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Elenbecestat(E2609)

Elenbecestat(E2609) Structure
Elenbecestat(E2609) structure
CAS No.
1388651-30-6
Chemical Name:
Elenbecestat(E2609)
Synonyms
Elenbecestat(E26090;Elenbecestat(E2609);Elenbecestat, 10 mM in DMSO;Alzheimer's disease,inhibit,Beta-secretase,E-2609,Inhibitor,Elenbecestat,E 2609,β-Secretase,BACE-1,BACE;N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide;2-Pyrazinecarboxamide, N-[3-[(4aS,5R,7aS)-2-amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)-;N-[3-[(4aS,5R,7aS)-2-Amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)-2-pyrazinecarboxamide (ACI)
CBNumber:
CB04868677
Molecular Formula:
C19H18F3N5O2S
Molecular Weight:
437.44
MDL Number:
MOL File:
1388651-30-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
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Elenbecestat(E2609) Properties

Density 1.61±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 250 mg/mL (571.51 mM)
pka 9.06±0.70(Predicted)
form Solid
color Light yellow to yellow
FDA UNII RXJ96XL94H

Elenbecestat(E2609) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth NFC65130 Elenbecestat 1388651-30-6 10mg $740.7 2026-06-04 Buy
Biosynth NFC65130 Elenbecestat 1388651-30-6 25mg $1388.5 2026-06-04 Buy
Biosynth NFC65130 Elenbecestat 1388651-30-6 50mg $2221.5 2026-06-04 Buy
ChemScene CS-0031645 Elenbecestat 99.82% 1388651-30-6 5mg $206 2026-06-04 Buy
ChemScene CS-0031645 Elenbecestat 99.82% 1388651-30-6 10mg $347 2026-06-04 Buy
Product number Packaging Price Buy
NFC65130 10mg $740.7 Buy
NFC65130 25mg $1388.5 Buy
NFC65130 50mg $2221.5 Buy
CS-0031645 5mg $206 Buy
CS-0031645 10mg $347 Buy

Elenbecestat(E2609) Chemical Properties, Uses, Production

Uses

Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research[1][2].

in vivo

Elenbecestat (E2609; 0.3-30 mg/kg; p.o.) potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF of non-human primates[2].
Elenbecestat displays the plasma half-life of 12-16 hours after once daily dosing[1].

Animal Model:Cynomolgus monkeys (Pharmacokinetic analysis)[2]
Dosage:0.3 mg/kg; 1 mg/kg; 3 mg/kg; 30 mg/kg
Administration:Oral administration
Result:Potently inhibits Ab1-40 and Ab1-42 production in the plasma and CSF.

IC 50

BACE1

References

[1] Kumar D, et al.Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead. Eur J Med Chem. 2018 Mar 25;148:436-452. DOI:10.1016/j.ejmech.2018.02.035
[2] A single dose of the beta-secretase inhibitor, e2609, decreases CSF bace1 enzymatic activity in cynomolgus monkeys. Alzheimer’s & Dementia, 8(4), P224.

Elenbecestat(E2609) Preparation Products And Raw materials

Raw materials

Preparation Products

Elenbecestat(E2609) Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Wuhan Sun-shine Bio-technology Corporation Limited +86-027-6552-2453 sales@sun-shinechem.com China 725 58
Jinan Carbotang Biotech Co.,Ltd. +8615866703830 figo.gao@foxmail.com China 8491 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Shanghai Lollane Biological Technology Co.,Ltd. 55
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Chuzhou KeMail Chemical Technology Co., Ltd 55
Wuhan Sun-shine Bio-technology Corporation Limited 58
Jinan Carbotang Biotech Co.,Ltd. 58
BOC Sciences 58

View Latest Price from Elenbecestat(E2609) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Elenbecestat pictures 2026-09-10 Elenbecestat
1388651-30-6
 $64.00-263.00 99.95% 10g TargetMol Chemicals Inc.
Elenbecestat pictures 2026-07-27 Elenbecestat
1388651-30-6
 $64.00-263.00 99.95% 10g TargetMol Chemicals Inc.
  • Elenbecestat pictures
  • Elenbecestat
    1388651-30-6
  • $64.00-263.00
  • 99.95%
  • TargetMol Chemicals Inc.
  • Elenbecestat pictures
  • Elenbecestat
    1388651-30-6
  • $64.00-263.00
  • 99.95%
  • TargetMol Chemicals Inc.

Elenbecestat(E2609) Spectrum

Elenbecestat(E2609)(1388651-30-6)1HNMR

1388651-30-6 (Elenbecestat(E2609)) Related Search:

Elenbecestat(E2609) Elenbecestat LY2886721 N-[3-[(4aS,7aS)-2-Amino-5,7-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride NSC 55712
2-Pyridinecarboxamide, N-[3-[(3R,6R)-5-amino-3,6-dihydro-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl-

1of2

Elenbecestat(E2609) Elenbecestat(E26090 Alzheimer's disease,inhibit,Beta-secretase,E-2609,Inhibitor,Elenbecestat,E 2609,β-Secretase,BACE-1,BACE 2-Pyrazinecarboxamide, N-[3-[(4aS,5R,7aS)-2-amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)- N-(3-((4aS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide Elenbecestat, 10 mM in DMSO N-[3-[(4aS,5R,7aS)-2-Amino-5,7-dihydro-5-methyl-4H-furo[3,4-d][1,3]thiazin-7a(4aH)-yl]-4-fluorophenyl]-5-(difluoromethyl)-2-pyrazinecarboxamide (ACI) 1388651-30-6