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6-Methylpyridazin-3(2H)-one

6-Methylpyridazin-3(2H)-one structure

CAS No.: 13327-27-0

Chemical Name:: 6-Methylpyridazin-3(2H)-one

Synonyms: 6-METHYL-3(2H)-PYRIDAZINONE;6Me3OxoPyridaz;SPECS AC-907/25005370;6-Methyl-3-pyridazone;6-Methyl-3-pyridazinone;6-Methylpyridazin-3-one;3-pyridazinol, 6-methyl-;3-methyl-1H-pyridazin-6-one;6-METHYL-2H-PYRIDAZIN-3-ONE;6-METHYLPYRIDAZIN-3[2H]-ONE

CBNumber:: CB0463313

Molecular Formula:: C5H6N2O

Molecular Weight:: 110.11

MDL Number:: MFCD00039720

MOL File:: 13327-27-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:41:22

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6-Methylpyridazin-3(2H)-one Properties

Melting point	143-145°C
Density	1.22±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	11.51±0.40(Predicted)
form	powder to crystal
color	Light yellow to Amber to Dark green
BRN	109928
InChI	InChI=1S/C5H6N2O/c1-4-2-3-5(8)7-6-4/h2-3H,1H3,(H,7,8)
InChIKey	QZWIXLPWMGHDDD-UHFFFAOYSA-N
SMILES	C1(=O)NN=C(C)C=C1
CAS DataBase Reference	13327-27-0(CAS DataBase Reference)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

22-24/25-37-26

WGK Germany

WGK 3

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

6-Methylpyridazin-3(2H)-one price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2344	6-Methyl-3(2H)-pyridazinone >98.0%(GC)	13327-27-0	1g	$16	2023-06-20	Buy
TCI Chemical	M2344	6-Methyl-3(2H)-pyridazinone >98.0%(GC)	13327-27-0	5g	$48	2023-06-20	Buy
Apolloscientific	OR5828	3-Hydroxy-6-methylpyridazine >98%	13327-27-0	5g	$21	2026-06-04	Buy
Apolloscientific	OR5828	3-Hydroxy-6-methylpyridazine >98%	13327-27-0	25g	$24	2026-06-04	Buy
Apolloscientific	OR5828	3-Hydroxy-6-methylpyridazine >98%	13327-27-0	100g	$62	2026-06-04	Buy

Product number	Packaging	Price	Buy
M2344	1g	$16	Buy
M2344	5g	$48	Buy
OR5828	5g	$21	Buy
OR5828	25g	$24	Buy
OR5828	100g	$62	Buy

6-Methylpyridazin-3(2H)-one Chemical Properties, Uses, Production

Uses

6-Methylpyridazin-3(2H)-one is a lignin-based dye used on wool. It is also used as a reactant for the synthesis of C-(1-aryl-cyclohexyl)-methylamine derivatives as selective, orally available inhibitors of dipeptidyl peptidase IV, imidazopyridazinone derivatives as PDE7 inhibitors and pyridazinone derivatives with an arylpiperazinylalkyl chain as a potentent, orally active, antinociceptive agent.

Definition

ChEBI: 6-Methylpyridazin-3(2H)-one is a member of pyridazines.

Synthesis Reference(s)

Synthesis, p. 1158, 1994 DOI: 10.1055/s-1994-25663

Synthesis

5157-08-4

13327-27-0

General procedure for the synthesis of 6-methyl-3(2H)-pyridazinone from 4,5-dihydro-6-methylpyridazin-3(2H)-one: bromine (7.68 g, 48.05 mmol) was added slowly and dropwise to a solution of 6-methyl-4,5-dihydropyridazin-3(2H)-one (9.0 g, 80.26 mmol) in acetic acid (90 mL) at 90 °C. The reaction mixture was stirred continuously at 90 °C for 5-6 hours. Upon completion of the reaction, the excess acetic acid was removed by distillation under reduced pressure. The resulting residue was neutralized with aqueous sodium bicarbonate solution, followed by filtration to collect the solid product. The filter cake was dried to give the title compound 6-methyl-3(2H)-pyridazinone (6.0 g, 68% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.73 (s, 1H), 7.30 (d, J = 9.6 Hz, 1H), 6.80 (d, J = 9.9 Hz, 1H), 2.14 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6286 - 6291
[2] Journal of Chemical Research, Miniprint, 1995, # 8, p. 1840 - 1852
[3] Journal of the Chemical Society, 1947, p. 239,242
[4] Patent: US4595521, 1986, A

6-Methylpyridazin-3(2H)-one Preparation Products And Raw materials

Raw materials

4,5-Dihydro-6-methylpyridazin-3(2H)-one Furfuryl alcohol

Preparation Products

3-bromo-6-methylpyridazine 6-Chloro-pyridazine-3-carboxylic acid ethyl ester 3-Mercapto-6-methylpyridazine

6-Methylpyridazin-3(2H)-one Suppliers

Global Suppliers ( 249)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianyuan Natural Product Co.,Ltd.	028-85012281 13808177790	xianlihong8888@163.com	China	45	62
Nanjing Jubai Biomedical Technology Co., Ltd.	13585203734	info@jbzml.com	China	200	58
Changzhou HCK Biotech Co., Ltd.	18796480679 15295163861	3844328290@qq.com	China	602	58
Shanghai Pulikang Chemical Technology Co., Ltd	13105330140 13105330140	icyan@126.com	China	266	58
Nanbu County Chengxin Technology Co., Ltd.	0838-5675166 15883665058	nbcxkj@126.com	China	956	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Tianyuan Natural Product Co.,Ltd.	62
Nanjing Jubai Biomedical Technology Co., Ltd.	58
Changzhou HCK Biotech Co., Ltd.	58
Shanghai Pulikang Chemical Technology Co., Ltd	58
Nanbu County Chengxin Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66

View Latest Price from 6-Methylpyridazin-3(2H)-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	6-Methylpyridazin-3(2H)-one 13327-27-0	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-03-20	6-Methylpyridazin-3(2H)-one 13327-27-0	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	6-Methylpyridazin-3(2H)-one 13327-27-0		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

6-Methylpyridazin-3(2H)-one
13327-27-0
$1.10
99.00%
Dideu Industries Group Limited

6-Methylpyridazin-3(2H)-one
13327-27-0
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

6-Methylpyridazin-3(2H)-one
13327-27-0
98%
Henan Aochuang Chemical Co.,Ltd.

6-Methylpyridazin-3(2H)-one Spectrum

6-Methylpyridazin-3(2H)-one(13327-27-0)MS 6-Methylpyridazin-3(2H)-one(13327-27-0)¹HNMR 6-Methylpyridazin-3(2H)-one(13327-27-0)IR1 6-Methylpyridazin-3(2H)-one(13327-27-0)IR2

13327-27-0 (6-Methylpyridazin-3(2H)-one) Related Search:

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6-Methyl-2,3-dihydropyridazine-3-one 3-pyridazinol, 6-methyl- 3-methyl-1H-pyridazin-6-one 6-Methyl-2H-pyridazin-3-o... 3-Hydroxy-6-methylpyridazine 6-Methylpyridazine-3[2H]-one 6-Methyl-1,2-dihydropyriMidin-2-one 6-Methyl-3-pyridazinone 6-Methyl-2H-pyridazine-3-one hydrobrMide salt 4-ChlorothiobenzaMide, 97%, 97% 6-Methyl-3(2H)-pyridazinone,98% 6Me3OxoPyridaz 6-Methyl-3(2H)-pyridazinone SPECS AC-907/25005370 6-METHYL-2H-PYRIDAZIN-3-ONE 6-METHYLPYRIDAZIN-3[2H]-ONE 3(2H)-Pyridazinone,6-methyl- 6-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE 6-Methylpyridazin-3-one 6-Methylpyridazin-32Hü-one, 98% 6-Methyl-3-pyridazone 3-Hydroxy-6-methylpyridazine 97% 6-Methyl-3(2H)-pyridazinone> 6-Methylpyridazin-3(2H)-one ISO 9001：2015 REACH 6-Methyl-3-pyridazinone-98% 6-methyl-3 (2H) - pyridazine ketone 6-METHYL-3(2H)-PYRIDAZINONE 13327-27-0