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Methyl 4-Boc-piperazine-2-carboxylate

Methyl 4-Boc-piperazine-2-carboxylate Structure
Methyl 4-Boc-piperazine-2-carboxylate structure
CAS No.
129799-08-2
Chemical Name:
Methyl 4-Boc-piperazine-2-carboxylate
Synonyms
Methyl 4-Boc-piperazine-2-carboxylate;METHYL 4N-BOC-PIPERAZINE-2-CARBOXYLATE;Methyl (±)-4-Boc-piperazine-2-carboxylate;1-Boc-piperazine-3-carboxylic acid Methyl ester;N-4-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER;4N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;1-N-Boc-piperazine-3-carboxylic acid methyl ester;4-Boc-2-Piperazinecarboxylic acid methyl ester;1-TERT-BUTYL-3-METHYL-PIPERAZINE-1,3-DICARBOXYLATE;4-N-BOC-PIPERAZINE-2-CRBOXYLIC ACID METHYL ESTER-HCl
CBNumber:
CB6154983
Molecular Formula:
C11H20N2O4
Molecular Weight:
244.29
MDL Number:
MFCD01632465
MOL File:
129799-08-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:57
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Methyl 4-Boc-piperazine-2-carboxylate Properties

Melting point 159-160 °C
Boiling point 321.3±37.0 °C(Predicted)
Density 1.118±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Soluble in dimethyl sulfoxide.
pka 6.45±0.40(Predicted)
Appearance White to light yellow Solid-Liquid Mixture
InChI InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-8(7-13)9(14)16-4/h8,12H,5-7H2,1-4H3
InChIKey QUKAHFCVKNRRBU-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCNC(C(OC)=O)C1
CAS DataBase Reference 129799-08-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Risk Statements  36/37/38
Safety Statements  26-36/37/39
HS Code  2933599590
NFPA 704
1
2 0

Methyl 4-Boc-piperazine-2-carboxylate price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 66879 N-4-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER 98% 129799-08-2 1G $36 2026-04-30 Buy
AstaTech 66879 N-4-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER 98% 129799-08-2 5G $85 2026-04-30 Buy
AstaTech 66879 N-4-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER 98% 129799-08-2 25G $280 2026-04-30 Buy
Biosynth FB140578 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 129799-08-2 10g $256.9 2026-06-04 Buy
Biosynth FB140578 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate 129799-08-2 25g $515.25 2026-06-04 Buy
Product number Packaging Price Buy
66879 1G $36 Buy
66879 5G $85 Buy
66879 25G $280 Buy
FB140578 10g $256.9 Buy
FB140578 25g $515.25 Buy

Methyl 4-Boc-piperazine-2-carboxylate Chemical Properties,Uses,Production

Uses

It is used as pharmaceutical intermediate.

Synthesis

METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE

126937-42-6

METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE

129799-08-2

Step 3: 10% Pd-C (0.2 equiv) was added to a stirred methanol solution of 0.1 M methyl 1-Cbz-4-Boc-2-piperazinecarboxylate (A2) and the mixture was stirred for 3 hours at room temperature under hydrogen atmosphere. After completion of the reaction, the mixture was filtered, the filter cake was washed with methanol and the filtrate was evaporated under reduced pressure to give methyl 1-BOC-3-piperazinecarboxylate (A3) in 95% yield. The product was characterized as follows: 1H NMR (400 MHz, CDCl3, 300 K) δ 4.02 (1H, m), 3.74 (3H, s), 3.70 (1H, m), 3.43 (1H, m), 3.20 (1H, m), 3.04 (2H, m), 2.75 (1H, m), 2.14 (1H, m), 1.47 (9H, s). s).MS (ES+) C11H20N2O4 theoretical value 244, measured value: 267 (M + Na)+.

