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N-Cbz-L-Threonine

N-Cbz-L-Threonine structure

CAS No.: 19728-63-3

Chemical Name:: N-Cbz-L-Threonine

Synonyms: Z-THR-OH;CBZ-THR-OH;Z-Thr;Z-L-THREONINE;N-CARBOBENZOXY-L-THREONINE;Z-L-Thr;Cbz-Thr;Z-L-THR-OH;Z-THREONINE;CBZ-L-THR-OH

CBNumber:: CB1434499

Molecular Formula:: C12H15NO5

Molecular Weight:: 253.25

MDL Number:: MFCD00065948

MOL File:: 19728-63-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:34:46

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N-Cbz-L-Threonine Properties

Melting point	101-103 °C(lit.)
Boiling point	396.45°C (rough estimate)
alpha	-4.7 º (c=4, acetic acid)
Density	1.2499 (rough estimate)
refractive index	-4.9 ° (C=2, AcOH)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	almost transparency in Methanol
form	powder to crystal
pka	3.58±0.10(Predicted)
color	White to Almost white
optical activity	-7.733° (C=1.00 g/100ml, ACOH)
BRN	2335409
Major Application	peptide synthesis
InChI	1S/C12H15NO5/c1-8(14)10(11(15)16)13-12(17)18-7-9-5-3-2-4-6-9/h2-6,8,10,14H,7H2,1H3,(H,13,17)(H,15,16)/t8-,10+/m1/s1
InChIKey	IPJUIRDNBFZGQN-SCZZXKLOSA-N
SMILES	C[C@@H](O)[C@H](NC(=O)OCc1ccccc1)C(O)=O
CAS DataBase Reference	19728-63-3(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

HS Code

29242990

Storage Class

13 - Non Combustible Solids

NFPA 704

	1
0		0

N-Cbz-L-Threonine price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C1351	N-Carbobenzoxy-L-threonine >98.0%(HPLC)(T)	19728-63-3	10g	$111	2026-04-30	Buy
Usbiological	458492	N-Cbz-L-threonine	19728-63-3	1g	$403	2026-06-03	Buy
Usbiological	458492	N-Cbz-L-threonine	19728-63-3	10g	$516	2026-06-03	Buy
Usbiological	290879	Z-L-Thr-OH Asreported	19728-63-3	10g	$352	2026-06-03	Buy
Usbiological	290879	Z-L-Thr-OH Asreported	19728-63-3	25g	$486	2026-06-03	Buy

Product number	Packaging	Price	Buy
C1351	10g	$111	Buy
458492	1g	$403	Buy
458492	10g	$516	Buy
290879	10g	$352	Buy
290879	25g	$486	Buy

N-Cbz-L-Threonine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Cbz-L-threonine is an N-Cbz-protected form of L-Threonine (T405500). L-Threonine is an essential amino acid that is commonly used as a feed and food additive. L-Threonine is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body (such as hemoglobin and insulin).

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Add L-Thr (30 mmol), 50 mL of cooled saturated Na2CO3 solution in a 250 mL reaction vial, dissolve with ice bath stirring; drop 20 mL of acetone solution of Z-OSu (39.4 mmol) into the reaction vial; stir the reaction at 25C, and monitor the progress of the reaction by TLC-ultraviolet fluorescence and ninhydrin colorimetry. At the end of the reaction, H2O was added. After the reaction, add H2O , extract with Et2O(30mL2) at pH>9, collect the aqueous phase, adjust the pH to 3~4 with 1.5NHCl, extract with EtOAc(30mL3), merge the organic phases, wash with saturated NaCl solution(25mL2), dry with anhydrous Na2SO4, check the purity with TLC-ultraviolet fluorescence and ninhydrin colorimetric method, dry with evaporation under reduced pressure, dry in vacuum, get a light yellow color. Vacuum drying, obtained slightly yellow oily liquid N-Benzyloxycarbonyl-L-threonine, low temperature preservation.

N-Cbz-L-Threonine Preparation Products And Raw materials

Raw materials

Preparation Products

Z-Thr-OSu Z-Thr(TBDMS)-OH

N-Cbz-L-Threonine Suppliers

Global Suppliers ( 351)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66

View Latest Price from N-Cbz-L-Threonine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	Cbz-Thr-OH 19728-63-3		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-03-20	N-Cbz-L-Threonine 19728-63-3	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2024-04-29	N-Cbz-L-Threonine 19728-63-3	$50.00	1kg	99.10%	50000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd

Cbz-Thr-OH
19728-63-3
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Cbz-L-Threonine
19728-63-3
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

N-Cbz-L-Threonine
19728-63-3
$50.00
99.10%
Ouhuang Engineering Materials (Hubei) Co., Ltd

N-Cbz-L-Threonine Spectrum

N-Cbz-L-Threonine(19728-63-3)MS N-Cbz-L-Threonine(19728-63-3)¹HNMR N-Cbz-L-Threonine(19728-63-3)¹³CNMR N-Cbz-L-Threonine(19728-63-3)IR1 N-Cbz-L-Threonine(19728-63-3)IR2

19728-63-3 (N-Cbz-L-Threonine) Related Search:

L-Threonine N-Carbobenzyloxyglycine tert-Butyl carbazate CBZ-L-THREONINE AMIDE N-CBZ-L-THREONINE BENZYL ESTER,Cbz-L-Threonineα-benzylester

CBZ-L-THREONINE METHYL ESTER Z-Thr-OEt Z-L-THREONINOL N-alpha-Cbz-L-lysine Carbonyl sulfide

Pyrazophos Z-Thr(Bzl)-OH Z-Phg-OH (3S)-2-Carbobenzoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Z-Thr-OSu

N-Cbz-L-glutamic acid N-Cbz-L-Phenylalanine N-Cbz-L-Tryptophan

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N-ALPHA-BENZYLOXYCARBONYL-L-THREONINE Z-L-THREONINE Z-L-THR-OH Z-THREONINE Z-L-Thr Z-L-threonine≥ 98% (HPLC) N-CARBOBENZYLOXY-L-THREONINE N-CBZ-L-THREONINE-OH N-CBZ-L-THREONINE N-BENZYLOXYCARBONYL-L-THREONINE N-ALPHA-CBZ-L-THREONINE N-ALPHA-CARBOBENZOXY-L-THREONINE N-Cbz-L-threonine Z-Thr-OH (2S)-2-{[(benzyloxy)carbonyl]aMino}-3-hydroxybutanoic acid (2S,3R)-2-(((benzyloxy)carbonyl)aMino)-3-hydroxybutanoic acid CBZ-L-Threonine(Z-L-Thr-OH) N-CARBOBENZYLOXY-L-THREONINE 98% CARBOBENZYLOXY-L-THREONINE 3-Hydroxy-2-(phenylmethoxycarbonylamino)butanoic acid L-Threonine, N-[(phenylmethoxy)carbonyl]- N-CARBOBENZYLOXY-L-THREONINE, 99+% Z-L-THREONINE extrapure N-Carbobenzyloxy-L-threonine, N-Cbz-L-threonine, Z-L-Threonine N-Z-L-threonine CBZ-L-THREONINE CBZ-L-THR-OH BENZYLOXYCARBONYL-L-THREONINE (2S,3R)-3-hydroxy-2-(phenylmethoxycarbonylamino)butanoic acid N-Carbobenzoxy-L-threonine > (2S,3R)-3-hydroxy-2-(phenylmethoxycarbonylamino)butanoicaci N-Cbz-L-Threonine USP/EP/BP N-Cbz-L-threonine, 99% [Z-Thr-OH] N-Benzyloxycarbonyl-L-threonine, 98%min CBZ-THR-OH N-CARBOBENZOXY-L-THREONINE Z-THR-OH Z-Thr Cbz-Thr 19728-63-3 CH3CHOHCHNHCOOCH2C6H5COOH Amino Acids (N-Protected) Cbz-Amino Acids Protected & Labeled Amino Acids CARBOXYLIC ACID Amino Acid Derivatives Specialty Synthesis Threonine Peptide Synthesis Cbz-Amino acid series Chiral Compounds Threonine [Thr, T] Z-Amino Acids and Derivatives Amino Acids Amino Acids (N-Protected) Biochemistry Cbz-Amino Acids Protected Amino Acids PROTECTED AMINO ACID & PEPTIDES