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FMOC-N-Methyl-L-alanine

FMOC-N-Methyl-L-alanine Structure
FMOC-N-Methyl-L-alanine structure
CAS No.
84000-07-7
Chemical Name:
FMOC-N-Methyl-L-alanine
Synonyms
FMOC-N-ME-ALA-OH;FMOC-N-ME-L-ALA-OH;FMOC-MEALA-OH;FMOC-L-MEALA-OH;Fmoc-L-N-Me-Ala-OH;Fmoc-N-Me-L-Alanine;Fmoc-N-Me-DL-Alanine;FMOC-N-ME-ALA 98.5+%;FMOC-N-METHYL-L-ALANINE;Fmoc-N-Me-Ala-OH
CBNumber:
CB0495149
Molecular Formula:
C19H19NO4
Molecular Weight:
325.36
MDL Number:
MFCD00153384
MOL File:
84000-07-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:47:00
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FMOC-N-Methyl-L-alanine Properties

Melting point ~150 °C
alpha -18.5 º (c=1,DMF)
Boiling point 514.9±29.0 °C(Predicted)
Density 1.262±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Soluble in water or 1% acetic acid
pka 3.92±0.10(Predicted)
form Solid
color White to Almost white
optical activity [α]20/D 18.5±1°, c = 1% in DMF
Water Solubility Slightly soluble in water.
BRN 4329998
Sequence Fmoc-N-Me-Ala-OH
Major Application peptide synthesis
InChI 1S/C19H19NO4/c1-12(18(21)22)20(2)19(23)24-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17H,11H2,1-2H3,(H,21,22)/t12-/m0/s1
InChIKey JOFHWKQIQLPZTC-LBPRGKRZSA-N
SMILES C[C@H](N(C)C(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference 84000-07-7(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HS Code  2924 29 70
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

FMOC-N-Methyl-L-alanine price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52138 Fmoc-N-Me-Ala-OH Novabiochem? 84000-07-7 1g $127 2026-04-30 Buy
Sigma-Aldrich 8.52138 Fmoc-N-Me-Ala-OH Novabiochem? 84000-07-7 5G $492 2026-04-30 Buy
Sigma-Aldrich 47594 Fmoc-N-Me-Ala-OH ≥97.0% (sum of enantiomers, HPLC) 84000-07-7 1G $114 2026-04-30 Buy
TCI Chemical F1164 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine 84000-07-7 5G $50 2026-04-30 Buy
Usbiological 276962 Fmoc-N-methyl-L-alanine Asreported 84000-07-7 5g $382 2026-06-03 Buy
Product number Packaging Price Buy
8.52138 1g $127 Buy
8.52138 5G $492 Buy
47594 1G $114 Buy
F1164 5G $50 Buy
276962 5g $382 Buy

FMOC-N-Methyl-L-alanine Chemical Properties,Uses,Production

Chemical Properties

White to off white powder

Uses

It is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. Also used in N-methyl amino acids for peptide synthesis.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

3-Oxazolidinecarboxylic acid, 4-methyl-5-oxo-, 9H-fluoren-9-ylmethyl ester, (4S)-

83999-95-5

FMOC-N-Methyl-L-alanine

84000-07-7

The general procedure for the synthesis of Fmoc-N-methyl-L-alanine from the compound (CAS: 83999-95-5) was as follows: paraformaldehyde (4.0 g, 133 mmol) and p-toluenesulfonic acid (0.5 g, 13.3 mmol) were added to a suspension of Fmoc-L-alanine (6.2 g, 19.9 mmol) in toluene (400 mL). The mixture was refluxed for 30 min to remove azeotropic water. The solution was cooled, washed with 1 M aqueous NaHCO3 (2 x 100 mL) and dried with Na2SO4. Subsequently, the solution was concentrated in vacuum to give a white solid. The above oxazolidinone was dissolved in chloroform (75 mL) and trifluoroacetic acid (75 mL) and triethylsilane (7.2 mL, 44.8 mmol) were added. The reaction mixture was stirred at room temperature for 10 hours and then concentrated under vacuum. The resulting oily substance was dissolved in dichloromethane and the concentration was repeated three times. After standing, the oily substance crystallized. The crystals were redissolved in ether and concentrated. Finally, the collected white solid was washed with 5% ether/hexane and dried to give the product (6.1 g, 94% yield).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 30, p. 3872 - 3875
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Tetrahedron Letters, 2014, vol. 55, # 44, p. 6109 - 6112

