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Ethyl 3-amino-4-pyrazolecarboxylate

Ethyl 3-amino-4-pyrazolecarboxylate Structure
Ethyl 3-amino-4-pyrazolecarboxylate structure
CAS No.
6994-25-8
Chemical Name:
Ethyl 3-amino-4-pyrazolecarboxylate
Synonyms
ETHYL 5-AMINO-1H-PYRAZOLE-4-CARBOXYLATE;Ethyl 3-amino-1H-pyrazole-4-carboxylate;3-AMINO-4-CARBETHOXYPYRAZOLE;Allopurinol Related Compound D;5-Amino-1H-pyrazole-4-carboxylic acid;3-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;AMINAZOLE;INDIP-014;AKOS B001005;AKOS BC-0708
CBNumber:
CB7371660
Molecular Formula:
C6H9N3O2
Molecular Weight:
155.15
MDL Number:
MFCD00005238
MOL File:
6994-25-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:48:08
Request For Quotation

Ethyl 3-amino-4-pyrazolecarboxylate Properties

Melting point 105-107 °C(lit.)
Boiling point 278.95°C (rough estimate)
Density 1.3092 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 12.98±0.50(Predicted)
form Crystalline Powder
color White to yellow
BRN 4964
Stability Light sensitive
InChI InChI=1S/C6H9N3O2/c1-2-11-6(10)4-3-8-9-5(4)7/h3H,2H2,1H3,(H3,7,8,9)
InChIKey YPXGHKWOJXQLQU-UHFFFAOYSA-N
SMILES N1C=C(C(OCC)=O)C(N)=N1
CAS DataBase Reference 6994-25-8(CAS DataBase Reference)
FDA UNII 9GY5HA1GAA
NIST Chemistry Reference 3-Amino-4-carbethoxypyrazole(6994-25-8)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn,N
Risk Statements  36/37/38-20/21/22-50/53-43
Safety Statements  26-36-24/25-61-60-36/37
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HazardClass  IRRITANT
HS Code  29331990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
REACH Registrations Active
NFPA 704
0
1 0

Ethyl 3-amino-4-pyrazolecarboxylate price More Price(104)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich BP844 Allopurinol impurity D British Pharmacopoeia (BP) Reference Standard 6994-25-8 10MG $266 2026-04-30 Buy
Sigma-Aldrich A45009 Ethyl 3-aminopyrazole-4-carboxylate 98% 6994-25-8 5g $37.3 2026-04-30 Buy
Sigma-Aldrich A0350040 Allopurinol impurity D European Pharmacopoeia (EP) Reference Standard 6994-25-8 15 mg $167 2026-04-30 Buy
Sigma-Aldrich 1013046 Allopurinol Related Compound D United States Pharmacopeia (USP) Reference Standard 6994-25-8 35mg $1290 2026-04-30 Buy
TCI Chemical E0766 Ethyl 3-Aminopyrazole-4-carboxylate >98.0%(GC)(T) 6994-25-8 5g $71 2026-04-30 Buy
Product number Packaging Price Buy
BP844 10MG $266 Buy
A45009 5g $37.3 Buy
A0350040 15 mg $167 Buy
1013046 35mg $1290 Buy
E0766 5g $71 Buy

Ethyl 3-amino-4-pyrazolecarboxylate Chemical Properties, Uses, Production

Chemical Properties

Off-White Powder

Uses

Ethyl 3-Amino-4-pyrazolecarboxylate (Allopurinol EP Impurity D) is an impurity of Allopurinol (A547300), a pyrazole derivative that has been shown to induce neoplasm immunogenicity.

Application

Ethyl 3-amino-4-pyrazolecarboxylate is a pyrazole organic compound containing an amino group and an ethoxycarbonyl group. It can be used as a ligand in the synthesis of metal coordination compounds.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Synthesis

Ethyl (ethoxymethylene)cyanoacetate

94-05-3

Ethyl 5-aMino-1H-pyrazole-4-carboxylate

1260243-04-6

General procedure for the synthesis of ethyl 5-amino-1H-pyrazole-4-carboxylate from ethyl ethoxymethylcyanoacetate: ethyl ethoxymethylcyanoacetate (68 g, 0.4 mol) was added to a reaction vessel containing 200 mL of anhydrous ethanol; 100 mL of hydrazine hydrate was added slowly and dropwise to the reaction vessel. The reaction mixture was placed in an electric heating jacket and gradually heated up to 80 °C within 30 min to obtain mixture A. The mixture A was heated to reflux and kept in reflux reaction for 4 h. The reaction was carried out under reduced pressure. Upon completion of the reaction, ethanol was removed by distillation under reduced pressure and the remaining solid was concentrated by evaporation. The concentrated solid was cooled to room temperature and left to precipitate a light yellow solid, which was filtered, washed and dried to give the intermediate ethyl 5-amino-1H-pyrazole-4-carboxylate. Cold anhydrous ethanol was used for the washing process. The mass of the final product ethyl 5-amino-1H-pyrazole-4-carboxylate was 41.68 g and the yield was 66.78%.

