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4-Hydroxycoumarin

4-Hydroxycoumarin Structure
4-Hydroxycoumarin structure
CAS No.
1076-38-6
Chemical Name:
4-Hydroxycoumarin
Synonyms
4-HYDROXY-2H-CHROMEN-2-ONE;HydroxyCoumarin;4-Coumaryl alcohol;4-hydroxy-2h-1-benzopyran-2-on;COUMARINOL;4-HYDROXY-2H-1-BENZOPYRAN-2-ONE;4-Coumarinol;COUMARIN KIT;4-HydroxycouMa;4-HYDROXYCUMARIN
CBNumber:
CB0760607
Molecular Formula:
C9H6O3
Molecular Weight:
162.14
MDL Number:
MFCD00006856
MOL File:
1076-38-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:20:59
Product description Number Pack Size Price
4-Hydroxycoumarin 98% H23805 100g $74.2
4-Hydroxycoumarin 98% H23805 500g $218
4-Hydroxycoumarin analytical standard 40863 100MG $74.9
4-Hydroxycoumarin >98.0%(GC)(T) H0235 25g $57
4-Hydroxycoumarin >98.0%(GC)(T) H0235 250g $410
More product size
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4-Hydroxycoumarin Properties

Melting point 211-213 °C (lit.)
Boiling point 228.82°C (rough estimate)
Density 1.1734 (rough estimate)
vapor pressure 0.02Pa at 25℃
refractive index 1.4500 (estimate)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly)
form Liquid
pka 4.50±1.00(Predicted)
color Clear colorless to slightly yellow
Odor Very faint woody-medicinal odor with a with Aluminum chloride. nut-like, hcrbaccous tone
Water Solubility PRACTICALLY INSOLUBLE
BRN 129768
InChI 1S/C9H6O3/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5,10H
InChIKey VXIXUWQIVKSKSA-UHFFFAOYSA-N
SMILES OC1=CC(=O)Oc2ccccc12
LogP 1.6-2.31 at 21.2℃
CAS DataBase Reference 1076-38-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII X954ZLL2RD
NIST Chemistry Reference 4-Hydroxycoumarin(1076-38-6)
EPA Substance Registry System 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3100000
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29322980
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
REACH Registrations Active
NFPA 704
1
0 0

4-Hydroxycoumarin price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H23805 4-Hydroxycoumarin 98% 1076-38-6 100g $74.2 2026-04-30 Buy
Sigma-Aldrich H23805 4-Hydroxycoumarin 98% 1076-38-6 500g $218 2026-04-30 Buy
Sigma-Aldrich 40863 4-Hydroxycoumarin analytical standard 1076-38-6 100MG $74.9 2026-04-30 Buy
TCI Chemical H0235 4-Hydroxycoumarin >98.0%(GC)(T) 1076-38-6 25g $57 2026-04-30 Buy
TCI Chemical H0235 4-Hydroxycoumarin >98.0%(GC)(T) 1076-38-6 250g $410 2026-04-30 Buy
Product number Packaging Price Buy
H23805 100g $74.2 Buy
H23805 500g $218 Buy
40863 100MG $74.9 Buy
H0235 25g $57 Buy
H0235 250g $410 Buy

4-Hydroxycoumarin Chemical Properties,Uses,Production

Chemical Properties

Yellow powder or chunks or Slightly yellow needle-like crystals. freely soluble in ethanol, ether and hot water. brown in color with ferric chloride.

Uses

4-Hydroxycoumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarins are a very important class of biologically active drugs which are widely used as anticoagulants-Warfarin and Acenocoumarol.

Uses

4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.

Uses

4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes.
RuCl3.nH2O catalyzed synthesis of biscoumarins
Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst.

Definition

ChEBI: 4-hydroxycoumarin is a hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group. It is a conjugate acid of a 4-hydroxycoumarin(1-).

Synthesis Reference(s)

The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630

Flammability and Explosibility

Not classified

Synthesis

4-Hydroxycoumarin is prepared by the reaction of o-hydroxyacetophenone and Diethyl carbonate. The steps are as follows:
General procedure: To a stirred mixture (1.15 mmol) and sodium hydride (138 mg, 5.75 mmol) in 5 ml dry toluene, a solution of the diethyl carbonate (1.15 mmol) in dry toluene was dropped. The mixture was reacted at 0°C for 30 min, then heated to reflux and reacted for another 4 h. The reaction mixture was quenched with water (20 mL) at ice bath and neutralized to pH 7 with 2 N HCl. The precipitate was filtered, washed with cold water and dried to get 6a-f. 1.2.1.1. 4-Hydroxy-2H-chromen-2-one (6a) White solidyield: 95; 1H NMR (600 MHz, DMSO-d6) δ 12.53 (s, 1H), 7.83 (d, J = 7.2 Hz, 1H), 7.65 (d, J = 7.8 Hz, 1H), 7.38-7.34 (m, 2H), 5.60 (s, 1H).
4-Hydroxycoumarin synthesis

Purification Methods

Crystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]

References

[1] Synthetic Communications, 2001, vol. 31, # 8, p. 1195 - 1200
[2] Journal of the American Chemical Society, 2010, vol. 132, # 1, p. 185 - 194
[3] New Journal of Chemistry, 2018, vol. 42, # 16, p. 13985 - 13997
[4] Organic Letters, 2017, vol. 19, # 4, p. 934 - 937
[5] Patent: US5959109, 1999, A

