ChemicalBook >> CAS DataBase List >>(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride structure

CAS No.: 171752-68-4

Chemical Name:: (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

Synonyms: methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride;Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride;TDF-DA-M1;Tadalafile N-2;3]dioxol-5-yl)-2;CHEMPACIFIC 51475;Tetrahydrocarbaline;Aliskiren Impurity 65;Tildenafil Impurity 25;Tadalafi Impurity 1 HCI

CBNumber:: CB0840958

Molecular Formula:: C20H18N2O4.ClH

Molecular Weight:: 386.83

MDL Number:: MFCD09842269

MOL File:: 171752-68-4.mol

Last updated:2026-05-27 22:56:10

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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Properties

Melting point	239-241 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly)
form	Solid
color	Off-White to Pale Yellow
Stability	Hygroscopic
InChI	InChI=1/C20H18N2O4.ClH/c1-24-20(23)15-9-13-12-4-2-3-5-14(12)21-19(13)18(22-15)11-6-7-16-17(8-11)26-10-25-16;/h2-8,15,18,21-22H,9-10H2,1H3;1H/t15-,18-;/s3
InChIKey	ROYJOKDTCKPQHK-QHWQFTOMNA-N
SMILES	C12[C@@H](C3=CC=C4OCOC4=C3)N[C@H](CC=1C1C(=CC=CC=1)N2)C(OC)=O.Cl \|&1:1,12,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-R239590-5G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	5g	$212	2026-06-03	Buy
TRC	TRC-R239590-25G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	25g	$668	2026-06-03	Buy
TRC	TRC-R239590-10G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	10g	$329	2026-06-03	Buy
Synthonix	M21776	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	171752-68-4	5g	$17	2026-05-06	Buy
Synthonix	M21776	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	171752-68-4	10g	$20	2026-05-06	Buy

Product number	Packaging	Price	Buy
TRC-R239590-5G	5g	$212	Buy
TRC-R239590-25G	25g	$668	Buy
TRC-R239590-10G	10g	$329	Buy
M21776	5g	$17	Buy
M21776	10g	$20	Buy

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Chemical Properties, Uses, Production

Uses

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride is a key pharmaceutical intermediate used in the synthesis of the drug tadalafil. Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor primarily used to treat erectile dysfunction and benign prostatic hyperplasia in men.

Preparation

D-tryptophan methyl ester hydrochloride and piperonal chloride dissolved in redistilled tetrahydrofuran and then added trifluoroacetic acid. Stir the reaction at 30 ° C for 10 h under the protection of nitrogen. Add sodium triacetoxyborohydride and continue the reaction for 3 hours. After the reaction is monitored by a TLC plate, the reaction solution is concentrated to about 10 mL, deionized water is added, and extracted with ethyl acetate twice. Saturated sodium chloride was washed twice, and dried under reduced pressure to obtain (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. The yield was 86.95%, the purity was 98.76%.

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Suppliers

Global Suppliers ( 252)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Chenrui Technology Co., Ltd.	00-15634801555 15634801555	524585886@qq.com	China	4	58
JinanGongchuang Pharmaceutical Technology Co. Ltd..	88065293 13287783460	3166282224@qq.com	China	40	58
Shandong Haiwo Biological Technology Co., Ltd.	0531-87586188 13046003282	3473674613@qq.com	China	33	58
Aobolihui	0917-18691729 18691729963	2553382659@qq.com	China	4726	58
Jinan Hongwan Biotechnology Co., Ltd.	58767175 13220585822	1256200339@qq.com	China	62	58
Shandong Haiyou Furuida Pharmaceutical Co., Ltd.	0531-81213160 18369049521	244846234@qq.com	China	30	58
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Tianjin Chenrui Technology Co., Ltd.	58
JinanGongchuang Pharmaceutical Technology Co. Ltd..	58
Shandong Haiwo Biological Technology Co., Ltd.	58
Aobolihui	58
Jinan Hongwan Biotechnology Co., Ltd.	58
Shandong Haiyou Furuida Pharmaceutical Co., Ltd.	58
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride 171752-68-4	$2.00	1KG	99.99%	500KG	.GZ HONESTCHEM CO.,LTD
2026-09-16	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride 171752-68-4	$1.00	1KG	99.9%	500KG	.GZ HONESTCHEM CO.,LTD
2026-09-15	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 171752-68-4		1kg	99%	20ton	Jinan Jianfeng Chemical Co., Ltd

