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4,4-Difluorocyclohexanol

4,4-Difluorocyclohexanol Structure
4,4-Difluorocyclohexanol structure
CAS No.
22419-35-8
Chemical Name:
4,4-Difluorocyclohexanol
Synonyms
4,4-difluorocyclohexanol;Cyclohexanol, 4,4-difluoro-;4,4-Difluorocyclohexanol;1,1-Difluoro-4-hydroxycyclohexane
CBNumber:
CB12123210
Molecular Formula:
C6H10F2O
Molecular Weight:
136.14
MDL Number:
MFCD10000566
MOL File:
22419-35-8.mol
MSDS File:
SDS
Last updated:2025-09-29 22:33:22
Product description Number Pack Size Price
4,4-Difluorocyclohexanol 95% 740748 500mg $125
4,4-Difluorocyclohexanol >98.0%(GC) D5540 200mg $40
4,4-Difluorocyclohexanol >98.0%(GC) D5540 1g $134
4,​4-​Difluorocyclohexanol D442370 2.5g $250
4,4-difluorocyclohexan-1-ol FD104442 2g $280
More product size
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4,4-Difluorocyclohexanol Properties

Melting point 60-65°C
Boiling point 160.6±40.0 °C(Predicted)
Density 1.15±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 14.14±0.40(Predicted)
form powder to lump
color White to Orange to Green
InChI InChI=1S/C6H10F2O/c7-6(8)3-1-5(9)2-4-6/h5,9H,1-4H2
InChIKey XTJZBCBHCPQASK-UHFFFAOYSA-N
SMILES C1(O)CCC(F)(F)CC1
CAS DataBase Reference 22419-35-8
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
HS Code  2906120000
NFPA 704
0
2 0

4,4-Difluorocyclohexanol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 740748 4,4-Difluorocyclohexanol 95% 22419-35-8 500mg $125 2023-06-20 Buy
TCI Chemical D5540 4,4-Difluorocyclohexanol >98.0%(GC) 22419-35-8 200mg $40 2025-07-31 Buy
TCI Chemical D5540 4,4-Difluorocyclohexanol >98.0%(GC) 22419-35-8 1g $134 2025-07-31 Buy
TRC D442370 4,​4-​Difluorocyclohexanol 22419-35-8 2.5g $250 2021-12-16 Buy
Biosynth Carbosynth FD104442 4,4-difluorocyclohexan-1-ol 22419-35-8 2g $280 2021-12-16 Buy
Product number Packaging Price Buy
740748 500mg $125 Buy
D5540 200mg $40 Buy
D5540 1g $134 Buy
D442370 2.5g $250 Buy
FD104442 2g $280 Buy

4,4-Difluorocyclohexanol Chemical Properties,Uses,Production

Chemical Properties

viscous liquid

Uses

4,?4-?Difluorocyclohexanol is a reagent used in the clearance of adenosine inhibitors of bacterial NAD+-dependent DNA ligase.

Synthesis

4,4-DIFLUOROCYCLOHEXANONE

22515-18-0

4,4-Difluorocyclohexanol

22419-35-8

General procedure for the synthesis of 4,4-difluorocyclohexanol from 4,4-difluorocyclohexanone: Sodium borohydride (460 mg, 12.17 mmol) was added to a cold solution of 4,4-difluorocyclohexanone (907 mg, 6.76 mmol) in methanol (22 mL) under the conditions of an ice water bath. The reaction mixture was stirred for 5 minutes and then allowed to warm slowly to room temperature and continued stirring for 1 hour. Upon completion of the reaction, the reaction was quenched with water (11 mL) and stirred for 30 minutes. Subsequently, the solvent was removed by concentration on a rotary evaporator and the residue was partitioned between water (11 mL) and dichloromethane (10 mL). The aqueous layer was separated and extracted with dichloromethane (3 x 10 mL). All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and the solvent was concentrated to give the target product 4,4-difluorocyclohexanol (839 mg, 91% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.03-3.82 (m, 1H), 2.26-1.98 (m, 2H), 1.98-1.64 (m, 6H), 1.43 (d, J = 3.6 Hz, 1H).

References

[1] Patent: WO2015/164520, 2015, A1. Location in patent: Page/Page column 63
[2] Patent: WO2016/196776, 2016, A2. Location in patent: Paragraph 001239
[3] Patent: EP2213675, 2010, A1. Location in patent: Page/Page column 41
[4] Patent: US2015/94328, 2015, A1. Location in patent: Paragraph 0427-0429
[5] Patent: WO2015/49574, 2015, A1. Location in patent: Page/Page column 49; 50

4,4-Difluorocyclohexanol Preparation Products And Raw materials

Raw materials

4,4-DIFLUOROCYCLOHEXANONE CASPASE-1

Preparation Products

4,4-Difluorocyclohexanol Suppliers

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403; info@fortunachem.com China 5997 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16516 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 933 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88299272 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Supplier Advantage
Wuhan Fortuna Chemical Co., Ltd 		58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
HaBo Hong Kong Co., Limited. 		58
Accela ChemBio Inc. 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from 4,4-Difluorocyclohexanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4-Difluorocyclohexanol pictures 2025-10-17 4,4-Difluorocyclohexanol
22419-35-8
 US $0.00 / G 1G 98%min 30kg/month WUHAN FORTUNA CHEMICAL CO., LTD
4,4-Difluorocyclohexanol pictures 2025-10-13 4,4-Difluorocyclohexanol
22419-35-8
 US $2.20-8.80 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
4,4-Difluorocyclohexanol pictures 2025-04-04 4,4-Difluorocyclohexanol
22419-35-8
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

4,4-Difluorocyclohexanol Spectrum

4,4-Difluorocyclohexanol(22419-35-8)1HNMR4,4-Difluorocyclohexanol(22419-35-8)FT-IR

22419-35-8(4,4-Difluorocyclohexanol)Related Search:

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4,4-difluorocyclohexanol 1,1-Difluoro-4-hydroxycyclohexane Cyclohexanol, 4,4-difluoro- 4,4-Difluorocyclohexanol 22419-35-8