8-Bromo-2-methyl-quinoline
- CAS No.
- 61047-43-6
- Chemical Name:
- 8-Bromo-2-methyl-quinoline
- Synonyms
- 8-Bromoquinaldine;2-Methyl-8-bromoquinoline;8-Bromo-2-methyl-quinoline;Quinoline, 8-bromo-2-methyl-;8-Bromo-2-methylquinoline >7-Trifluoromethyl-8-hydroxyquinoline;8-BROMO-2-METHYL-QUINOLINE ISO 9001：2015 REACH
- CBNumber:
- CB1157974
- Molecular Formula:
- C10H8BrN
- Molecular Weight:
- 222.08
- MDL Number:
- MFCD04966997
- MOL File:
- 61047-43-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 63-65℃ |
|---|---|
| Boiling point | 132°C/0.1mmHg(lit.) |
| Density | 1.488 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.17±0.50(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | InChI=1S/C10H8BrN/c1-7-5-6-8-3-2-4-9(11)10(8)12-7/h2-6H,1H3 |
| InChIKey | GQPRZSFQSOEDNV-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2Br)C=CC=1C |
| CAS DataBase Reference | 61047-43-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| HS Code | 2933.49.7000 | |||||||||
| NFPA 704 |
|
8-Bromo-2-methyl-quinoline price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3444 | 8-Bromo-2-methylquinoline >98.0%(GC)(T) | 61047-43-6 | 1g | $44 | 2026-04-30 | Buy |
| TCI Chemical | B3444 | 8-Bromo-2-methylquinoline >98.0%(GC)(T) | 61047-43-6 | 5g | $142 | 2026-04-30 | Buy |
| Biosynth | FB168383 | 8-Bromo-2-methylquinoline | 61047-43-6 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FB168383 | 8-Bromo-2-methylquinoline | 61047-43-6 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FB168383 | 8-Bromo-2-methylquinoline | 61047-43-6 | 1g | $900 | 2026-06-04 | Buy |
8-Bromo-2-methyl-quinoline Chemical Properties, Uses, Production
Uses
8-Bromo-2-methylquinoline is a quinoline derivative that can be used as a pharmaceutical intermediate.
Synthesis
615-36-1
123-73-9
61047-43-6
To a 6N hydrochloric acid (300 mL) solution of o-bromoaniline (100 g, 0.58 mol) was slowly added trans-2-butenal (81 g, 1.1 mol) at room temperature. The reaction mixture was heated to 100 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature, alkalized to pH 8-9 with ammonium hydroxide solution and subsequently extracted with ether (3 × 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (12:1 to 10:1, v/v) as eluent to afford 8-bromo-2-methylquinoline as a white solid (59 g, 54% yield). Mass spectrometry (ESI) analysis: calculated value for C10H8BrN was 222.1; measured value was 223 [M + H]+.
References
[1] Patent: WO2010/101949, 2010, A1. Location in patent: Page/Page column 116; 117
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 4066 - 4084
[3] Patent: WO2009/80675, 2009, A1. Location in patent: Page/Page column 14
[4] Arkivoc, 2015, vol. 2015, # 3, p. 38 - 51
8-Bromo-2-methyl-quinoline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai RenYue Chemical Technology Co., Ltd. | 021-62219190; 18321139117 | 316441092@qq.com | China | 3000 | 55 |
| Hebei Fanbo Pharmaceutical Technology Co., Ltd. | 15588346797 | fanbomedical@163.com | China | 628 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| EnciPharmatech Co., Ltd | 025-52714267-66 13813902930 | stephen_shengll@hotmail.com | China | 231 | 64 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
View Latest Price from 8-Bromo-2-methyl-quinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 8-Bromo-2-methylquinoline
61047-43-6
|
$3.90-5.90 | 1KG | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | ||
 |
2021-07-13 | 8-Bromo-2-methylquinoline
61047-43-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | 8-Bromo-2-methylquinoline
61047-43-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 8-Bromo-2-methylquinoline
61047-43-6
- $3.90-5.90
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 8-Bromo-2-methylquinoline
61047-43-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 8-Bromo-2-methylquinoline
61047-43-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
