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N-4-Boc-2-piperazinecarboxylic acid

N-4-Boc-2-piperazinecarboxylic acid structure

CAS No.: 128019-59-0

Chemical Name:: N-4-Boc-2-piperazinecarboxylic acid

Synonyms: (R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;4-BOC-;(4-N-BOC)PIPERAZINE(2R) COOH;4-BOCpiperazin-2-carboxylic acid;4-Boc-2-piperazinecarboxylic acid;4-N-Boc-2-piperazinecarboxylic acid;N4-Boc-piperazine-2-carboxylic acid;N-4-BOC-2-PIPERAZINECARBOXYLIC ACID;4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-4-Boc-piperazine-2-carboxylid acid

CBNumber:: CB0693082

Molecular Formula:: C10H18N2O4

Molecular Weight:: 230.26

MDL Number:: MFCD01076218

MOL File:: 128019-59-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:50:48

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N-4-Boc-2-piperazinecarboxylic acid Properties

Melting point	231-239 °C
Boiling point	371.8±37.0 °C(Predicted)
Density	1.193±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	2.20±0.20(Predicted)
form	powder or crystals
Appearance	White to off-white Solid
Water Solubility	Slightly soluble in water.
InChI	1S/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-7(6-12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)
InChIKey	YRYAXQJXMBETAT-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCNC(C1)C(O)=O
CAS DataBase Reference	128019-59-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H319

Precautionary statements

P280-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Risk Statements

36/37/38-43-36

Safety Statements

26-36/37/39-36/37

WGK Germany

HazardClass

IRRITANT

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Sens. 1

NFPA 704

	0
2		0

N-4-Boc-2-piperazinecarboxylic acid price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	676365	4-Boc-piperazine-2-carboxylic acid	128019-59-0	1g	$83.1	2026-04-30	Buy
Usbiological	287262	N-4-Boc-2-piperazine carboxylic acid Asreported	128019-59-0	5g	$382	2026-06-03	Buy
Usbiological	287262	N-4-Boc-2-piperazine carboxylic acid Asreported	128019-59-0	10g	$542	2026-06-03	Buy
Usbiological	287262	N-4-Boc-2-piperazine carboxylic acid Asreported	128019-59-0	25g	$835	2026-06-03	Buy
Usbiological	287262	N-4-Boc-2-piperazine carboxylic acid Asreported	128019-59-0	50g	$1204	2026-06-03	Buy

Product number	Packaging	Price	Buy
676365	1g	$83.1	Buy
287262	5g	$382	Buy
287262	10g	$542	Buy
287262	25g	$835	Buy
287262	50g	$1204	Buy

N-4-Boc-2-piperazinecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

As active pharmaceutical drugs and intermediates possess different biological activities.

Synthesis

24424-99-5

Piperazine-2-carboxylic acid dihydrochloride

3022-15-9

128019-59-0

General procedure for the synthesis of 4-Boc-piperazine-2-carboxylic acid from di-tert-butyl dicarbonate and piperazine-2-carboxylic acid dihydrochloride: sodium bicarbonate (3.1 g, 36.9 mmol) was added to a stirred suspension of piperazine-2-carboxylic acid (5 g, 24.6 mmol) in 1,4-dioxane and water (1:1, 100 mL) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.6 mL, 24.6 mmol) was added slowly at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was diluted with water (50 mL) and extracted with ether (2 x 100 mL). The aqueous phase was acidified with 2N hydrochloric acid solution and then extracted with n-butanol. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target compound 4-Boc-piperazine-2-carboxylic acid (5 g, 88% yield) as a white solid.1H-NMR (500 MHz, DMSO-d6): δ 10.18 (broad peak, 1H), 4.08 (broad peak, 1H), 3.81-3.71 (multiple peaks, 2H), 3.63 (triple peak, J=6.5Hz, 1H), 3.17-3.15 (multiple peaks, 2H), 2.91-2.86 (multiple peaks, 1H), 1.36 (single peak, 9H), 1.31-1.26 (multiple peaks, 0.5H), 0.87-0.84 (multiple peaks, 0.5H). lcms (esi): m/z 229.0 [M+H]+.

References

[1] Patent: WO2018/26782, 2018, A1. Location in patent: Page/Page column 30-31
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 3, p. 369 - 380

N-4-Boc-2-piperazinecarboxylic acid Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Piperazine-2-carboxylic acid dihydrochloride Water 1,4-Dioxane Sodium bicarbonate

Preparation Products

Methyl 4-Boc-piperazine-2-carboxylate

N-4-Boc-2-piperazinecarboxylic acid Suppliers

Global( 244)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Sichuan Guanghan Bio-Tech Co., Ltd	+86-28-86127071	info@sino-produce.com	China	400	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Sichuan Guanghan Bio-Tech Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59

View Lastest Price from N-4-Boc-2-piperazinecarboxylic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-12	N-4-Boc-2-piperazinecarboxylic acid 128019-59-0	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	N-4-Boc-2-piperazinecarboxylic acid 128019-59-0	$1.00	1KG	99%	1ton	Career Henan Chemical Co

N-4-Boc-2-piperazinecarboxylic acid
128019-59-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-4-Boc-2-piperazinecarboxylic acid
128019-59-0
$1.00
99%
Career Henan Chemical Co

N-4-Boc-2-piperazinecarboxylic acid Spectrum

N-4-Boc-2-piperazinecarboxylic acid(128019-59-0)¹HNMR N-4-Boc-2-piperazinecarboxylic acid(128019-59-0)¹HNMR

128019-59-0(N-4-Boc-2-piperazinecarboxylic acid)Related Search:

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1of4

1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester (R)-4-Boc-piperazine-2-carboxylid acid (^+)-4-Boc-piperazine-2-carboxylic acid hydrate, 95% 4-Boc-2-piperazinecarboxylic acid 4-BOCpiperazin-2-carboxylic acid 4-BOC- 4-Boc-piperazine-2-carboxylic acid,1-Boc-piperazine-3-carboxylic acid, 4-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid, Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester N4-Boc-piperazine-2-carboxylic acid 98% N4-Boc-piperazine-2-carboxylic acid 4-N-Boc-2-piperazinecarboxylic acid (^+)-4-Boc-piperazine-2-carboxylicacidhydrate,95% 1,3-Piperazinedicarboxylic acid 1-(tert-butyl) ester 4-[(2-methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxylic acid 4-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID 4-(TERT-BUTOXYLCARBONYL)-PIPERAZINE-2-CARBOXYLIC ACID 4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (4-N-BOC)PIPERAZINE(2R) COOH 1,3-PIPERAZINEDICARBOXYLIC ACID, 1-(1,1-DIMETHYLETHYL) ESTER (R)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-4-BOC-PIPERAZINE-2-CARBOXYLIC ACID N-4-BOC-2-PIPERAZINECARBOXYLIC ACID (R)-PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (+/-)-4-Boc-piperazine-2-carboxylic acid hydrate (R)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 128019-59-0 C10H18N2O4 C10H18N2O4H2O Heterocyclic Building Blocks Building Blocks C10 Chemical Synthesis pharmacetical Piperaizine Piperazines CR-Y-19