Thiophene-3-ethanol
- CAS No.
- 13781-67-4
- Chemical Name:
- Thiophene-3-ethanol
- Synonyms
- 2-(thiophen-3-yl)ethan-1-ol;3-THIOPHENEETHANOL;2-(thiophen-3-yl)ethanol;2-(3-ThienyL;THIOPHENE-3-ETHANOL;Thiophen-3-ylethanol;2-(3-THIENYL)ETHANOL;3-Thiopheneethanol 99%;Clopidogrel Impurity 51;3-THIOPHENEETHANOL 98+%
- CBNumber:
- CB0492744
- Molecular Formula:
- C6H8OS
- Molecular Weight:
- 128.19
- MDL Number:
- MFCD00009766
- MOL File:
- 13781-67-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 110-111 °C14 mm Hg(lit.) |
|---|---|
| Density | 1.144 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 199 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 14.92±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to yellow-brown |
| Specific Gravity | 1.144 |
| Water Solubility | Sparingly soluble in water(0.059 g/L at 25°C). |
| BRN | 107080 |
| InChI | 1S/C6H8OS/c7-3-1-6-2-4-8-5-6/h2,4-5,7H,1,3H2 |
| InChIKey | YYPNNBPPDFTQFX-UHFFFAOYSA-N |
| SMILES | OCCc1ccsc1 |
| LogP | 1.07 |
| CAS DataBase Reference | 13781-67-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Thiopheneethanol(13781-67-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210e-P280a-P370+P378a-P403+P235-P501a | |||||||||
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) | |||||||||
| Safety Statements | 23-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Thiophene-3-ethanol price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 228796 | 3-Thiopheneethanol 99% | 13781-67-4 | 5g | $89.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 228796 | 3-Thiopheneethanol 99% | 13781-67-4 | 25g | $427 | 2026-04-30 | Buy |
| TCI Chemical | T1475 | 3-Thiopheneethanol >97.0%(GC) | 13781-67-4 | 5g | $79 | 2026-04-30 | Buy |
| TCI Chemical | T1475 | 3-Thiopheneethanol >97.0%(GC) | 13781-67-4 | 25g | $272 | 2026-04-30 | Buy |
| AstaTech | 62948 | 3-(2-HYDROXYETHYL)THIOPHENE 97% | 13781-67-4 | 5G | $39 | 2026-04-30 | Buy |
Thiophene-3-ethanol Chemical Properties, Uses, Production
Chemical Properties
Clear colorless to yellowish-brown liquid
Uses
3-Thiopheneethanol is used as a reagent in the synthesis of pH-responsive near-IR emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery. 3-Thiopheneethanol is also used as a reagent in the preparation of potent respiratory syncytial virus RNA polymerase inhibitors.
Uses
3-Thiopheneethanol [3-(2-hydroxyethyl)thiophene] was used in the synthesis of various ether and ester derivatives such as 3-(2-(benzyloxy)ethyl)thiophene, 3-[2-((triphenylmethyl)oxy)ethyl]thiophene, 3-[2-((trimethylsilyl)oxy)ethyl]thiophene, 3-[2-((dimethyl-tert-butylsilyl)oxy)ethyl]thiophene, 3-(2-acetoxyethyl)thiophene and 3-(2-(benzoyloxy)ethyl)thiophene.
Synthesis
6964-21-2
13781-67-4
Step 2: Synthesis of 2-(thiophen-3-yl)ethanol 1. to LiAlH4 (4.56 g, 0.12 mol) was added tetrahydrofuran (200 mL) at 0 °C and the mixture was stirred. 2. Slowly add THF solution of 2-(thiophen-3-yl)acetic acid (14.2 g, 0.1 mol dissolved in 100 mL of THF) dropwise to the above mixture, keeping the temperature at 0 °C. 3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 2 hours. 4. EtOAc (200 mL) was slowly added to the reaction mixture followed by water (5 mL) to quench the reaction. 5. The resulting suspension was filtered through diatomaceous earth and the filtrate was dried with anhydrous sodium sulfate. 6. The dried filtrate was concentrated to dryness to give 2-(thiophen-3-yl)ethanol (12.44 g, yield: 99%). 7. The product was characterized by 1H NMR (MeOD, 400 MHz): δ 5.92-5.87 (m, 1H), 5.69-5.66 (m, 1H), 5.57 (s, 1H), 2.90 (d, J=14.0 Hz, 1H), 2.38 (d, J=14 Hz, 1H), 1.55-1.42 (m, 2H).
References
[1] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
[2] Synthesis, 2005, # 2, p. 267 - 271
[3] Synthesis (Germany), 2015, vol. 47, # 24, p. 3972 - 3982
[4] Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 256, p. 439 - 448
[5] Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575
Thiophene-3-ethanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Frontierchem Co.,Ltd. | 0532-88320311 15966837432 | sales@qdfrontierchem.com | China | 14 | 57 |
| Suzhou Xinrui Biotechnology Co., Ltd. | 13401437572 | xinruibiotech01@163.com | China | 2738 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Thiophene-3-ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Thiophene-3-ethanol
13781-67-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-06-30 | Thiophene-3-ethanol
13781-67-4
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | Thiophene-3-ethanol
13781-67-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Thiophene-3-ethanol
13781-67-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Thiophene-3-ethanol
13781-67-4
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Thiophene-3-ethanol
13781-67-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
