ChemicalBook >> CAS DataBase List >>(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride structure

CAS No.: 171752-68-4

Chemical Name:: (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

Synonyms: methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride;Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride;TDF-DA-M1;Tadalafile N-2;3]dioxol-5-yl)-2;CHEMPACIFIC 51475;Tetrahydrocarbaline;Aliskiren Impurity 65;Tildenafil Impurity 25;Tadalafi Impurity 1 HCI

CBNumber:: CB0840958

Molecular Formula:: C20H18N2O4.ClH

Molecular Weight:: 386.83

MDL Number:: MFCD09842269

MOL File:: 171752-68-4.mol

Last updated:2026-05-27 22:56:10

Product description	Number	Pack Size	Price
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	TRC-R239590-5G	5g	$212
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	TRC-R239590-25G	25g	$668
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	TRC-R239590-10G	10g	$329
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	M21776	5g	$17
(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	M21776	10g	$20
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(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Properties

Melting point	239-241 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly)
form	Solid
color	Off-White to Pale Yellow
Stability	Hygroscopic
InChI	InChI=1/C20H18N2O4.ClH/c1-24-20(23)15-9-13-12-4-2-3-5-14(12)21-19(13)18(22-15)11-6-7-16-17(8-11)26-10-25-16;/h2-8,15,18,21-22H,9-10H2,1H3;1H/t15-,18-;/s3
InChIKey	ROYJOKDTCKPQHK-QHWQFTOMNA-N
SMILES	C12[C@@H](C3=CC=C4OCOC4=C3)N[C@H](CC=1C1C(=CC=CC=1)N2)C(OC)=O.Cl \|&1:1,12,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-R239590-5G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	5g	$212	2026-06-03	Buy
TRC	TRC-R239590-25G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	25g	$668	2026-06-03	Buy
TRC	TRC-R239590-10G	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride	171752-68-4	10g	$329	2026-06-03	Buy
Synthonix	M21776	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	171752-68-4	5g	$17	2026-05-06	Buy
Synthonix	M21776	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 97%	171752-68-4	10g	$20	2026-05-06	Buy

Product number	Packaging	Price	Buy
TRC-R239590-5G	5g	$212	Buy
TRC-R239590-25G	25g	$668	Buy
TRC-R239590-10G	10g	$329	Buy
M21776	5g	$17	Buy
M21776	10g	$20	Buy

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Chemical Properties,Uses,Production

Uses

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride is a key pharmaceutical intermediate used in the synthesis of the drug tadalafil. Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor primarily used to treat erectile dysfunction and benign prostatic hyperplasia in men.

Preparation

D-tryptophan methyl ester hydrochloride and piperonal chloride dissolved in redistilled tetrahydrofuran and then added trifluoroacetic acid. Stir the reaction at 30 ° C for 10 h under the protection of nitrogen. Add sodium triacetoxyborohydride and continue the reaction for 3 hours. After the reaction is monitored by a TLC plate, the reaction solution is concentrated to about 10 mL, deionized water is added, and extracted with ethyl acetate twice. Saturated sodium chloride was washed twice, and dried under reduced pressure to obtain (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride. The yield was 86.95%, the purity was 98.76%.

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Suppliers

Global( 245)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Luning Pharmaceutical Co., Ltd.	+8618753388868	sale@lntzkg.com	China	7	58
Jinan Jianfeng Chemical Co., Ltd	+86-0531-88110457 +8615562555968	info@pharmachemm.com	China	310	58
HangZhou RunYan Pharma Technology Co.,LTD.	+8618882027439	sales2@runyanpharma.com	China	302	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Apeloa production Co.,Limited	+8619933239880	admin@apcl.com.cn	China	861	58
S&Y Biochem Co.,Ltd	+86-17774091612; +8617774091612	marketing@sybiochem.com	China	284	58
Shandong Xuhuang New material CoLTD	+86-15095020839 +86-17660422208		China	726	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60

Supplier	Advantage
Shandong Luning Pharmaceutical Co., Ltd.	58
Jinan Jianfeng Chemical Co., Ltd	58
HangZhou RunYan Pharma Technology Co.,LTD.	58
Henan Bao Enluo International TradeCo.，LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Apeloa production Co.,Limited	58
S&Y Biochem Co.,Ltd	58
Shandong Xuhuang New material CoLTD	58
Capot Chemical Co.,Ltd.	60

View Lastest Price from (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-15	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride 171752-68-4	$2.00	1KG	99.99%	500KG	.GZ HONESTCHEM CO.,LTD
2026-06-15	methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride 171752-68-4	$1.00	1KG	99.9%	500KG	.GZ HONESTCHEM CO.,LTD
2026-06-14	(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 171752-68-4	$1.00		98	1000	S&Y Biochem Co.,Ltd

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride
171752-68-4
$2.00
99.99%
.GZ HONESTCHEM CO.,LTD

methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride
171752-68-4
$1.00
99.9%
.GZ HONESTCHEM CO.,LTD

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride
171752-68-4
$1.00
98
S&Y Biochem Co.,Ltd

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride Spectrum

(1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride(171752-68-4)¹HNMR

171752-68-4((1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride)Related Search:

BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] cis-ent-Tadalafil cis-Tadalafil 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

(S)-1-Boc-3-hydroxypiperidine Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Trelagliptin succinate Tadalafil Hydroxytyrosol

Benoxinate Hydrochloride Chloropretadalafil D-Tryptophan methyl ester hydrochloride (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Tadalafil EP IMpurity G

Tadalafil Impurity 11 Tadalafil Impurity 39 Tadalafil Impurity 62

1of4

INTERMEDIATES OF TADALAFIL:(1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, CIS ISOMER, HYDROCHLORIDE 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro- 1H-Pyrido[3,4-b]indole-3-carboxylicacid methylester, monohydrochloride, (1R,3R)- (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE CHEMPACIFIC 51475 cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride (1R, 3R)-9H-PYRIDO[3,4-B] INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1- (3,4-METHYLENDIOXYPHENYL), METHYL ESTER, HYDROCHLORIDE (1R,3R)-1-BENZO[1,3]DIOXOL-5-YL-2,3,4,9-TETRAHYDRO-1H-Β-CARBOLINE-3-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-, methyl ester, hydrochloride (1:1), (1R,3R) methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate,hydrochloride (1R,3R)-9h-pyrido[3,4-b]indole-3-carboxylicacid,1,2,3,4 -tetrahydro-1-(3,4-methylenedioxyphenyl), methyl ester, hydrochloride(Tadalafil Intermediates) (1R,3R)-9H-Pyrido[3,4-B]Indol-3-Carboxylic Acid 1,2,3,4-Terahydro-1-(3,4-Methylendioxyphenyl),Methyl Ester Hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORID (1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride Tadalafil Impurity 1 HCl Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride cis-(1r,3r)-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9h-pyrido(3,4-b)indole-3-carboxylic acid methyl ester cis-(1R,3R)-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl) -9H-pyrido[3,4-b]indole-3-carboxy cis-(1R,3R)-1,2,3,4-Tetrah Tadalafil impurity 20/methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride (1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic Tadalafil intermediate-API (1R,3R)-METHYL 1-(BENZO[D][1,3]DIOXOL-5-YL)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLATE HCL cis-1,2,3,4-Tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, (1R, 3R) -9H-pyridyl [3,4-B] indole-3-carboxylic acid, 1,2,3, 4-tetrahydro-1 - (3, 4-methylene dioxyphenyl), Tadalafil intermediates，(1R,3R)-9H-pyrido[3,4-B]indole-3- carboxylic acid, 1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl), methyl ester, hydrochloride Tadalafile N-2 (1R,3R)-9H-pyrido[3,4-B]indole-3-carboxylic acid, 1,2,3,4-te... Intermediate of Tadalafil 2 methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL) (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride (1:1) (1R3R)-9H-PYRIDO[3.4-BJINDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3.4-METHYLENEDIOXYPH ENYL) Tetrahydrocarbaline Cis - (1R, 3R) -1,2,3,4-tetrahydro-1- (3,4-methylenedioxyphenyl) -9H pyridino [3,4-B] indole-3-carboxylic acid methyl ester hydrochloride TDF-DA-M1 TadalafilCis-intermediate Tadalafil Impurity 16 HCl Aliskiren Impurity 65 Tadalafil Impurity 22 HCl Tadanafil intermediates 2 (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester monohydrochlor 3]dioxol-5-yl)-2 3R)-Methyl 1-(benzo[d][1 4-b]indole-3-carboxylate hydrochloride (1R,3R)-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-1-(3,4-METHYLENEDIOXYPH ENYL), METHYL ESTER, HYDROCHLORIDE (1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-carboxylic acid methyl ester HCl Tadalafil Impurity 70 HCl Tildenafil Impurity 25 Tadalafi Impurity 1 HCI 171752-68-4 17152-68-4 C20H18N2O4HCl Intermediate of Tadalafil