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ChemicalBook >> CAS DataBase List >>N-4-Boc-2-piperazinecarboxylic acid

N-4-Boc-2-piperazinecarboxylic acid

N-4-Boc-2-piperazinecarboxylic acid Structure
N-4-Boc-2-piperazinecarboxylic acid structure
CAS No.
128019-59-0
Chemical Name:
N-4-Boc-2-piperazinecarboxylic acid
Synonyms
(R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;4-BOC-;(4-N-BOC)PIPERAZINE(2R) COOH;4-BOCpiperazin-2-carboxylic acid;4-Boc-2-piperazinecarboxylic acid;4-N-Boc-2-piperazinecarboxylic acid;N4-Boc-piperazine-2-carboxylic acid;N-4-BOC-2-PIPERAZINECARBOXYLIC ACID;4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-4-Boc-piperazine-2-carboxylid acid
CBNumber:
CB0693082
Molecular Formula:
C10H18N2O4
Molecular Weight:
230.26
MDL Number:
MFCD01076218
MOL File:
128019-59-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:50:48
Product description Number Pack Size Price
4-Boc-piperazine-2-carboxylic acid 676365 1g $83.1
N-4-Boc-2-piperazine carboxylic acid Asreported 287262 5g $382
N-4-Boc-2-piperazine carboxylic acid Asreported 287262 10g $542
N-4-Boc-2-piperazine carboxylic acid Asreported 287262 25g $835
N-4-Boc-2-piperazine carboxylic acid Asreported 287262 50g $1204
More product size
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N-4-Boc-2-piperazinecarboxylic acid Properties

Melting point 231-239 °C
Boiling point 371.8±37.0 °C(Predicted)
Density 1.193±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 2.20±0.20(Predicted)
form powder or crystals
Appearance White to off-white Solid
Water Solubility Slightly soluble in water.
InChI 1S/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)
InChIKey YRYAXQJXMBETAT-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)N1CCNC(C1)C(O)=O
CAS DataBase Reference 128019-59-0(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38-43-36
Safety Statements  26-36/37/39-36/37
WGK Germany  3
HazardClass  IRRITANT
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Sens. 1
NFPA 704
0
2 0

N-4-Boc-2-piperazinecarboxylic acid price More Price(92)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 676365 4-Boc-piperazine-2-carboxylic acid 128019-59-0 1g $83.1 2026-04-30 Buy
Usbiological 287262 N-4-Boc-2-piperazine carboxylic acid Asreported 128019-59-0 5g $382 2026-06-03 Buy
Usbiological 287262 N-4-Boc-2-piperazine carboxylic acid Asreported 128019-59-0 10g $542 2026-06-03 Buy
Usbiological 287262 N-4-Boc-2-piperazine carboxylic acid Asreported 128019-59-0 25g $835 2026-06-03 Buy
Usbiological 287262 N-4-Boc-2-piperazine carboxylic acid Asreported 128019-59-0 50g $1204 2026-06-03 Buy
Product number Packaging Price Buy
676365 1g $83.1 Buy
287262 5g $382 Buy
287262 10g $542 Buy
287262 25g $835 Buy
287262 50g $1204 Buy

N-4-Boc-2-piperazinecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

As active pharmaceutical drugs and intermediates possess different biological activities.

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

Piperazine-2-carboxylic acid dihydrochloride

3022-15-9

N-4-Boc-2-piperazinecarboxylic acid

128019-59-0

General procedure for the synthesis of 4-Boc-piperazine-2-carboxylic acid from di-tert-butyl dicarbonate and piperazine-2-carboxylic acid dihydrochloride: sodium bicarbonate (3.1 g, 36.9 mmol) was added to a stirred suspension of piperazine-2-carboxylic acid (5 g, 24.6 mmol) in 1,4-dioxane and water (1:1, 100 mL) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.6 mL, 24.6 mmol) was added slowly at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was diluted with water (50 mL) and extracted with ether (2 x 100 mL). The aqueous phase was acidified with 2N hydrochloric acid solution and then extracted with n-butanol. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound 4-Boc-piperazine-2-carboxylic acid (5 g, 88% yield) as a white solid.1H-NMR (500 MHz, DMSO-d6): δ 10.18 (broad peak, 1H), 4.08 (broad peak, 1H), 3.81-3.71 (multiple peaks, 2H), 3.63 (triple peak, J=6.5Hz, 1H), 3.17-3.15 (multiple peaks, 2H), 2.91-2.86 (multiple peaks, 1H), 1.36 (single peak, 9H), 1.31-1.26 (multiple peaks, 0.5H), 0.87-0.84 (multiple peaks, 0.5H). lcms (esi): m/z 229.0 [M+H]+.

References

[1] Patent: WO2018/26782, 2018, A1. Location in patent: Page/Page column 30-31
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 3, p. 369 - 380

N-4-Boc-2-piperazinecarboxylic acid Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Piperazine-2-carboxylic acid dihydrochloride Water 1,4-Dioxane Sodium bicarbonate

Preparation Products

METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE

N-4-Boc-2-piperazinecarboxylic acid Suppliers

Global( 245)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9976 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52704 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
SIMAGCHEM CORP 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from N-4-Boc-2-piperazinecarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-4-Boc-2-piperazinecarboxylic acid pictures 2021-08-12 N-4-Boc-2-piperazinecarboxylic acid
128019-59-0
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
N-4-Boc-2-piperazinecarboxylic acid pictures 2019-07-06 N-4-Boc-2-piperazinecarboxylic acid
128019-59-0
 $1.00 1KG 99% 1ton Career Henan Chemical Co

N-4-Boc-2-piperazinecarboxylic acid Spectrum

N-4-Boc-2-piperazinecarboxylic acid(128019-59-0)1HNMRN-4-Boc-2-piperazinecarboxylic acid(128019-59-0)1HNMR

128019-59-0(N-4-Boc-2-piperazinecarboxylic acid)Related Search:

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1of4

1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (R)-4-Boc-piperazine-2-carboxylid acid (^+)-4-Boc-piperazine-2-carboxylic acid hydrate, 95% 4-Boc-2-piperazinecarboxylic acid 4-BOCpiperazin-2-carboxylic acid 4-BOC- 4-Boc-piperazine-2-carboxylic acid,1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester N4-Boc-piperazine-2-carboxylic acid 98% N4-Boc-piperazine-2-carboxylic acid 4-N-Boc-2-piperazinecarboxylic acid (^+)-4-Boc-piperazine-2-carboxylicacidhydrate,95% 1,3-Piperazinedicarboxylic acid 1-(tert-butyl) ester 4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID 4-(TERT-BUTOXYLCARBONYL)-PIPERAZINE-2-CARBOXYLIC ACID 4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (4-N-BOC)PIPERAZINE(2R) COOH 1,3-PIPERAZINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER (R)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID N-4-BOC-2-PIPERAZINECARBOXYLIC ACID (R)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (+/-)-4-Boc-piperazine-2-carboxylic acid hydrate (R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 128019-59-0 C10H18N2O4 C10H18N2O4H2O Heterocyclic Building Blocks Building Blocks C10 Chemical Synthesis pharmacetical Piperaizine Piperazines CR-Y-19