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3-Aminocarbonyl-1-Boc-pyrrolidine

3-Aminocarbonyl-1-Boc-pyrrolidine structure

CAS No.: 122684-34-8

Chemical Name:: 3-Aminocarbonyl-1-Boc-pyrrolidine

Synonyms: TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE;1-Boc-3-pyrrolidinecarboxamide;1-BOC-PYRROLIDINE-3-CARBOXAMIDE;1-BOC-PYRROLIDINE-3-CARBOXYAMIDE;3-AMINOCARBONYL-1-BOC-PYRROLIDINE;(S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE;3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP;1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide;TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

CBNumber:: CB1205707

Molecular Formula:: C10H18N2O3

Molecular Weight:: 214.26

MDL Number:: MFCD04116210

MOL File:: 122684-34-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:14:33

Product description	Number	Pack Size	Price
3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester Aldrich	ADE000051	1g	$230
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N)	B5248	1g	$95
tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N)	B5248	5g	$284
tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98%	OR321355	250mg	$21
tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98%	OR321355	1g	$28
More product size

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3-Aminocarbonyl-1-Boc-pyrrolidine Properties

Melting point	117.0 to 121.0 °C
Boiling point	370.1±31.0 °C(Predicted)
Density	1.155±0.06 g/cm3(Predicted)
storage temp.	2-8°C
form	powder to crystal
pka	16.40±0.20(Predicted)
color	White to Almost white
InChI	1S/C10H18N2O3/c1-10(2,3)15-9(14)12-5-4-7(6-12)8(11)13/h7H,4-6H2,1-3H3,(H2,11,13)
InChIKey	NHDGOVOBEZPXMY-UHFFFAOYSA-N
SMILES	CC(C)(C)OC(=O)N1CCC(C1)C(N)=O
CAS DataBase Reference	122684-34-8(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

WGK Germany

HazardClass

IRRITANT

HS Code

2933998090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	1
0		0

3-Aminocarbonyl-1-Boc-pyrrolidine price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000051	3-Carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester Aldrich	122684-34-8	1g	$230	2026-04-30	Buy
TCI Chemical	B5248	tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N)	122684-34-8	1g	$95	2026-04-30	Buy
TCI Chemical	B5248	tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate >98.0%(HPLC)(N)	122684-34-8	5g	$284	2026-04-30	Buy
Apolloscientific	OR321355	tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98%	122684-34-8	250mg	$21	2026-06-04	Buy
Apolloscientific	OR321355	tert-Butyl 3-carbamoylpyrrolidine-1-carboxylate >98%	122684-34-8	1g	$28	2026-06-04	Buy

Product number	Packaging	Price	Buy
ADE000051	1g	$230	Buy
B5248	1g	$95	Buy
B5248	5g	$284	Buy
OR321355	250mg	$21	Buy
OR321355	1g	$28	Buy

3-Aminocarbonyl-1-Boc-pyrrolidine Chemical Properties,Uses,Production

Uses

tert-Butyl 3-Carbamoylpyrrolidine-1-carboxylate is used for preparation and sulfuration of 1,2,4-thiadiazoles.

Synthesis

72925-16-7

122684-34-8

The general procedure for the synthesis of 1-BOC-pyrrolidine-3-carboxamide from (R)-1-Boc-3-carboxypyrrolidine was as follows: to a solution of 1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (5 g, 23.23 mmol) in anhydrous THF (100 mL) was added triethylamine (TEA, 4.69 g, 46.46 mmol) and isobutyl chloroformic acid ester (3.8 g, 27.87 mmol). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, ammonia (NH3-H2O) was slowly added and stirring was continued for 2 h at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and washed sequentially with saturated sodium carbonate solution (2 × 20 mL) and saturated sodium bicarbonate solution. The organic layer was then washed with citric acid solution (2 × 20 mL) to remove residual base. Finally, the organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product (2.39 g, 49% yield) as a yellow solid. Mass spectrometry (ESI) analysis showed: m/z = 159.0 [M + H]+.

References

[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 91
[2] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059
[3] Chemical Biology and Drug Design, 2016, p. 54 - 65

3-Aminocarbonyl-1-Boc-pyrrolidine Preparation Products And Raw materials

Raw materials

(R)-1-N-Boc-beta-proline Isobutyl chloroformate Tetrahydrofuran Ammonia Water

Triethylamine

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Preparation Products

1-N-Boc-3-Cyanopyrrolidine

3-Aminocarbonyl-1-Boc-pyrrolidine Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20792	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 3-Aminocarbonyl-1-Boc-pyrrolidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP 122684-34-8	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2021-08-12	3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2020-04-28	3-Aminocarbonyl-1-Boc-pyrrolidine 122684-34-8		1KG	99.0%	500 tons	Shaanxi Dideu Medichem Co. Ltd

3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP
122684-34-8
$1.10
99.9%
Dideu Industries Group Limited

3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-Aminocarbonyl-1-Boc-pyrrolidine
122684-34-8
99.0%
Shaanxi Dideu Medichem Co. Ltd

3-Aminocarbonyl-1-Boc-pyrrolidine Spectrum

3-Aminocarbonyl-1-Boc-pyrrolidine(122684-34-8)¹HNMR

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3-CARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-AMINOCARBONYL-1-BOC-PYRROLIDINE (S)-1-BOC-PYRROLIDINE-3-CARBOXAMIDE 1-BOC-PYRROLIDINE-3-CARBOXAMIDE TERT-BUTYL 3-(AMINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE 1-BOC-PYRROLIDINE-3-CARBOXYAMIDE N-[2-oxo-3-(trifluoromethyl)-3-piperidinyl]carbamic acid tert-butyl ester 1-Pyrrolidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester 1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxamide 1-Boc-3-pyrrolidinecarboxamide 3-Aminocarbonyl-1-Boc-pyrrolidine USP/EP/BP TERT-BUTYL 3-CARBAMOYLPYRROLIDINE-1-CARBOXYLATE 122684-34-8 123751 pharmacetical