-OH;Z-TRP-OH;Cbz-L-Try-OH;N-CARBOBENZOXY-L-TRYPTOPHAN;Cbz-Trp;Z-L-TRP-OH;NSC 521831;Z-TRYPTOPHAN;CBZ-L-TRP-OH
CBNumber:
CB1284456
Molecular Formula:
C19H18N2O4
Molecular Weight:
338.36
MDL Number:
MFCD00065700
MOL File:
7432-21-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:26:03
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N-Cbz-L-Tryptophan Properties

Melting point 124-127 °C(lit.)
alpha 2.5 º (c=3, EtOH)
Boiling point 474.51°C (rough estimate)
Density 1.2855 (rough estimate)
refractive index 1.6140 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility methanol: 0.1 g/mL, clear
pka 3.98±0.10(Predicted)
form Solid
color White
optical activity [α]20/D +2.9±0.3°, c = 3% in acetic acid
BRN 96743
CAS DataBase Reference 7432-21-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
HS Code  29339900
NFPA 704
0
0 0

N-Cbz-L-Tryptophan price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 97240 Z-Trp-OH 97% 7432-21-5 25g $73.8 2021-12-16 Buy
TCI Chemical C0638 N-Carbobenzoxy-L-tryptophan >98.0%(HPLC)(T) 7432-21-5 5g $22 2026-04-30 Buy
TCI Chemical C0638 N-Carbobenzoxy-L-tryptophan >98.0%(HPLC)(T) 7432-21-5 25g $59 2026-04-30 Buy
Usbiological 461084 Nα-Cbz-L-tryptophan 7432-21-5 25g $403 2026-06-03 Buy
Usbiological 461084 Nα-Cbz-L-tryptophan 7432-21-5 100g $785 2026-06-03 Buy
Product number Packaging Price Buy
97240 25g $73.8 Buy
C0638 5g $22 Buy
C0638 25g $59 Buy
461084 25g $403 Buy
461084 100g $785 Buy

N-Cbz-L-Tryptophan Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powder

Uses

Nα-Cbz-L-tryptophan is an N-Cbz-protected form of L-Tryptophan (T947210). L-Tryptophan is an essential amino acid that is important for cell proliferation and the biosynthesis of proteins. It is a precursor to Serotonin (HCl: S274980), a neurotransmitter that compound that aids in sleep and mental state. L-Tryptophan is also thought to cause eosinophilia-myalgia syndrome.

Synthesis

Benzyl chloroformate

501-53-1

L-Tryptophan

73-22-3

N-Cbz-L-Tryptophan

7432-21-5

L-tryptophan (10.24 g, 50 mmol) was dissolved in 1 M aqueous sodium hydroxide solution (50 mL) and stirred at 0 °C. Subsequently, benzyl chloroformate (7.15 mL, 50.1 mmol) was added slowly and dropwise into the reaction system simultaneously with 1 M aqueous sodium hydroxide solution (50 mL). After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1 hour. After completion of the reaction, the reaction solution was acidified to pH 1 with 6 M hydrochloric acid, and then the target product was extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give a yellow solid product (16.72 g, 99% yield), which could be used in the next reaction without further purification. The analytical data of the product were as follows: thin layer chromatography (TLC) Rf value of 0.43 (unfolding agent ratio of 95:4:1 dichloromethane/methanol/acetic acid); melting point (Mp): 132-134 °C; 1H NMR (DMSO-d6, 400 MHz) δ: 7.57-7.53 (m, 2H), 7.35-7.22 (m, 6H), 7.16- 7.15 (m, 1H), 7.09-7.04 (m, 1H), 7.00-6.95 (m, 1H), 5.02-4.92 (m, 2H), 4.28-4.21 (m, 1H), 3.22-3.16 (m, 1H), 3.04-2.96 (m, 1H); 13C NMR (DMSO-d6, 100 MHz) δ : 174.2, 156.5, 137.4, 136.6, 128.8, 128.2, 128.0, 127.6, 124.2, 121.4, 118.8, 118.6, 111.9, 110.5, 65.8, 55.5, 27.4; low resolution mass spectrometry (LRMS, ESI+): C19H19N2O4 [M+ H]+ calculated value 339.13, measured value 339.35.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 47, p. 6430 - 6432
[2] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[3] Synthesis, 1986, # 11, p. 958 - 960
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 462 - 473
[5] Patent: CN105884674, 2016, A. Location in patent: Paragraph 0085; 0086; 0087

N-Cbz-L-Tryptophan Preparation Products And Raw materials

Raw materials

N-Cbz-D-Tryptophan N-Cbz-DL-tryptophan Benzyl chloroformate L-Tryptophan Sodium hydroxide
Water

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Preparation Products

Z-Trp-ONp Z-Trp-Ala-OH

N-Cbz-L-Tryptophan Suppliers

Global Suppliers ( 309)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Sichuan Tongsheng Amino acids Co.,Ltd. 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66

View Latest Price from N-Cbz-L-Tryptophan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Cbz-L-Tryptophan pictures 2026-09-18 N-Cbz-L-Tryptophan
7432-21-5
 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
N-Cbz-L-Tryptophan pictures 2026-03-20 N-Cbz-L-Tryptophan
7432-21-5
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
N-Cbz-L-Tryptophan pictures 2024-04-28 N-Cbz-L-Tryptophan
7432-21-5
 $50.00 1kg 99.10% 50000kg Ouhuang Engineering Materials (Hubei) Co., Ltd

N-Cbz-L-Tryptophan Spectrum

N-Cbz-L-Tryptophan(7432-21-5)MSN-Cbz-L-Tryptophan(7432-21-5)13CNMRN-Cbz-L-Tryptophan(7432-21-5)IR1N-Cbz-L-Tryptophan(7432-21-5)IR2

7432-21-5 (N-Cbz-L-Tryptophan) Related Search:

Z-Trp-OEt L-Tryptophan Benzyloxyacetyl chloride Trimethoprim Z-Trp-OBzl
Z-Trp-ONp N-Cbz-L-methionine N-Cbz-L-Aspartic acid 4-benzyl ester N-Cbz-L-Leucine Z-Trp-Lys(Boc)-NH2
tert-butyl N-[(5S)-6-amino-5-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-6-oxohexyl]carbamate N-Cbz-L-glutamic acid N-Cbz-L-Phenylalanine N-Carbobenzyloxyglycine N-Cbz-L-Threonine
N-Benzyloxycarbonyl-L-proline Z-Trp(Boc)-OH dcha Z-Trp-NH2

1of4

BENZYLOXYCARBONYL-L-TRYPTOPHAN CBZ-L-TRYPTOPHAN Z-L-TRP-OH Z-L-TRYPTOPHAN Z-TRYPTOPHAN N-CBZ-L-TRYPTOPHAN N-CBZ-L-TRYPTOPHAN-OH N-ALPHA-BENZYLOXYCARBONYL-L-TRYPTOPHAN N-BENZYLOXYCARBONYL-L-TRYPTOPHAN N-ALPHA-CARBOBENZOXY-L-TRYPTOPHAN N-ALPHA-CARBOBENZYLOXY-L-TRYPTOPHAN N(ALPHA)-CBZ-L-TRYPTOPHAN Nα-Carbobenzyloxy-L-tryptophan N-α-Z-L-tryptophan N(a)-Benzyloxycarbonyl-L-tryptophan N-(Benzyloxycarbonyl)tryptophan Nα-Z-L-tryptophan99% N-CBZ-L-TRYPTOPHAN CRYSTALLINE CBZ-L-TRP-OH N-Benzyloxycarbonyl-L-tryptophane n(à)-benzyloxycarbonyl-l-tryptophan n(à)-cbz-l-tryptophan CBZ-L-TRYPTOPHAN-OH benzyloxycarbonyltryptophan N-ALPHA-BENZYLOXYCARBONYL-L-TRYPTOPHANE Cbz-L-Tryptphan N-Carbobenzyloxy-L-tryptophan N(ɑ)-Benzyloxycarbonyl-L-tryptophan, 98+% N-Carbobenzyloxy-L-tryptphan Nalpha-Carbobenzyloxy-L-tryptophan,99% N(alpha)-Benzyloxycarbonyl-L-tryptophan, 98+% Z-L-TRYPTOPHAN extrapure N-Cbz-L-tryptophan, Nα-Carbobenzyloxy-L-tryptophan, Z-L-Tryptophan (2S)-3-(1H-Indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoic acid L-Tryptophan, N-[(phenylmethoxy)carbonyl]- (S)-2-[[(Benzyloxy)carbonyl]amino]-3-(1H-indole-3-yl)propanoic acid (S)-α-[[(Benzyloxy)carbonyl]amino]-1H-indole-3-propionic acid N-(Benzyloxycarbonyl)-3-(1H-indole-3-yl)-L-alanine N(^a)-Benzyloxycarbonyl-L-tryptophan, 98+% (S)-2-(((Benzyloxy)carbonyl)aMino)-3-(1H-indol-3-yl)propanoic acid NSC 521831 N-Cbz-L-tryptophan Z-Trp-OH (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(1H-indol-3-yl)propanoic acid (2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoate N-Carbobenzoxy-L-tryptophan > (2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoicaci N-Cbz-L-Tryptophan USP/EP/BP Nα-Z-L-tryptophan Nα-Cbz-L-tryptophan Nα -Cbz-L-tryptophan, 98% [Z-Trp-OH] Cbz-Trp Cbz-L-Try-OH CBZ-TRP-OH N-CARBOBENZOXY-L-TRYPTOPHAN Z-TRP-OH Z-Trp Na-Cbz-L-tryptophan 7432-21-5