References

[1] Patent: WO2010/23480, 2010, A1. Location in patent: Page/Page column 44
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 23, p. 4241 - 4244
[3] Patent: WO2005/79799, 2005, A1. Location in patent: Page/Page column 18
[4] Patent: US5736539, 1998, A
[5] Patent: US6251902, 2001, B1

Methyl 4-Boc-piperazine-2-carboxylate synthesis

67-56-1
181955-79-3
129799-08-2
Synthesis of Methyl 4-Boc-piperazine-2-carboxylate from Methanol and 1,4-Bis(N-Boc)piperazine-2-carboxylic acid

Methyl 4-Boc-piperazine-2-carboxylate Preparation Products And Raw materials

Raw materials

Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Piperazine-2-carboxylic acid methyl ester dihydrochloride 1,4-Bis(N-Boc)piperazine-2-carboxylic acid Piperazine-2-carboxylic acid
N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid 2-Piperazinecarboxylic acid methyl ester Methanol Di-tert-butyl dicarbonate
Iodomethane 2-Pyrazinecarboxylic acid 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

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Preparation Products

1-Boc-3-hydroxymethyl-piperazine

Methyl 4-Boc-piperazine-2-carboxylate Suppliers

Global( 195)Suppliers
Supplier Tel Email Country ProdList Advantage
Lanzhou HuaHao Pharmaceutical Co., Ltd. 18189674620 761137152@qq.com China 490 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Yangzhou Siyu Chemical Co.,Ltd. 0514-87325867 sales@siyuchem.com China 370 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Supplier Advantage
Lanzhou HuaHao Pharmaceutical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Yangzhou Siyu Chemical Co.,Ltd. 55
Chembest Research Laboratories Limited 61
Alfa Aesar 84
Ark Pharm, Inc. 56
Energy Chemical 61
Capot Chemical Co., Ltd 66
Sichuan Guanghan Bio-Tech Co., Ltd 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56

View Lastest Price from Methyl 4-Boc-piperazine-2-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE pictures 2026-06-30 METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE
129799-08-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

Methyl 4-Boc-piperazine-2-carboxylate Spectrum

METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE(129799-08-2)1HNMR

129799-08-2(Methyl 4-Boc-piperazine-2-carboxylate)Related Search:

1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 4-Boc-1-Fmoc-2-piperazinecarboxylic acid (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
(S)-1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID 1-Boc-4-Fmoc-2-piperazinecarboxylic acid (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID METHYL 1-BOC-PIPERAZINE-2-CARBOXYLATE (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
(S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester 4-Boc-piperazine-2-carboxylic acid N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Methyl 4-Boc-piperazine-2-carboxylate (R)-N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid
Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate N-1-Boc-N-4-Cbz-2-piperazine carboxylic acid (R)-1-N-Boc-4-N-Fmoc-2-piperazine carboxylic acid

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4-N-BOC-PIPERAZINE-2-CRBOXYLIC ACID METHYL ESTER-HCl N-4-BOC-piperazine-2-carboxylic acid Methyl ester-HCl 1-Boc-piperazine-3-carboxylic acid Methyl ester 1,3-Piperazinedicarboxylicacid, 1-(1,1-diMethylethyl) 3-Methyl ester 1-O-tert-butyl 3-O-methyl piperazine-1,3-dicarboxylate METHYL 4N-BOC-PIPERAZINE-2-CARBOXYLATE 1-TERT-BUTYL-3-METHYL-PIPERAZINE-1,3-DICARBOXYLATE 4N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER N-4-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER PIPERAZINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-METHYL ESTER N-T-BUTOXYCARBONYL-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 1-N-Boc-piperazine-3-carboxylic acid methyl ester (R)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 4-Boc-2-Piperazinecarboxylic acid methyl ester Methyl (±)-4-Boc-piperazine-2-carboxylate N-4-Boc-2-Piperazinecarboxylic acid methyl ester, CAS 129799-08-2 Methyl 4-Boc-piperazine-2-carboxylate 129799-08-2 C11H20N2O4 pharmacetical Piperaizine