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BI 3663

BI 3663 Structure
BI 3663 structure
CAS No.
2341740-84-7
Chemical Name:
BI 3663
Synonyms
BI 3663);BI-3663 (BI3663;4-[[4-[(2,3-Dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxybenzamide;N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide;Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy-
CBNumber:
CB74844551
Molecular Formula:
C44H42F3N7O12
Molecular Weight:
917.84
MDL Number:
MFCD31813809
MOL File:
2341740-84-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
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BI 3663 Properties

Density 1.456±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 300 mg/mL (326.85 mM; Need ultrasonic)
form Solid
pka 10.69±0.40(Predicted)
color Light yellow to yellow

BI 3663 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth RTD74084 BI-3663 2341740-84-7 1mg $813.53 2026-06-05 Buy
Biosynth RTD74084 BI-3663 2341740-84-7 5mg $2299.1 2026-06-05 Buy
Biosynth RTD74084 BI-3663 2341740-84-7 10mg $3678.5 2026-06-05 Buy
Biosynth RTD74084 BI-3663 2341740-84-7 25mg $6897.5 2026-06-05 Buy
Biosynth RTD74084 BI-3663 2341740-84-7 50mg $11035.5 2026-06-05 Buy
Product number Packaging Price Buy
RTD74084 1mg $813.53 Buy
RTD74084 5mg $2299.1 Buy
RTD74084 10mg $3678.5 Buy
RTD74084 25mg $6897.5 Buy
RTD74084 50mg $11035.5 Buy

BI 3663 Chemical Properties, Uses, Production

Uses

BI-3663 is a highly selective PTK2/FAK PROTAC (DC50=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker[1]. Anti-cancer activity[1].

IC 50

PTK2/FAK: 18 nM (IC50); Cereblon

References

[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826

BI 3663 Preparation Products And Raw materials

Raw materials

Preparation Products

BI 3663 Suppliers

Global Suppliers ( 19)
Supplier Tel Email Country ProdList Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 trendseenbio@gmail.com China 9067 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 4000862158 18117107507 vip@med-life.cn China 4999 58
Supplier Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58

View Latest Price from BI 3663 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BI-3663 pictures 2026-05-11 BI-3663
2341740-84-7
 $197.00-975.00 10g TargetMol Chemicals Inc.
  • BI-3663 pictures
  • BI-3663
    2341740-84-7
  • $197.00-975.00
  • TargetMol Chemicals Inc.

2341740-84-7 (BI 3663) Related Search:

Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG1-piperazine Pomalidomide-PEG2-butyl iodide Pomalidomide-C6-PEG3-butyl iodide Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide
BI 4464)

1of2

BI 3663) BI-3663 (BI3663 Benzamide, 4-[[4-[(2,3-dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxy- N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]-3-{2-[2-(2-{[3-methoxy-4-({4-[(3-oxo-2,3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide 4-[[4-[(2,3-Dihydro-3-oxo-1H-inden-4-yl)oxy]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-N-[2-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethyl]-3-methoxybenzamide 2341740-84-7