3-(4-Methylpiperazin-1-yl)aniline
- CAS No.
- 148546-99-0
- Chemical Name:
- 3-(4-Methylpiperazin-1-yl)aniline
- Synonyms
- AKOS BB-8951;3-(4-Methylpiperazine) aniline;3-(4-Methypiperazin-1-yl)anilin;3-(4-METHYLPIPERAZIN-1-YL)ANILINE;3-(4-Methyl-1-piperazinyl)aniline;3-(4-methylazine-1-yl)benzeneamine;1-(3-Aminophenyl)-4-methylpiperazine;3-(4-Methyl-1-piperazinyl)aniline >3-(4-Methylpiperazin-1-yl)aniline 97%;3-(4-methylpiperazin-1-yl)benzenamine
- CBNumber:
- CB0487397
- Molecular Formula:
- C11H17N3
- Molecular Weight:
- 191.27
- MDL Number:
- MFCD08435857
- MOL File:
- 148546-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 98-99 |
|---|---|
| Boiling point | 353.1±37.0 °C(Predicted) |
| Density | 1.092±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.88±0.42(Predicted) |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C11H17N3/c1-13-5-7-14(8-6-13)11-4-2-3-10(12)9-11/h2-4,9H,5-8,12H2,1H3 |
| InChIKey | RJGHJWKQCJAJEP-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=CC(N2CCN(C)CC2)=C1 |
| CAS DataBase Reference | 148546-99-0 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 20/21/22-34 | |||||||||
| Safety Statements | 22-26-36/37/39-45 | |||||||||
| RIDADR | 2923 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-(4-Methylpiperazin-1-yl)aniline price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS004833 | 3-(4-methylpiperazin-1-yl)aniline AldrichCPR | 148546-99-0 | 100mg | $68.1 | 2023-06-20 | Buy |
| TCI Chemical | A2714 | 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | 148546-99-0 | 1g | $37 | 2026-04-30 | Buy |
| TCI Chemical | A2714 | 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | 148546-99-0 | 5g | $148 | 2026-04-30 | Buy |
| AstaTech | CL1607 | 3-(4-METHYLPIPERAZIN-1-YL)ANILINE 97% | 148546-99-0 | 5G | $77 | 2026-04-30 | Buy |
| AstaTech | CL1607 | 3-(4-METHYLPIPERAZIN-1-YL)ANILINE 97% | 148546-99-0 | 25G | $232 | 2026-04-30 | Buy |
3-(4-Methylpiperazin-1-yl)aniline Chemical Properties,Uses,Production
Uses
3-(4-methylpiperazin-1-yl)aniline is an amine derivative used in organic and pharmaceutical synthesis.
Chemical Properties
Yellow solid
Synthesis
148546-97-8
148546-99-0
Step - (ii): Synthesis of 3-(4-methylpiperazin-1-yl)aniline: A methanolic solution of 1-methyl-4-(3-nitrophenyl)piperazine (15 g, 78.5 mmol) was mixed with a methanolic solution of 10% Pd/C (3 g) under stirring. The reaction was carried out under inert atmosphere with slow stirring and under hydrogen atmosphere for 4 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford the target product 3-(4-methylpiperazin-1-yl)aniline (11 g, 87%) as a light yellow solid. Mass spectrum (electrospray ionization) m/z: 192 (M + 1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5221 - 5224
[2] Patent: WO2007/18941, 2007, A2. Location in patent: Page/Page column 96-97
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[4] RSC Advances, 2018, vol. 8, # 22, p. 11871 - 11885
[5] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 39; 40
3-(4-Methylpiperazin-1-yl)aniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
