Methyl 3,5-dihydroxybenzoate
- CAS No.
- 2150-45-0
- Chemical Name:
- Methyl 3,5-dihydroxybenzoate
- Synonyms
- AKOS 227-38;RARECHEM AL BF 0252;METHYL-A-RESORCYLATE;ALPHA-RESORCYLIC ACID MET;METHYL 2,6-DIHYDROXYBENZOATE;Methyl2,6-Dihydroxybenzoate>Dihydroxybenziocacidmethylester;Methyl 2,6-dihydroxybenzoate 97%;GAMMA-RESORCYLIC ACID METHYL ESTER;ALPHA-RESORCYLIC ACID METHYL ESTER
- CBNumber:
- CB1192188
- Molecular Formula:
- C8H8O4
- Molecular Weight:
- 168.15
- MDL Number:
- MFCD00002289
- MOL File:
- 2150-45-0.mol
- MSDS File:
- SDS
| Melting point | 67-70 °C (lit.) |
|---|---|
| Boiling point | 253.6±20.0 °C(Predicted) |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.24±0.10(Predicted) |
| color | Light Brown |
| InChI | InChI=1S/C8H8O4/c1-12-8(11)7-5(9)3-2-4-6(7)10/h2-4,9-10H,1H3 |
| InChIKey | WCQZCKUNZVMBDC-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=C(O)C=CC=C1O |
| LogP | 2.290 (est) |
| CAS DataBase Reference | 2150-45-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 3,5-dihydroxybenzoate price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 432792 | Methyl 2,6-dihydroxybenzoate 97% | 2150-45-0 | 1g | $34 | 2023-01-07 | Buy |
| TCI Chemical | D1461 | Methyl 2,6-Dihydroxybenzoate >98.0%(GC)(T) | 2150-45-0 | 5g | $54 | 2026-04-30 | Buy |
| TCI Chemical | D1461 | Methyl 2,6-Dihydroxybenzoate >98.0%(GC)(T) | 2150-45-0 | 25g | $181 | 2026-04-30 | Buy |
| Biosynth | FM71118 | Methyl 2,6-dihydroxybenzoate | 2150-45-0 | 50g | $150 | 2026-06-04 | Buy |
| Biosynth | FM71118 | Methyl 2,6-dihydroxybenzoate | 2150-45-0 | 25g | $150 | 2026-06-04 | Buy |
Methyl 3,5-dihydroxybenzoate Chemical Properties, Uses, Production
Uses
Methyl 2,6-dihydroxybenzoate may be used for the preparation of methyl 2-hydroxy-6-methoxybenzoate and oxamyl propionic acid.
Definition
ChEBI: Methyl 2,6-dihydroxybenzoate is a member of phenols and a benzoate ester. It is functionally related to a salicylic acid.
General Description
Methyl 2,6-dihydroxybenzoate can be synthesized from 2,6-dihydroxybenzoic acid. Multiple fluorescences in methyl 2,6-dihydroxybenzoate have been investigated. Its short wavelength (387) and long wavelength (500) emissions are reported to arise from extramolecularly hydrogen-bonded and intramolecularly hydrogen-bonded species.
Synthesis
303-07-1
2150-45-0
The general procedure for the synthesis of methyl 2,6-dihydroxybenzoate from 2,6-dihydroxybenzoic acid is as follows: a) 80% sodium hydride (10.00 g, 333.3 mmol) was dissolved in N,N-dimethylformamide (45 mL) under argon protection and the solution was cooled to 0°C. Subsequently, a solution of 2,6-dihydroxybenzoic acid (48.88 g, 317.1 mmol) in N,N-dimethylformamide (50 mL) was slowly added over 45 minutes. After stirring for 45 minutes, iodomethane (21.0 mL, 337 mmol) was added dropwise over 20 minutes. The reaction mixture was stirred at room temperature for 70 hours. Upon completion of the reaction, the mixture was diluted with dichloromethane and filtered through a silica gel plug, using dichloromethane as the eluent. Finally, the solvent was evaporated to afford the target product methyl 2,6-dihydroxybenzoate (35.22 g, 66.1% yield). The product was characterized by 1H NMR (250 MHz, DMSO-d6): δ 9.91 (s, 2H), 7.09 (t, J = 1.2 Hz, J = 2.5 Hz, 1H), 6.37 (d, J = 1.1 Hz, 2H), 3.78 (s, 3H).
References
[1] Patent: US6204294, 2001, B1
[2] Patent: US4663344, 1987, A
[3] Patent: US6200981, 2001, B1
Methyl 3,5-dihydroxybenzoate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Endesa Bio-tech Co., Ltd. | 025-58862853 18915922038 | sales@endesachem.com | China | 590 | 58 |
| Nanjing Ze Feng biological medicine technology Co., Ltd. | 18851912129 18851912129; | 1670471576@qq.com | China | 794 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 859 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from Methyl 3,5-dihydroxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
|
$1.00-101.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-08-12 | METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
- $1.00-101.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- METHYL 3,5-DIHYDROXYBENZOATE
2150-45-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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