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride
171752-68-4
$2.00
99.99%
.GZ HONESTCHEM CO.,LTD

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride
171752-68-4
$1.00
99.9%
.GZ HONESTCHEM CO.,LTD

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
171752-68-4
$0.00
99%
Jinan Jianfeng Chemical Co., Ltd

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Spectrum

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride(171752-68-4)¹HNMR

171752-68-4 ((1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride) Related Search:

Tadalafil Impurity 11 Tadalafil EP IMpurity G (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester cis-ent-Tadalafil cis-Tadalafil

3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (S)-1-Boc-3-hydroxypiperidine Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Trelagliptin succinate

Tadalafil Hydroxytyrosol Benoxinate Hydrochloride Chloropretadalafil D-Tryptophan methyl ester hydrochloride

Tadalafil Impurity 39 Tadalafil Impurity 62 Benzhydryl 6,6-dihydropenicillic acid 1-oxide[tazobactam intermediate]

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INTERMEDIATES OF TADALAFIL:(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, CIS ISOMER, HYDROCHLORIDE 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro- 1H-Pyrido[3,4-b]indole-3-carboxylicacid methylester, monohydrochloride, (1R,3R)- (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE CHEMPACIFIC 51475 cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride (1R, 3R)-9H-PYRIDO[3,4-B] INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1- (3,4-METHYLENDIOXYPHENYL), METHYL ESTER, HYDROCHLORIDE (1R,3R)-1-BENZO[1,3]DIOXOL-5-YL-2,3,4,9-TETRAHYDRO-1H-Β-CARBOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, hydrochloride (1:1), (1R,3R) methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride (1R,3R)-9h-pyrido[3,4-b]indole-3-carboxylicacid,1,2,3,4 -tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride(Tadalafil Intermediates) (1R,3R)-9H-Pyrido[3,4-B]Indol-3-Carboxylic Acid 1,2,3,4-Terahydro-1-(3,4-Methylendioxyphenyl),Methyl Ester Hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORID (1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride Tadalafil Impurity 1 HCl Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride cis-(1r,3r)-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylic acid methyl ester cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl) -9H-pyrido[3,4-b]indole-3-carboxy cis-(1R,3R)-1,2,3,4-Tetrah Tadalafil impurity 20/methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride (1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic Tadalafil intermediate-API (1R,3R)-METHYL 1-(BENZO[D][1,3]DIOXOL-5-YL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE HCL cis-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, (1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, 1,2,3, 4-tetrahydro-1 - (3, 4-methylene dioxyphenyl), Tadalafil intermediates，(1R,3R)-9H-pyrido[3,4-B]indole-3- carboxylic acid, 1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl), methyl ester, hydrochloride Tadalafile N-2 (1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-te... Intermediate of Tadalafil 2 methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL) (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1:1) (1R3R)-9H-PYRIDO[3.4-BJINDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3.4-METHYLENEDIOXYPH ENYL) Tetrahydrocarbaline Cis - (1R, 3R) -1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl) -9H pyridino [3,4-B] indole-3-carboxylic acid methyl ester hydrochloride TDF-DA-M1 TadalafilCis-intermediate Tadalafil Impurity 16 HCl Aliskiren Impurity 65 Tadalafil Impurity 22 HCl Tadanafil intermediates 2 (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester monohydrochlor 3]dioxol-5-yl)-2 3R)-Methyl 1-(benzo[d][1 4-b]indole-3-carboxylate hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE (1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-carboxylic acid methyl ester HCl Tadalafil Impurity 70 HCl Tildenafil Impurity 25 Tadalafi Impurity 1 HCI (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL) 171752-68-4 17152-68-4 C20H18N2O4HCl Intermediate of Tadalafil