4-Hydroxycoumarin Preparation Products And Raw materials

Raw materials

Sodium hydride Sodium acetate Acetoxyacetic acid Sodium sulfate Mineral oil
ACETYLSALICYLIC ACID METHYL ESTER Benzene Ethyl acetate Hydrochloric acid Sodium hydroxide
2'-Hydroxyacetophenone Diethyl carbonate O-ACETYLSALICYLOYL CHLORIDE

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Preparation Products

Warfarin Bromadiolone Brodifacoum p-Coumaric acid reversible temperature indication paint (III)
Flocoumafen Coumatetralyl ACENOCOUMAROL 4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE

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4-Hydroxycoumarin Suppliers

Global( 675)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5233 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 sales8@hbganmiao.com China 300 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019 admin@86-ss.com China 999 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21588 55
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Hebei Ganmiao New material Technology Co., LTD 		58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55

View Lastest Price from 4-Hydroxycoumarin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxycoumarin pictures 2026-05-25 4-Hydroxycoumarin
1076-38-6
 US $0.00 / Kg/Drum 1KG 98%min HPLC 10kgs WUHAN FORTUNA CHEMICAL CO., LTD
4-Hydroxycoumarin pictures 2026-05-24 4-Hydroxycoumarin
1076-38-6
 US $100.00-75.00 / g 1g 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
4-Hydroxycoumarin pictures 2026-05-21 4-Hydroxycoumarin
1076-38-6
 US $0.00 / KG 1KG 99% 100mt/year Jinan Finer Chemical Co., Ltd
  • 4-Hydroxycoumarin pictures
  • 4-Hydroxycoumarin
    1076-38-6
  • US $0.00 / Kg/Drum
  • 98%min HPLC
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • 4-Hydroxycoumarin pictures
  • 4-Hydroxycoumarin
    1076-38-6
  • US $100.00-75.00 / g
  • 99%
  • HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

4-Hydroxycoumarin Spectrum

4-Hydroxycoumarin(1076-38-6)MS4-Hydroxycoumarin(1076-38-6)1HNMR4-Hydroxycoumarin(1076-38-6)13CNMR4-Hydroxycoumarin(1076-38-6)IR14-Hydroxycoumarin(1076-38-6)IR24-Hydroxycoumarin(1076-38-6)Raman

1076-38-6(4-Hydroxycoumarin)Related Search:

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Warfarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) r-(+)-3-acetonybenzyl)-4-hydroxycoumarin,(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin

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4-hydroxy-2h-1-benzopyran-2-on COUMARINOL HYDROXYCOUMARIN, 4- 2H-1-BENZOPYRAN-2-ONE, 4-HYDROXY- 4-coumarinyl alcohol 4-HYDROXY-CHROMEN-2-ONE 4-HYDROXYCOUMARIN 4-HYDROXYCUMARIN 4-HYDROXY-1-BENZOPYRAN-2-ONE 4-HYDROXY-2H-1-BENZOPYRAN-2-ONE 4-HYDROXY-2H-CHROMEN-2-ONE AKOS BBS-00000696 4-Coumarinol 4-Coumaryl alcohol 4-HYDROXYCOUMARIN FOR SYNTHESIS 4-hydroxy-couMarin, 4-hydroxy-2H-benzopyran-2-one, 4-hydroxy-2-chroMenone, 4-hydroxycouMarin, 4-hydroxy-2H-benzopyran-2-one, 4-hydroxy-2H-benzo-1-pyran-2-one, 4-hydroxy-2H-benzo[b]pyran-2-one Warfarin EP IMpurity-B 4-HydroxycouMa Warfarin sodium EP Impurity B 4-Hydroxycoumarin Vetec(TM) reagent grade, 98% Warfarin Impurity 2(Warfarin Impurity B) 7-hydroxy-1-benzopyran-2-one 4-HydroxycoumarinN 4-Hydroxycoumarin 1076-38-6 4-Hydroxy-1-benzopyran-2-one 1076-38-6 4-HYDROXYCOUMARIN, FOR FLUORESCENCE 4-Hydroxycoumarin99% HydroxyCoumarin 4-(3-hydroxyprop-1-enyl)phenol 4-HYDROXYCOUMARIN (98.0%) CHROMANONE, 4-(RG) HYDROXYCOUMARIN, 4-(RG) 1-BENZOPYRAN-2-ONE,4-HYDROXY- 4-hydroxy-coumari 4-Hydroxycoumarine Benzotertonicacid Benzotetronic acid Coumarin, 4-hydroxy- 4-Hydroxycoumarin , (4-hydroxy-1-benzopyran-2-one) β-Hydroxy-o-couMaric lactone 4-Hydroxycoumarin, 98+% 4-Hydroxy-2H-1-benzopyrene-2-one 2-Hydroxychromen-4-one Warfarin Impurity B 4-Hydroxy-2H-1-benzopyran-2-one (4- 4-Hydroxycoumarin> Warfarin EP Impurity B (4-Hydroxy Coumarin) Warfarin Impurity 2（Warfarin EP Impurity B） 4-Hydroxycoumarin ISO 9001：2015 REACH 4-Hydroxycoumarin,HPLC≥98% 4-HYDROXYCOMARINS Warfarin Impurity BQ: What is Warfarin Impurity B Q: What is the CAS Number of Warfarin Impurity B Q: What is the storage condition of Warfarin Impurity B Q: What are the applications of Warfarin Impurity B 2-hydroxy-4H-chromen-4-one Warfarin Sodium Impurity B 4-hydroxy-2H-1-benzopyran-2-one(4-hydroxycoumarin) C14230600 4-Hydroxycoumarin COUMARIN KIT Warfarin Sodium Imp. B (EP): 4-hydroxy-2H-1-benzopyran-2-one