FMOC-N-Methyl-L-alanine
- CAS No.
- 84000-07-7
- Chemical Name:
- FMOC-N-Methyl-L-alanine
- Synonyms
- FMOC-MEALA-OH;FMOC-L-MEALA-OH;FMOC-N-ME-ALA-OH;FMOC-N-ME-L-ALA-OH;Fmoc-L-N-Me-Ala-OH;Fmoc-N-Me-L-Alanine;Fmoc-N-Me-DL-Alanine;FMOC-N-ME-ALA 98.5+%;FMOC-N-METHYL-L-ALANINE;Fmoc-N-Me-Ala-OH
- CBNumber:
- CB0495149
- Molecular Formula:
- C19H19NO4
- Molecular Weight:
- 325.36
- MDL Number:
- MFCD00153384
- MOL File:
- 84000-07-7.mol
- MSDS File:
- SDS
| Melting point | ~150 °C |
|---|---|
| alpha | -18.5 º (c=1,DMF) |
| Boiling point | 514.9±29.0 °C(Predicted) |
| Density | 1.262±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in water or 1% acetic acid |
| pka | 3.92±0.10(Predicted) |
| form | Solid |
| color | White to Almost white |
| optical activity | [α]20/D 18.5±1°, c = 1% in DMF |
| Water Solubility | Slightly soluble in water. |
| BRN | 4329998 |
| Sequence | Fmoc-N-Me-Ala-OH |
| InChIKey | JOFHWKQIQLPZTC-LBPRGKRZSA-N |
| CAS DataBase Reference | 84000-07-7(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WGK Germany | 3 | |||||||||
| HS Code | 2924 29 70 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
FMOC-N-Methyl-L-alanine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52138 | Fmoc-N-Me-Ala-OH Novabiochem? | 84000-07-7 | 1g | $119 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.52138 | Fmoc-N-Me-Ala-OH Novabiochem? | 84000-07-7 | 5G | $462 | 2025-07-31 | Buy |
| Sigma-Aldrich | 47594 | Fmoc-N-Me-Ala-OH ≥97.0% (sum of enantiomers, HPLC) | 84000-07-7 | 1G | $107 | 2025-07-31 | Buy |
| TCI Chemical | F1164 | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine | 84000-07-7 | 5G | $55 | 2025-07-31 | Buy |
| TRC | F679778 | Fmoc-N-methyl-L-Alanine | 84000-07-7 | 1g | $75 | 2021-12-16 | Buy |
FMOC-N-Methyl-L-alanine Chemical Properties,Uses,Production
Chemical Properties
White to off white powder
Uses
It is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. Also used in N-methyl amino acids for peptide synthesis.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
83999-95-5
84000-07-7
The general procedure for the synthesis of Fmoc-N-methyl-L-alanine from the compound (CAS: 83999-95-5) was as follows: paraformaldehyde (4.0 g, 133 mmol) and p-toluenesulfonic acid (0.5 g, 13.3 mmol) were added to a suspension of Fmoc-L-alanine (6.2 g, 19.9 mmol) in toluene (400 mL). The mixture was refluxed for 30 min to remove azeotropic water. The solution was cooled, washed with 1 M aqueous NaHCO3 (2 x 100 mL) and dried with Na2SO4. Subsequently, the solution was concentrated in vacuum to give a white solid. The above oxazolidinone was dissolved in chloroform (75 mL) and trifluoroacetic acid (75 mL) and triethylsilane (7.2 mL, 44.8 mmol) were added. The reaction mixture was stirred at room temperature for 10 hours and then concentrated under vacuum. The resulting oily substance was dissolved in dichloromethane and the concentration was repeated three times. After standing, the oily substance crystallized. The crystals were redissolved in ether and concentrated. Finally, the collected white solid was washed with 5% ether/hexane and dried to give the product (6.1 g, 94% yield).
References
[1] Tetrahedron Letters, 2011, vol. 52, # 30, p. 3872 - 3875
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Tetrahedron Letters, 2014, vol. 55, # 44, p. 6109 - 6112
FMOC-N-Methyl-L-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 | cynthia@enlaibio.com | China | 1100 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Sichuan Jiaying Lai Technology Co.,LTD | 18716376478 | ycling@enlaibio.com | CHINA | 302 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from FMOC-N-Methyl-L-alanine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-05 | Fmoc-L-N-Me-Ala-OH
84000-07-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-06-12 | Fmoc-N-Me-Ala-OH
84000-07-7
|
US $29.00 / mL | 99.45% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-08-12 | FMOC-N-Methyl-L-alanine
84000-07-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Fmoc-L-N-Me-Ala-OH
84000-07-7
- US $0.00-0.00 / kg
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Fmoc-N-Me-Ala-OH
84000-07-7
- US $29.00 / mL
- 99.45%
- TargetMol Chemicals Inc.
-
- FMOC-N-Methyl-L-alanine
84000-07-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd