2-N-Boc-amino-thiazole-5-carboxylic acid
- CAS No.
- 302964-02-9
- Chemical Name:
- 2-N-Boc-amino-thiazole-5-carboxylic acid
- Synonyms
- 2-Boc-aminothiazole-5-carboxylic acid;2-N-Boc-Amino-thiazole-5-carboxylic acid, CAS 302964-02-9;2-Amino-1,3-thiazole-5-carboxylic acid, N-BOC protected 97%;2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid;2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic aci...;2-(N-Boc-amino)thiazole-5-carboxylic acid dasatinib intermediate;5-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;2-N-Boc-AMino-thiazole-5-carboxylicacid/2-(tert-butoxycarbonylaMino)thiazole-5-carboxylicacid
- CBNumber:
- CB11119481
- Molecular Formula:
- C9H12N2O4S
- Molecular Weight:
- 244.27
- MDL Number:
- MFCD06796614
- MOL File:
- 302964-02-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 220-222°(dec) |
|---|---|
| Density | 1.406±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 5.53±0.70(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | 1S/C9H12N2O4S/c1-9(2,3)15-8(14)11-7-10-4-5(16-7)6(12)13/h4H,1-3H3,(H,12,13)(H,10,11,14) |
| InChIKey | QNFLEDLPOVONCN-UHFFFAOYSA-N |
| SMILES | [s]1c(ncc1C(=O)O)NC(=O)OC(C)(C)C |
| CAS DataBase Reference | 302964-02-9 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280 |
| Hazard Codes | Xi |
| Risk Statements | 43-36/37/38 |
| Safety Statements | 36/37-36-26 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Skin Sens. 1 |
2-N-Boc-amino-thiazole-5-carboxylic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00310 | 2-(N-BOC)-Aminothiazole-5-carboxylic acid | 302964-02-9 | 1g | $197 | 2026-04-30 | Buy |
| TCI Chemical | B4552 | 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid >98.0%(HPLC)(T) | 302964-02-9 | 1g | $461 | 2026-04-30 | Buy |
| TCI Chemical | B4552 | 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic Acid >98.0%(HPLC)(T) | 302964-02-9 | 200mg | $153 | 2026-04-30 | Buy |
| AstaTech | 65332 | 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 97% | 302964-02-9 | 1G | $34 | 2026-04-30 | Buy |
| AstaTech | 65332 | 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 97% | 302964-02-9 | 5G | $95 | 2026-04-30 | Buy |
2-N-Boc-amino-thiazole-5-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
A reactant used in the preparation of 2-aminocarboxamidothiazoles as inhibitors of Src-family kinase.
Synthesis
302964-01-8
302964-02-9
General procedure for the synthesis of 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid from ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate: To a vigorously stirred suspension of ethyl 2-(tert-butoxycarbonylamino)thiazole-5-carboxylate (4.2 g, 15 mmol) in methanol (11 mL) was slowly added an aqueous 2 M NaOH solution (22 mL, 44.0 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated under vacuum by rotary evaporator to remove methanol. The pH was adjusted to 1-2 by adding aqueous 6 N HCl dropwise to the residual aqueous suspension. the mixture was stirred for 1 h, during which time it was occasionally sonicated to promote precipitation. The resulting white solid was collected by filtration, washed thoroughly with deionized water and dried in a vacuum drying oven to afford 2-(tert-butoxycarbonylamino)thiazole-5-carboxylic acid (3.7 g, 100% yield). Mass spectrometry analysis showed (M + H-Boc)+ = 145.
References
[1] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 109
[2] Patent: CN106674150, 2017, A. Location in patent: Paragraph 0022-0026
[3] Patent: US2004/54186, 2004, A1. Location in patent: Page 23
[4] Synthetic Communications, 2017, vol. 47, # 17, p. 1610 - 1621
[5] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1621 - 1628
2-N-Boc-amino-thiazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 2-N-Boc-amino-thiazole-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
302964-02-9
|
$150.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID
302964-02-9
- $150.00
- 98%
- Career Henan Chemical Co
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