FMOC-N-Methyl-L-alanine Preparation Products And Raw materials

Raw materials

3-Oxazolidinecarboxylic acid, 4-methyl-5-oxo-, 9H-fluoren-9-ylmethyl ester, (4S)- Trifluoroacetic acid Chloroform Triethylsilane

Preparation Products

FMOC-N-Methyl-L-alanine Suppliers

Global( 266)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alabiochem Tech.Co., Ltd. 512-58900862 400-0707518 sales@alabiochem.com China 988 59
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alabiochem Tech.Co., Ltd. 59
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Jia Xing Isenchem Co.,Ltd 66

View Lastest Price from FMOC-N-Methyl-L-alanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-N-Me-Ala-OH pictures 2026-09-10 Fmoc-L-N-Me-Ala-OH
84000-07-7
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-N-Me-Ala-OH pictures 2026-05-11 Fmoc-N-Me-Ala-OH
84000-07-7
 $29.00 99.70% 10g TargetMol Chemicals Inc.
FMOC-N-Methyl-L-alanine pictures 2021-08-12 FMOC-N-Methyl-L-alanine
84000-07-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

FMOC-N-Methyl-L-alanine Spectrum

FMOC-N-Methyl-L-alanine(84000-07-7)1HNMR

84000-07-7(FMOC-N-Methyl-L-alanine)Related Search:

N-Methyl-L-alanine FMOC-Ala-OH Methyl salicylate Fmoc-Lys(Boc)-OH Methyl acrylate
Methanol Kresoxim-methyl DL-Alanine D-Alanine β-Alanine
L-Fmoc-Aspartic acid alpha-tert-butyl ester 9-Fluorenylmethyl chloroformate EC 2.6.1.2 FMOC-b-Ala-OH L-Alanine
Phenprobamate Fmoc-Phe-OH Fmoc-Asp(OtBu)-OH

1of4

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoic acid Fmoc-N-Me-DL-Alanine Fmoc-N-methyl-L-alanine≥ 99% (HPLC) (9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Ala-OH N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)propanoic acid N-FMoc-N-Methyl-L-alanine, 95% Fmoc-N-Me-L-Alanine FMOC-L-MEALA-OH FMOC-N-ALPHA-METHYL-L-ALANINE FMOC-N-METHYL-L-ALANINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE N-ALPHA-FMOC-N-ALPHA-METHYL-L-ALANINE Nα-(9-Fluorenylmethyloxycarbonyl)-Nα-methyl-L-alanine ,98% FMOC-N-ME-ALA 98.5+% Fmoc-N-Me-Ala-OH Fmoc-N-methyl-L-Alanine L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl- FMOC-N-Methyl-L-alanine USP/EP/BP Fmoc-L-N-Me-Ala-OH FMoc-N-α-Methyl-L-alanine N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine Fmoc-N-Me-Ala-OH, 10 mM in DMSO Fmoc-N-Me-Ala-OH (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid - [F73034] N-Fmoc-N-methyl-L-alanine FMOC-MEALA-OH FMOC-N-ME-ALA-OH FMOC-N-ME-L-ALA-OH 84000-07-7 42117-65-2 C19H19NO4 Peptide Synthesis N-Methyl Amino Acids Specialty Synthesis Unnatural Amino Acid Derivatives Amino Acids Alanine [Ala, A] N-Methyl Amino Acids Fmoc-Amino acid series