2-Hydroxy-4-(trifluoromethyl)quinoline
- CAS No.
- 25199-84-2
- Chemical Name:
- 2-Hydroxy-4-(trifluoromethyl)quinoline
- Synonyms
- BUTTPARK 33\04-80;4-(Trifluoromethyl)quinolin-2-ol;4-Trifluoromethyl-1H-quinolin-2-one;4-trifluoroMethyl-2(1H)-quinolinone;4-(trifluoromethyl)quinolin-2(1H)-one;2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE;4--(TrifluoroMethyl)quinoline-2(H)-one;2-hydroxy-4-(trifluoroMethyl)quinqline;4-Trifluoromethyl-2(1H)-quinolinone,97%;2(1H)-Quinolinone, 4-(trifluoromethyl)-
- CBNumber:
- CB0496696
- Molecular Formula:
- C10H6F3NO
- Molecular Weight:
- 213.16
- MDL Number:
- MFCD03407380
- MOL File:
- 25199-84-2.mol
- MSDS File:
- SDS
| Melting point | >240°C |
|---|---|
| Boiling point | 284 ºC |
| Density | 1.391 |
| Flash point | 126 ºC |
| storage temp. | Sealed in dry,Room Temperature |
| form | Solid |
| color | White |
| InChI | InChI=1S/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15) |
| InChIKey | UUROBWTVZZNDFD-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C(C(F)(F)F)=CC1=O |
| CAS DataBase Reference | 25199-84-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
2-Hydroxy-4-(trifluoromethyl)quinoline price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 67050 | 4-TRIFLUOROMETHYL-2(1H)-QUINOLINONE 97% | 25199-84-2 | 0.25G | $56 | 2026-04-30 | Buy |
| AstaTech | 67050 | 4-TRIFLUOROMETHYL-2(1H)-QUINOLINONE 97% | 25199-84-2 | 1G | $123 | 2026-04-30 | Buy |
| AstaTech | 67050 | 4-TRIFLUOROMETHYL-2(1H)-QUINOLINONE 97% | 25199-84-2 | 5G | $389 | 2026-04-30 | Buy |
| Matrix Scientific | 074152 | 2-Hydroxy-4-(trifluoromethyl)quinoline | 25199-84-2 | 1.00g | $416 | 2026-05-18 | Buy |
| Matrix Scientific | 074152 | 2-Hydroxy-4-(trifluoromethyl)quinoline | 25199-84-2 | 5.00g | $1197 | 2026-05-18 | Buy |
2-Hydroxy-4-(trifluoromethyl)quinoline Chemical Properties, Uses, Production
Uses
4-Trifluoromethyl-2-hydroxyquinoline has a wide range of applications in the pharmaceutical field and can be used as an intermediate for antibacterial, antiviral, anti-inflammatory and antitumor drugs.
Chemical Properties
White solid
Synthesis
4-Trifluoromethylquinolin-2(1H)-one was prepared by reacting aniline and ethyl-4,4,4-trifluoroacetoacetate stirred in toluene.
Experimental Procedure: In a 1 L round flask fitted with a reflux condenser a mixture of 25.60 g aniline, 50.0 g ethyl-4,4,4-trifluoroacetoacetate 300 ml toluene was heated to reflux in an oil bath at 130 °C. After 20 min 3 ml water was added and the mixture was heated at reflux for another 24 h. the reaction mixture was cooled to room temperature and concentrated under reduced pressure. A round flask with 200 mL H2SO4 was heated to 80°C and the crude oil from the step before was added in portions to the H2SO4 keeping the internal temperature below 90°C, total addition time was approximately 40 min. After addition was complete, the mixture was stirred at 80°C for 1 h, cooled and poured onto 400 g crushed ice. The resulting solids were filtered, washed with water, and dried under vacuum at 40°C to give 33.0 g (50%) product (2-Hydroxy-4-(trifluoromethyl)quinoline) as a colorless solid.
References
[1] Synthesis, 2003, # 13, p. 2005 - 2010
[2] Patent: WO2018/165385, 2018, A1. Location in patent: Paragraph 00362
[3] European Journal of Organic Chemistry, 2003, # 11, p. 2115 - 2121
[4] Patent: US2012/214803, 2012, A1. Location in patent: Page/Page column 172
[5] Patent: US2008/275057, 2008, A1. Location in patent: Page/Page column 86
2-Hydroxy-4-(trifluoromethyl)quinoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhouhongxiong | 18051745768 | Suzhouhongxiong@163.com | China | 60 | 58 |
| Jointpharma Technology Co.Ltd | 021-61150629 15921749159 | 0235@jointpharma.cn | China | 362 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 2-Hydroxy-4-(trifluoromethyl)quinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
25199-84-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-07-06 | 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
25199-84-2
|
$1.00 | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
25199-84-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
25199-84-2
- $1.00
- 98%
- Career Henan Chemical Co
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