Eperisone hydrochloride
- CAS No.
- 56839-43-1
- Chemical Name:
- Eperisone hydrochloride
- Synonyms
- EPERISONE HCL;Eperison Hydrochloride;1-(4-Ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride;empp;e-646;e0646;myonal;mional;Atines;Akitonal
- CBNumber:
- CB1772111
- Molecular Formula:
- C17H26ClNO
- Molecular Weight:
- 295.85
- MDL Number:
- MFCD00941459
- MOL File:
- 56839-43-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-171°C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| InChI | InChI=1S/C17H25NO.ClH/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18;/h7-10,14H,3-6,11-13H2,1-2H3;1H |
| InChIKey | GTAXGNCCEYZRII-UHFFFAOYSA-N |
| SMILES | C1(=CC=C(CC)C=C1)C(=O)C(C)CN1CCCCC1.Cl |
| CAS DataBase Reference | 56839-43-1(CAS DataBase Reference) |
| FDA UNII | U38O8U7P6X |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in male S.D. rats, Wistar rats, mice (mg/kg): 1300, 1850, 1024 orally (Miyagawa) |
Eperisone hydrochloride price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FE22701 | Eperisone hydrochloride | 56839-43-1 | 10g | $172.8 | 2026-06-04 | Buy |
| Biosynth | FE22701 | Eperisone hydrochloride | 56839-43-1 | 25g | $345.5 | 2026-06-04 | Buy |
| Biosynth | FE22701 | Eperisone hydrochloride | 56839-43-1 | 50g | $518 | 2026-06-04 | Buy |
| Biosynth | FE22701 | Eperisone hydrochloride | 56839-43-1 | 100g | $691 | 2026-06-04 | Buy |
| Biosynth | FE22701 | Eperisone hydrochloride | 56839-43-1 | 250g | $865 | 2026-06-04 | Buy |
Eperisone hydrochloride Chemical Properties, Uses, Production
Synthesis
The product was synthesized by reacting p-ethylphenylacetone (2) with guanethidine hydrochloride via the Mannieh reaction, as shown in Figure 1:
Figure 1 shows the reaction route for the synthesis of ethylperisone hydrochloride
Synthesis method:
1. Synthesis of p-ethylphenylacetone (2)
Propyl chloride (100g, 1.08 mol) was added. After treatment, the reaction solution was distilled under reduced pressure after recovering petroleum ether and excess ethylbenzene. The fraction at bP112-114 ℃/1.33kPa was collected to obtain 2.
2. Synthesis of ethylparaben (1)
Take freshly distilled ethylparaben (20.2 g, 0.24 mol), add anhydrous ethanol (20 ml), add concentrated hydrochloric acid dropwise at low temperature to pH 4-5, evaporate the ethanol under reduced pressure, then add anhydrous ethanol (50 ml), p-ethyl acetone (32.4 g, 0.2 mol), 36% formaldehyde solution (42.0 g, 0.5 mol) and concentrated hydrochloric acid (1 ml), stir and reflux for 8 h, evaporate the solvent, dissolve the residue in 10% sodium hydroxide solution, extract with ether, wash the extract with water, dry, and pass hydrogen chloride through in an ice-water bath to pH 2-3. Filter out the generated solid, recrystallize with ethanol-acetone to obtain 1 colorless crystal.
Description
Eperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cervical spondylosis and cerebral palsy. It is structurally related to tolperisone.
Chemical Properties
White Solid
Originator
Eisai (Japan)
Uses
Used as antispasmodic
Uses
A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).
Application
Clinically, eperisone hydrochloride is widely used to treat various symptoms of muscle tension. For instance, in orthopedics, it is frequently employed to alleviate pain and muscle tension resulting from fractures, dislocations, and muscle strains; in neurology, it is used to treat muscle rigidity and spasms associated with conditions such as Parkinson's disease and multiple sclerosis; and in rehabilitation medicine, it helps improve the recovery of muscle function following sports injuries.
Definition
ChEBI: Eperisone hydrochloride is an aromatic ketone.
Manufacturing Process
To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.
brand name
MYONAL
Therapeutic Function
Muscle relaxant
Mechanism of action
Eperisone hydrochloride treats symptoms of hypertonia by acting on the central nervous system to relax skeletal muscles and directly relax vascular smooth muscle. It primarily affects spinal reflexes and gamma motor neurons, effectively inhibiting spinal reflexes and muscle sensitivity, while simultaneously increasing blood circulation and suppressing pain reflexes. Chemicalbook is a multi-point muscle relaxant, acting on the vicious cycle of muscle rigidity (hypertonia → insufficient blood supply → pain → further increase in muscle tension) to relieve symptoms of hypertonia. Its key feature is the simultaneous relaxation of high-tension muscles, improved blood circulation, and reduction of accompanying pain.
Eperisone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU YOUHELIN PHARMTECH CO.LTD | 18268150871; 17302275155 | tanglulu11129@163.com | China | 28 | 58 |
| Tianjin Maitian Technology Co., Ltd | 19102267946 | motitech@126.com | China | 96 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from Eperisone hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Eperisone hydrochloride
56839-43-1
|
1KG | 98.5%-101.0% | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-18 | Eperisone hydrochloride
56839-43-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-18 | Eperisone Hydrochloride
56839-43-1
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Eperisone hydrochloride
56839-43-1
- $0.00
- 98.5%-101.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Eperisone hydrochloride
56839-43-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Eperisone Hydrochloride
56839-43-1
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
