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Ethyl pyrazole-4-carboxylate

Ethyl pyrazole-4-carboxylate Structure
Ethyl pyrazole-4-carboxylate structure
CAS No.
37622-90-5
Chemical Name:
Ethyl pyrazole-4-carboxylate
Synonyms
Ethyl 1H-pyrazole-4-carboxylate;ETHYL 4-PYRAZOLECARBOXYLATE;1H-Pyrazole-4-carboxylic acid ethyl ester;4-Pyrazolecarboxylic Acid Ethyl Ester;ecarboxyL;4-PyrazoL;Regadenoson Impurity 7;Regadenoson impurity C;4- pyrazoleethyl forMate;4-Ethoxycarbonylpyrazole
CBNumber:
CB1294747
Molecular Formula:
C6H8N2O2
Molecular Weight:
140.14
MDL Number:
MFCD00010844
MOL File:
37622-90-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:30:56
Request For Quotation

Ethyl pyrazole-4-carboxylate Properties

Melting point 78-80 °C (lit.)
Boiling point 138-140 °C/3 mmHg (lit.)
Density 1.2850 (rough estimate)
refractive index 1.5010 (estimate)
Flash point 138-140°C/3mm
storage temp. Sealed in dry,Room Temperature
solubility Miscible with acetone.
form Crystalline Powder
pka 11.70±0.50(Predicted)
color White to pale yellow
InChI InChI=1S/C6H8N2O2/c1-2-10-6(9)5-3-7-8-4-5/h3-4H,2H2,1H3,(H,7,8)
InChIKey KACZQOKEFKFNDB-UHFFFAOYSA-N
SMILES N1C=C(C(OCC)=O)C=N1
LogP 0.909 (est)
CAS DataBase Reference 37622-90-5(CAS DataBase Reference)
NIST Chemistry Reference 4-(C2H5COO)-pyrazole(37622-90-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29331990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Ethyl pyrazole-4-carboxylate price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 300780 Ethyl 4-pyrazolecarboxylate 99% 37622-90-5 500mg $24 2023-01-07 Buy
TCI Chemical E0871 Ethyl 4-Pyrazolecarboxylate >98.0%(GC) 37622-90-5 1g $30 2026-04-30 Buy
TCI Chemical E0871 Ethyl 4-Pyrazolecarboxylate >98.0%(GC) 37622-90-5 5g $86 2026-04-30 Buy
Usbiological 274793 Ethyl pyrazole-4-carboxylate Asreported 37622-90-5 5g $333 2026-06-03 Buy
Usbiological 274793 Ethyl pyrazole-4-carboxylate Asreported 37622-90-5 10g $453 2026-06-03 Buy
Product number Packaging Price Buy
300780 500mg $24 Buy
E0871 1g $30 Buy
E0871 5g $86 Buy
274793 5g $333 Buy
274793 10g $453 Buy

Ethyl pyrazole-4-carboxylate Chemical Properties,Uses,Production

Chemical Properties

White to pale yellow crystalline powder

Uses

Ethyl pyrazole-4-carboxylate is used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides.

Uses

Used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides as herbicides.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 30, p. 865, 1993 DOI: 10.1002/jhet.5570300404

Synthesis

Propanoicacid,2-formyl-3-oxo-,ethylester

80370-42-9

Ethyl pyrazole-4-carboxylate

37622-90-5

The general procedure for the synthesis of ethyl 4-pyrazolecarboxylate from ethyl 2-formyl-3-oxopropanoate was as follows: 6.2 g (193 mmol) of hydrazine was slowly added to a solution of 27.6 g (192 mmol) of (ethoxycarbonyl)malondialdehyde dissolved in 150 mL of ethanol under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 17 hours to complete the reaction. Subsequently, ethanol was removed from the reaction mixture by vacuum distillation. The residue was purified by silica gel column chromatography using a solvent mixture of dichloromethane and ethyl acetate as the unfolding agent, resulting in 19.4 g (72.4% yield) of ethyl 1H-pyrazole-4-carboxylate as yellow crystals.1H-NMR [CDCl3/TMS, δ (ppm)]: 8.08 (2H, s), 5.30 (1H, s), 4.31 ( 2H, q), 1.36 (3H, t).

References

[1] Tetrahedron, 2008, vol. 64, # 33, p. 7745 - 7758
[2] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 4, p. 865 - 872
[3] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 196
[4] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 32

Ethyl pyrazole-4-carboxylate synthesis

37718-11-9
64-17-5
37622-90-5
Synthesis of Ethyl pyrazole-4-carboxylate from 4-Pyrazolecarboxylic acid and Ethanol

Ethyl pyrazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Propanoicacid,2-formyl-3-oxo-,ethylester Ethyl 3-amino-4-pyrazolecarboxylate HYDRAZINE Ethanol

Preparation Products

1H-Pyrazole-4-carboxaldehyde N-Methylpyrazole-4-carboxaMide (1H-Pyrazol-4-yl)methanol 1-tert-butyl 4-ethyl 1H-pyrazole-1,4-dicarboxylate 1-(Pyridin-4-ylmethyl)-1H-pyrazole-4-carboxylic acid
1H-Pyrazole-4-carboxylic acid

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Ethyl pyrazole-4-carboxylate Suppliers

Global( 403)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Ucheml Medicine Co., Ltd. 0519-86058959 13775231161 sales@uchemi.cn China 301 50
JiangYin Ruisheng Chemical Co., Ltd. 13003356808 1485751188@qq.com China 403 55
Nanijing m&m biotechnology Co. ,Ltd. 025-87782433 18021532344 1345332203@qq.com China 4226 58
Shanghai Micro-Mega Industry Co., Ltd. 021-34628682 18918069061 sales@micro-megaindustry.com China 95 55
Changzhou hanergy Biotechnology Co., Ltd 13915872857 hannengchemical@163.com China 117 58
Changzhou chennuo Biotechnology Co., Ltd 17768395970 35015765@qq.com China 46 58
Changzhou Standard Chemicals Ltd. 0519-85607885 13776800733 email@standardschem.com China 118 62
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Changzhou Ucheml Medicine Co., Ltd. 50
JiangYin Ruisheng Chemical Co., Ltd. 55
Nanijing m&m biotechnology Co. ,Ltd. 58
Shanghai Micro-Mega Industry Co., Ltd. 55
Changzhou hanergy Biotechnology Co., Ltd 58
Changzhou chennuo Biotechnology Co., Ltd 58
Changzhou Standard Chemicals Ltd. 62
Creasyn Finechem(Tianjin) Co., Ltd. 68
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

View Lastest Price from Ethyl pyrazole-4-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl pyrazole-4-carboxylate pictures 2023-06-17 Ethyl pyrazole-4-carboxylate
37622-90-5
 $1.00 25KG 99.0% 3000KG/th Zibo Shiji Zhonglian Medical Technology Co., Ltd.
Ethyl 4-pyrazolecarboxylate pictures 2021-10-21 Ethyl 4-pyrazolecarboxylate
37622-90-5
 $10.00 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
Ethyl pyrazole-4-carboxylate pictures 2021-08-12 Ethyl pyrazole-4-carboxylate
37622-90-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

Ethyl pyrazole-4-carboxylate Spectrum

Ethyl pyrazole-4-carboxylate(37622-90-5)1HNMREthyl pyrazole-4-carboxylate(37622-90-5)RamanEthyl pyrazole-4-carboxylate(37622-90-5)IREthyl pyrazole-4-carboxylate(37622-90-5)FT-IR

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