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ChemicalBook >> CAS DataBase List >>4,4-DIFLUOROCYCLOHEXANONE

4,4-DIFLUOROCYCLOHEXANONE

4,4-DIFLUOROCYCLOHEXANONE Structure
4,4-DIFLUOROCYCLOHEXANONE structure
CAS No.
22515-18-0
Chemical Name:
4,4-DIFLUOROCYCLOHEXANONE
Synonyms
4,4-Difluorocyclohexan-1-one;uorocycL;4,4-DIFLUOROCYCLOHEXANONE;4,4-difluro-cyclohexanone;Cyclohexanone, 4,4-difluoro-;4,4-Difluorocyclohexanone;1,1,-Difluoro-4-oxocyclohexane;4,4-Difluorocyclohexanone(WX900093);TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE
CBNumber:
CB5149175
Molecular Formula:
C6H8F2O
Molecular Weight:
134.12
MDL Number:
MFCD08146635
MOL File:
22515-18-0.mol
MSDS File:
SDS
Last updated:2026-05-28 02:02:06
Product description Number Pack Size Price
4,4-Difluorocyclohexanone 97% 711403 250mg $214
4,4-Difluorocyclohexanone min. 98.0 % D4516 1G $34
4,4-Difluorocyclohexanone min. 98.0 % D4516 5G $111
4,4-Difluorocyclohexanone 433492 1g $403
4,4-Difluorocyclohexanone 433492 10g $1776
More product size
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4,4-DIFLUOROCYCLOHEXANONE Properties

Melting point 35-36°C
Boiling point 157.4±40.0 °C(Predicted)
Density 1.14g/ml
Flash point 65°C
storage temp. Sealed in dry,Store in freezer, under -20°C
form low melting solid
Appearance white solid
Water Solubility Insoluble in water.
InChI InChI=1S/C6H8F2O/c7-6(8)3-1-5(9)2-4-6/h1-4H2
InChIKey NYYSPVRERVXMLJ-UHFFFAOYSA-N
SMILES C1(=O)CCC(F)(F)CC1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37
WGK Germany  3
HazardClass  IRRITANT
HS Code  29147000
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4,4-DIFLUOROCYCLOHEXANONE price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 711403 4,4-Difluorocyclohexanone 97% 22515-18-0 250mg $214 2026-04-30 Buy
TCI Chemical D4516 4,4-Difluorocyclohexanone min. 98.0 % 22515-18-0 1G $34 2026-04-30 Buy
TCI Chemical D4516 4,4-Difluorocyclohexanone min. 98.0 % 22515-18-0 5G $111 2026-04-30 Buy
Usbiological 433492 4,4-Difluorocyclohexanone 22515-18-0 1g $403 2026-06-03 Buy
Usbiological 433492 4,4-Difluorocyclohexanone 22515-18-0 10g $1776 2026-06-03 Buy
Product number Packaging Price Buy
711403 250mg $214 Buy
D4516 1G $34 Buy
D4516 5G $111 Buy
433492 1g $403 Buy
433492 10g $1776 Buy

4,4-DIFLUOROCYCLOHEXANONE Chemical Properties,Uses,Production

Chemical Properties

White to brown solid

Uses

4,4-Difluorocyclohexanone is used as a pharmaceutical intermediate.

Synthesis

8,8-difluoro-1,4-dioxaspiro[4.5]decane

176251-49-3

4,4-DIFLUOROCYCLOHEXANONE

22515-18-0

4.3. Synthesis of 4,4-difluorocyclohexanone (8): the acetonide 7 (20.0 g, 112.2 mmol) was suspended in 20% HCl aqueous solution (16 mL) and stirred vigorously for 3 hours at 100 °C. After the reaction was completed, it was cooled to room temperature and NaCl (~3 g) was added to the aqueous phase to dissolve it. Subsequently, the aqueous phase was extracted with CH2Cl2 (3 x 50 mL). The organic phases were combined, washed with 50 mL of water, dried over Na2SO4, and the solvent was slowly evaporated under reduced pressure at 20 °C. Due to the extreme instability of the product, the material initially obtained was a 1:1 mixture of product 8 and raw material 5. After repeating the above operation, the ratio of 8 to 5 in the mixture was increased to 7:3. After a number of repetitions, the final product 8 was obtained with 95% purity as white crystals (11.0 g, 71% yield) with a melting point of 31-32°C. The product was then dried over 50 mL of water and evaporated slowly at 20°C under reduced pressure.

