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2-Fluoro-4-methylbenzonitrile

2-Fluoro-4-methylbenzonitrile Structure
2-Fluoro-4-methylbenzonitrile structure
CAS No.
85070-67-3
Chemical Name:
2-Fluoro-4-methylbenzonitrile
Synonyms
2-Fluoro-4-methylben;2-Fluoro-p-tolunitrile;4-Cyano-3-fluorotoluene;2-FLUORO-4-METHYLBENZONITRILE;2-Fluoro-4-methylbenzonitirile;2-Fluoro-4-methylbenzonitrile>Benzonitrile, 2-fluoro-4-methyl-;2-Fluoro-4-methylbenzonitrile98%;2-Fluoro-4-methylbenzonitrile 98%;2-Fluoro-4-Methylbenzenecarbonitrile
CBNumber:
CB0388885
Molecular Formula:
C8H6FN
Molecular Weight:
135.14
MDL Number:
MFCD03094311
MOL File:
85070-67-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:38:47
Product description Number Pack Size Price
2-Fluoro-4-methylbenzonitrile >98.0%(GC) F0884 1g $33
2-Fluoro-4-methylbenzonitrile >98.0%(GC) F0884 5g $99
2-Fluoro-4-methylbenzonitrile 98% PC5912 5g $21
2-Fluoro-4-methylbenzonitrile 98% PC5912 25g $77
2-Fluoro-4-methylbenzonitrile 98% PC5912 100g $229
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2-Fluoro-4-methylbenzonitrile Properties

Melting point 52-53°C
Boiling point 219.6±20.0 °C(Predicted)
Density 1.11±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
color White to Orange to Green
Water Solubility Insoluble in water, soluble in chloroform, acetone and other organic solvents.
InChI InChI=1S/C8H6FN/c1-6-2-3-7(5-10)8(9)4-6/h2-4H,1H3
InChIKey WCGNLBCJPBKXCN-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(C)C=C1F
CAS DataBase Reference 85070-67-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Exclamation Mark (GHS07)
GHS06,GHS07
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H302-H312-H331-H335
Precautionary statements  P304+P340-P305+P351+P338-P501a-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501
Hazard Codes  T,Xi
Risk Statements  37/38-41-36/37/38-20/21/22
Safety Statements  26-39-36/37-9
RIDADR  UN3439
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29269090
NFPA 704
1
2 0

2-Fluoro-4-methylbenzonitrile price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F0884 2-Fluoro-4-methylbenzonitrile >98.0%(GC) 85070-67-3 1g $33 2026-04-30 Buy
TCI Chemical F0884 2-Fluoro-4-methylbenzonitrile >98.0%(GC) 85070-67-3 5g $99 2026-04-30 Buy
Apolloscientific PC5912 2-Fluoro-4-methylbenzonitrile 98% 85070-67-3 5g $21 2026-06-04 Buy
Apolloscientific PC5912 2-Fluoro-4-methylbenzonitrile 98% 85070-67-3 25g $77 2026-06-04 Buy
Apolloscientific PC5912 2-Fluoro-4-methylbenzonitrile 98% 85070-67-3 100g $229 2026-06-04 Buy
Product number Packaging Price Buy
F0884 1g $33 Buy
F0884 5g $99 Buy
PC5912 5g $21 Buy
PC5912 25g $77 Buy
PC5912 100g $229 Buy

2-Fluoro-4-methylbenzonitrile Chemical Properties,Uses,Production

Chemical Properties

Off white crystalline

Uses

2-Fluoro-4-methylbenzonitrile is used in the synthesis of fluorobenzamidrazone thrombin inhibitors.

Synthesis

4-Bromo-3-fluorotoluene

452-74-4

Copper(I) Cyanide

544-92-3

2-Fluoro-4-methylbenzonitrile

85070-67-3

Example 59 Preparation of 2-fluoro-4-methylbenzonitrile: 3-fluoro-4-bromotoluene (70 g, 370 mmol) and cuprous cyanide (50 g, 555 mmol) were dissolved in N,N-dimethylformamide (300 mL), heated to reflux and maintained for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of concentrated ammonia (300 mL) and ether (200 mL) with continuous stirring for 1 hour. The reaction mixture was extracted with ether (3 x 200 mL). All organic phases were combined and washed sequentially with saturated saline (3 x 200 mL) and dried over anhydrous sodium sulfate. Finally, the solvent was removed by distillation under reduced pressure to afford the light yellow solid product 2-fluoro-4-methylbenzonitrile (44 g, 88% yield). Mass spectrometry analysis showed a molecular ion peak (M + H)+ of 136.

References

[1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 9, p. 1339 - 1352
[2] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2925 - 2930
[3] Patent: WO2007/76092, 2007, A2. Location in patent: Page/Page column 74
[4] Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 7, p. 1135 - 1139
[5] Zhurnal Organicheskoi Khimii, 1992, vol. 28, # 7, p. 1439 - 1444

2-Fluoro-4-methylbenzonitrile Preparation Products And Raw materials

Raw materials

4-Bromo-3-fluorotoluene Copper(I) Cyanide

Preparation Products

4-(BROMOMETHYL)-2-FLUOROBENZONITRILE [4-methyl-2-(propan-2-yloxy)phenyl]methanamine 4-(DIBROMOMETHYL)-2-FLUOROBENZONITRILE 1,6-DiMethylindazol-3-aMine 3-CYANO-4-FLUOROPHENYLACETIC ACID

2-Fluoro-4-methylbenzonitrile Suppliers

Global( 251)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+86-15350571055 Sibel@chuanghaibio.com China 8737 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 809 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2971 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58

View Lastest Price from 2-Fluoro-4-methylbenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-4-methylbenzonitrile pictures 2026-03-20 2-Fluoro-4-methylbenzonitrile
85070-67-3
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Fluoro-4-methylbenzonitrile pictures 2021-08-12 2-Fluoro-4-methylbenzonitrile
85070-67-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2-Fluoro-4-methylbenzonitrile pictures 2021-07-13 2-Fluoro-4-methylbenzonitrile
85070-67-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoro-4-methylbenzonitrile Spectrum

2-Fluoro-4-methylbenzonitrile(85070-67-3)1HNMR

85070-67-3(2-Fluoro-4-methylbenzonitrile)Related Search:

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Benzotrifluoride Fluorine 4-(Aminomethyl)-2-fluorobenzonitrile 4-CYANO-2,3,5,6-TETRAFLUOROBENZOTRIFLUORIDE 2-Fluoro-4-(trifluoromethyl)benzonitrile
4-Cyano-3-fluorobenzoic acid Benzonitrile, 2,3-difluoro-4-methyl- (9CI) 3-Fluoro-4-methylbenzonitrile

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Benzonitrile, 2-fluoro-4-methyl- (9CI) 2-Fluoro-4-methylbenzonitrile 98% 2-Fluoro-4-methylbenzonitrile98% 2-FLUORO-4-METHYLBENZONITRILE 2-Fluoro-4-methylbenzonitirile 2-Fluoro-4-methylben 4-Cyano-3-fluorotoluene 2-Fluoro-4-Methylbenzenecarbonitrile 4-Cyano-3-fluorotoluene, 2-Fluoro-p-tolunitrile Benzonitrile, 2-fluoro-4-methyl- 2-Fluoro-4-methylbenzonitrile> 2-Fluoro-p-tolunitrile 85070-67-3 850-70-3 Fluorine series NITRILE Fluorin-contained Benzonitrile series Miscellaneous