3-Fluoro-5-nitrobenzoic acid
- CAS No.
- 14027-75-9
- Chemical Name:
- 3-Fluoro-5-nitrobenzoic acid
- Synonyms
- 3-Fluoro-5-NitrobenzoicAci;3-Fluoro-5-nitrobenzoic acid;3-Fluoro-5-nitrobenzoicacid,97%;Benzoic acid, 3-fluoro-5-nitro-;3-Fluoro-5-nitrobenzoic acid ,98%;3-FLUORO-5-NITROBENZOIC ACID ISO 9001：2015 REACH
- CBNumber:
- CB0683670
- Molecular Formula:
- C7H4FNO4
- Molecular Weight:
- 185.11
- MDL Number:
- MFCD05864360
- MOL File:
- 14027-75-9.mol
- MSDS File:
- SDS
| Melting point | 125°C |
|---|---|
| Boiling point | 341.2±27.0 °C(Predicted) |
| Density | 1.568±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.14±0.10(Predicted) |
| form | Solid |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C7H4FNO4/c8-5-1-4(7(10)11)2-6(3-5)9(12)13/h1-3H,(H,10,11) |
| InChIKey | VIPUIECMSDQUIK-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC([N+]([O-])=O)=CC(F)=C1 |
| CAS DataBase Reference | 14027-75-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
3-Fluoro-5-nitrobenzoic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC48725 | 3-Fluoro-5-nitrobenzoic acid >98% | 14027-75-9 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC48725 | 3-Fluoro-5-nitrobenzoic acid >98% | 14027-75-9 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC48725 | 3-Fluoro-5-nitrobenzoic acid >98% | 14027-75-9 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | PC48725 | 3-Fluoro-5-nitrobenzoic acid >98% | 14027-75-9 | 25g | $105 | 2026-06-04 | Buy |
| Apolloscientific | PC48725 | 3-Fluoro-5-nitrobenzoic acid >98% | 14027-75-9 | 100g | $395 | 2026-06-04 | Buy |
3-Fluoro-5-nitrobenzoic acid Chemical Properties, Uses, Production
Uses
3-fluoro-5-nitrobenzoic acid is an industrial chemical with a variety of uses. It is used as an intermediate in the production of other chemicals and pharmaceuticals. 3-Fluoro-5-nitrobenzoic acid can be activated to form the corresponding sodium salt, which has been used as a reagent for organic synthesis. This chemical can also be used to produce n-oxides, such as phenoxides and nitrophenols. 3-Fluoro-5-nitrobenzoic acid is also used to synthesize industrial chemicals, including chlorides and benzene derivatives.
Synthesis
618-84-8
95-50-1
14027-75-9
An acetonitrile (50 mL) slurry of nitrosonium tetrafluoroborate (3.53 g, 30.2 mM) was cooled in an ice bath under argon protection and stirred vigorously. Subsequently, 3-amino-5-nitrobenzoic acid (5.0 g, 27.5 mM) was added in three batches. When the addition was complete, the reaction mixture was gradually warmed to room temperature and stirred continuously for 48 hours. Upon completion of the reaction, 1,2-dichlorobenzene (50 mL) was added and the acetonitrile was removed by distillation under reduced pressure. Subsequently, the mixture was heated to 170°C and maintained for 30 minutes until the gas stopped escaping. After cooling, the reaction mixture was poured into dichloromethane (200 mL) and extracted with NaHCO3 solution. The aqueous phase was backwashed with dichloromethane, acidified with 2 M hydrochloric acid, and then the organic phase was extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed with brine and dried with MgSO4. The crude product was purified by silica gel column chromatography using a gradient elution from dichloromethane/acetic acid (99:1) to dichloromethane/isopropanol/acetic acid (80:20:1), resulting in 3-fluoro-5-nitrobenzoic acid (3.26 g, 64% yield). The NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 8.14 (dm, 1H); δ 8.37 (dt, 1H); δ 8.46 (m, 1H).
References
[1] Patent: US5478820, 1995, A
3-Fluoro-5-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 3-Fluoro-5-nitrobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2021-10-21 | 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
|
$10.00 | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2021-08-12 | 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
- $1.00-100.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 3-FLUORO-5-NITROBENZOIC ACID
14027-75-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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