References

[1] Organic Letters, 2013, vol. 15, # 5, p. 1088 - 1091
[2] Tetrahedron, 2013, vol. 69, # 20, p. 4066 - 4075
[3] Patent: US2006/293392, 2006, A1. Location in patent: Page/Page column 51
[4] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 28
[5] Patent: WO2009/48547, 2009, A1. Location in patent: Page/Page column 40

4,4-DIFLUOROCYCLOHEXANONE synthesis

176251-49-3
22515-18-0
Synthesis of 4,4-DIFLUOROCYCLOHEXANONE from 8,8-difluoro-1,4-dioxaspiro[4.5]decane

4,4-DIFLUOROCYCLOHEXANONE Preparation Products And Raw materials

Raw materials

8,8-difluoro-1,4-dioxaspiro[4.5]decane 4,4-difluoroheptanedioic acid diethyl ester DIETHYL 4-OXOPIMELATE Hydrochloric acid 3-(2-Furyl)acrylic acid
1,4-Dioxaspiro[4.5]decan-8-one

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Preparation Products

(4,4-difluorocyclohexyl)methanamine 2-(4,4-Difluorocyclohex-1-en-1-yl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane AC 186 Acetic acid, 2-(4,4-difluorocyclohexylidene)-, ethyl ester Ethyl 5,5-difluoro-2-oxo-cyclohexanecarboxylate

4,4-DIFLUOROCYCLOHEXANONE Suppliers

Global( 252)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14035 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21533 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2984 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 17389186172 1077@dideu.com China 3999 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Finetech Industry Limited 		+86-27-8746-5837 +86-18627785180 info@finetechnology-ind.com China 9539 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Finetech Industry Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 4,4-DIFLUOROCYCLOHEXANONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4-DIFLUOROCYCLOHEXANONE pictures 2025-04-04 4,4-DIFLUOROCYCLOHEXANONE
22515-18-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4,4-Difluorocyclohexan-1-one pictures 2024-02-26 4,4-Difluorocyclohexan-1-one
22515-18-0
 1kg 98% BTC Nantong Pharmaceuticals Technology Co.,Ltd
4,4-DIFLUOROCYCLOHEXANONE pictures 2019-08-09 4,4-DIFLUOROCYCLOHEXANONE
22515-18-0
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

4,4-DIFLUOROCYCLOHEXANONE Spectrum

4,4-DIFLUOROCYCLOHEXANONE(22515-18-0)1HNMR

22515-18-0(4,4-DIFLUOROCYCLOHEXANONE)Related Search:

4,4-Difluorocyclohexanol 4,4-DIFLUOROPIPERIDINE 4,4-DIFLUOROCYCLOHEXYLAMINE HYDROCHLORIDE 3,3-DIFLUOROPYRROLIDINE HYDROCHLORIDE 2,2-Difluoropropionic acid
Ethyl 2,2-Difluoropropionate 4,4-Difluoropiperidine hydrochloride 4,4-DIFLUOROCYCLOHEXANONE

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4,4-DIFLUOROCYCLOHEXANONE 1,1,-Difluoro-4-oxocyclohexane 4,4-difluro-cyclohexanone 4,4-Difluorocyclohexanone Cyclohexanone, 4,4-difluoro- 4,4-Difluorocyclohexanone(WX900093) uorocycL TIANFU CHEM --4,4-DIFLUOROCYCLOHEXANONE 4,4-Difluorocyclohexan-1-one 22515-18-0 22525-18-0 C6H8F2O Alkyl Fluorinated Building Blocks Building Blocks C3 to C6 Carbonyl Compounds Chemical Synthesis Fluorinated Building Blocks Ketones Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks