4,7-Dichloroquinazoline
- CAS No.
- 2148-57-4
- Chemical Name:
- 4,7-Dichloroquinazoline
- Synonyms
- 4,7-Dichloroquizoline;7-dichloroquinazoline;4,7-DICHLOROQUINAZOLINE;Quinazoline, 4,7-dichloro-;4,7-
Dichloroquinazoline;4,7-dichloro-4a,8a-dihydroquinazoline
- CBNumber:
- CB3358665
- Molecular Formula:
- C8H4Cl2N2
- Molecular Weight:
- 199.04
- MDL Number:
- MFCD00023911
- MOL File:
- 2148-57-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
4,7-Dichloroquinazoline price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S671487 | 4,7-Dichloroquinazoline AldrichCPR | 2148-57-4 | 1 unit | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | S671487 | 4,7-Dichloroquinazoline AldrichCPR | 2148-57-4 | 50MG | $110 | 2024-03-01 | Buy |
| Apolloscientific | OR951087 | 4,7-Dichloroquinazoline 99% | 2148-57-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR951087 | 4,7-Dichloroquinazoline 99% | 2148-57-4 | 5g | $36 | 2026-06-04 | Buy |
| Apolloscientific | OR951087 | 4,7-Dichloroquinazoline 99% | 2148-57-4 | 25g | $172 | 2026-06-04 | Buy |
4,7-Dichloroquinazoline Chemical Properties, Uses, Production
Uses
4,7-Dichloroquinazoline is a useful building block, used in the synthesis of aroylquinazolines via aroylation with aryl aldehydes. 4,7-Dichloroquinazoline has been identified as a dengue virus entry inhibitor.
Synthesis
31374-18-2
2148-57-4
The general procedure for the synthesis of 4,7-dichloroquinazoline from 7-chloro-4(3H)-quinazolinone was as follows: 7-chloro-3H-quinazolin-4-one (170, 0.155 g, 0.85830 mmol) was dissolved in a screw cap vial containing 1 mL of phosphorus oxychloride (POCl3). After sealing the vial, the reaction was placed in an oil bath at 100 °C for 3 hours. Upon completion of the reaction, the resulting solution was concentrated under vacuum and distilled three times by azeotropic distillation with toluene to completely remove the residual phosphorous trichloride, resulting in the target compound 4,7-dichloroquinazoline (171, 0.162 g, 0.81391 mmol, 94.828% yield). The mass spectrometry analysis showed m/z 199.0 ([M+H]+).
References
[1] Patent: WO2013/142613, 2013, A1. Location in patent: Page/Page column 175
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980, vol. 19, # 12, p. 1084 - 1087
[4] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 545 - 548
[5] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
4,7-Dichloroquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD | 15528092102 | Pharmsynth@hotmail.com | China | 116 | 60 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
View Latest Price from 4,7-Dichloroquinazoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-12 | 4,7-Dichloroquinazoline
2148-57-4
|
$3500.00 | 1Kg | 99 % | 500 Kg | R&D Scientific Inc. | |
 |
2019-07-11 | 4,7-Dichloroquinazoline
2148-57-4
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 4,7-Dichloroquinazoline
2148-57-4
- $3500.00
- 99 %
- R&D Scientific Inc.
-
- 4,7-Dichloroquinazoline
2148-57-4
- $8.80
- 97%-99%
- Career Henan Chemical Co
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