3-Aminocarbonyl-1-Boc-pyrrolidine
- CAS No.
- 122684-34-8
- Chemical Name:
- 3-Aminocarbonyl-1-Boc-pyrrolidine
- Synonyms
- TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE;1-Boc-3-pyrrolidinecarboxamide;1-BOC-PYRROLIDINE-3-CARBOXAMIDE;1-BOC-PYRROLIDINE-3-CARBOXYAMIDE;3-AMINOCARBONYL-1-BOC-PYRROLIDINE;(S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE;3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP;1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide;TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB1205707
- Molecular Formula:
- C10H18N2O3
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD04116210
- MOL File:
- 122684-34-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 117.0 to 121.0 °C |
|---|---|
| Boiling point | 370.1±31.0 °C(Predicted) |
| Density | 1.155±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder to crystal |
| pka | 16.40±0.20(Predicted) |
| color | White to Almost white |
| InChI | 1S/C10H18N2O3/c1-10(2,3)15-9(14)12-5-4-7(6-12)8(11)13/h7H,4-6H2,1-3H3,(H2,11,13) |
| InChIKey | NHDGOVOBEZPXMY-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCC(C1)C(N)=O |
| CAS DataBase Reference | 122684-34-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
3-Aminocarbonyl-1-Boc-pyrrolidine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000051 | 3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester Aldrich | 122684-34-8 | 1g | $230 | 2026-04-30 | Buy |
| TCI Chemical | B5248 | tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N) | 122684-34-8 | 1g | $95 | 2026-04-30 | Buy |
| TCI Chemical | B5248 | tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N) | 122684-34-8 | 5g | $284 | 2026-04-30 | Buy |
| Apolloscientific | OR321355 | tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98% | 122684-34-8 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR321355 | tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98% | 122684-34-8 | 1g | $28 | 2026-06-04 | Buy |
3-Aminocarbonyl-1-Boc-pyrrolidine Chemical Properties, Uses, Production
Uses
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate is used for preparation and sulfuration of 1,2,4-thiadiazoles.
Synthesis
72925-16-7
122684-34-8
The general procedure for the synthesis of 1-BOC-pyrrolidine-3-carboxamide from (R)-1-Boc-3-carboxypyrrolidine was as follows: to a solution of 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (5 g, 23.23 mmol) in anhydrous THF (100 mL) was added triethylamine (TEA, 4.69 g, 46.46 mmol) and isobutyl chloroformic acid ester (3.8 g, 27.87 mmol). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, ammonia (NH3-H2O) was slowly added and stirring was continued for 2 h at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and washed sequentially with saturated sodium carbonate solution (2 × 20 mL) and saturated sodium bicarbonate solution. The organic layer was then washed with citric acid solution (2 × 20 mL) to remove residual base. Finally, the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (2.39 g, 49% yield) as a yellow solid. Mass spectrometry (ESI) analysis showed: m/z = 159.0 [M + H]+.
References
[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 91
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
[3] Chemical Biology and Drug Design, 2016, p. 54 - 65
3-Aminocarbonyl-1-Boc-pyrrolidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Beijing HengPuGao Pharmaceutical Chemistry Technology Co., Ltd. | 010-81520996 13439320863 | hengpugao@126.com | China | 159 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Latest Price from 3-Aminocarbonyl-1-Boc-pyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP
122684-34-8
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-08-12 | 3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-04-28 | 3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
|
1KG | 99.0% | 500 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP
122684-34-8
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- 3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