References

[1] Patent: CN105949202, 2016, A. Location in patent: Paragraph 0048-0053
[2] Patent: CN106008517, 2016, A. Location in patent: Paragraph 0048; 0049; 0050; 0051; 0052; 0053
[3] Patent: CN106008519, 2016, A. Location in patent: Paragraph 0048; 0049; 0050; 0051; 0052; 0053
[4] Patent: CN105949199, 2016, A. Location in patent: Paragraph 0047-0052
[5] Patent: CN105949200, 2016, A. Location in patent: Page/Page column 6; 7; 23

Ethyl 3-amino-4-pyrazolecarboxylate synthesis

144918-37-6
6994-25-8
Synthesis of Ethyl 3-amino-4-pyrazolecarboxylate from 2-Pentenoic acid, 2-cyano-, ethyl ester, (2E)-

Ethyl 3-amino-4-pyrazolecarboxylate Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Triethyl orthoformate HYDRAZINE Acetic acid Ethyl (ethoxymethylene)cyanoacetate
Ethyl cyanoacetate N,N-Dimethylformamide dimethyl acetal Propanoic acid, 2-cyano-3-ethoxy-, ethyl ester 2-Propenoic acid, 2-cyano-3-methoxy-, ethyl ester, (2Z)- Ethanol

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Preparation Products

Allopurinol Ethyl 5,7-dichloropyrazolo[1,5-A]pyrimidine-3-carboxylate 1-H-pyrazole-4-carboxylic acid,3-broMo,ethyl ester 5-Amino-4-carbethoxy-1-phenylpyrazole ethyl 5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate
1H-Pyrazole-4-carboxylic acid, 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-, ethyl ester Ethyl 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Ethyl 3-amino-4-pyrazolecarboxylate Suppliers

Global Suppliers ( 501)
Supplier Tel Email Country ProdList Advantage
Changzhou hanergy Biotechnology Co., Ltd 13915872857 hannengchemical@163.com China 117 58
Shanghai Xiannuo Biotechnology Co., Ltd. 021-50718719 13918719472 China 978 58
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1341 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375880 15098789112 3845379039@qq.com China 1457 58
Hubei Deli Pharmaceutical Technology Co., Ltd 13372285931 19237964946 dl@delipharm.com China 107 58
XianTao Li Zhao 18571672902 1010771219@qq.com China 362 58
Changzhou Ucheml Medicine Co., Ltd. 0519-86058959 13775231161 sales@uchemi.cn China 301 50
Changzhou chennuo Biotechnology Co., Ltd 17768395970 35015765@qq.com China 46 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Changzhou hanergy Biotechnology Co., Ltd 58
Shanghai Xiannuo Biotechnology Co., Ltd. 58
Shanghai Taijilin Industrial Co., Ltd. 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
Hubei Deli Pharmaceutical Technology Co., Ltd 58
XianTao Li Zhao 58
Changzhou Ucheml Medicine Co., Ltd. 50
Changzhou chennuo Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

View Latest Price from Ethyl 3-amino-4-pyrazolecarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 3-amino-4-pyrazolecarboxylate pictures 2026-06-30 Ethyl 3-amino-4-pyrazolecarboxylate
6994-25-8
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
Ethyl 3-amino-4-pyrazolecarboxylate pictures 2026-02-02 Ethyl 3-amino-4-pyrazolecarboxylate
6994-25-8
 1g 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
Ethyl 3-amino-4-pyrazolecarboxylate pictures 2022-02-25 Ethyl 3-amino-4-pyrazolecarboxylate
6994-25-8
 $100.00 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd

Ethyl 3-amino-4-pyrazolecarboxylate Spectrum

Ethyl 3-amino-4-pyrazolecarboxylate(6994-25-8)1HNMREthyl 3-amino-4-pyrazolecarboxylate(6994-25-8)13CNMREthyl 3-amino-4-pyrazolecarboxylate(6994-25-8)IR1Ethyl 3-amino-4-pyrazolecarboxylate(6994-25-8)IR2Ethyl 3-amino-4-pyrazolecarboxylate(6994-25-8)Raman

6994-25-8 (Ethyl 3-amino-4-pyrazolecarboxylate) Related Search:

ethyl 5-(forMylaMino)-1H-pyrazole-4-carboxylate 5-(forMylaMino)-1H-pyrazole-4-carboxaMide 3-Aminopyrazole 4-Pyrazolecarboxylic acid 3-Aminopyrazole-4-carboxylic acid
Ethyl pyrazole-4-carboxylate 5-Amino-1H-pyrazole-4-carboxylic acid ethyl ester Oxypurinol -13C, 15N2 Oxipurinol Allopurinol Impurity 1
Allopurinol Related CoMpound F Allopurinol-d2 Allopurinol Allopurinol riboside 3-Amino-1H-pyrazole-4-carboxamide
Allopurinol impurity C 4-Amino-2 H-pyrazole-3-carboxylic acid ethyl ester 5-[(1-Methylpiperidin-2-ylidene)amino]-1H-pyrazole-4-carboxylic acid ethyl ester

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JR-8260, 3-Amino-4-carbethoxypyrazole, 97% Ethyl 5-amino-1H-pyrazole-4-carboxylate 97% Allopurinol EP Impurity D (USP RC D) Allopurinol EP IMpurity D 3- aMino-4- pyrazoleethyl forMate 5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(Ethyl 3-amino-4-pyrazolecarboxylate) Ethyl3-amino-1H-pyrazole-4-carboxylate,99% AKOS BC-0708 AKOS BBS-00002579 AMINAZOLE AKOS B001005 5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-AMINO-4-CARBETHOXYPYRAZOL 3-AMINOPYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 1H-PYRAZOLE-4-CARBOXYLIC ACID, 3-AMINO-, ETHYL ESTER ETHYL 3-AMINOPYRAZOLE-4-CARBOXYLATE ETHYL 3-AMINO-4-PYRAZOLECARBOXYLATE BUTTPARK 100\09-33 3-Amino-4-ethoxycarbonylpyrazole TIMTEC-BB SBB001936 Ethyl 3-amino-4-pyarazolecarboxylate 3-Amino-4-pyrazolecarboxylate 3-Amino-4-(ethoxycarbonyl)-1H-pyrazole, 3-Amino-4-carbethoxy-1H-pyrazole Ethyl 5-aminopyrazol-4-carboxylate INDIP-014 Allopurinol Impurity 4(Allopurinol EP Impurity D)(Allopurinol USP Related Compound D ) Ethyl 3-aminopyrazole-4-carboxylate 98% 3-amino-2H-pyrazole-4-carboxylic acid ethyl ester Allopurinol Related Compound D 3-Amino-4-Carbethyloxypyrazole 5-Amino-1H-pyrazole-4-carboxylic acid ethyl 3-amino-2H-pyrazole-4-carboxylate Ethyl 3-amino-4-pyrazolecarboxylate ,99% 3-AMINO-4-CARBETHOXYPYRAZOLE ,99% ethyl 5-amino-1H-pyrazole-4-carboxylate(SALTDATA: FREE) ethyl 3-amino-1H-pyrazole-4-carboxylate(SALTDATA: FREE) 3-Amino-4-carboethoxy-1H-pyrazole Ethyl 2-aminopyrazole-3-carboxylate Allopurinol Related Compound D (35 mg) (ethyl 5-amino-1H-pyrazole-4-carboxylate) 4-(ethoxyMethyl)-1H-pyrazol-3-aMine 3-AMino-4-carbethoxypyrazole, 99% 5GR 1H-pyrazole-4-carboxylic acid, 5-amino-, ethyl ester ETHYL (3-AMINOPYRAZOLE 4-CARBOXYLATE) FO Allopurinol EP Imp D Allopurinol EP Impurity D or Allopurinol USP Related Compound D Allopurinol EP Impurity D（Allopurinol USP Related Compound D） e-4-carboxyL Ethyl 3-Amino-4-pyrazolecarboxylate > Allopurinol impurity D CRS Ethyl-3-amino-1H-pyrazol-4-carboxylat Allopurinol EP impurity D/ Allopurinol Related Compound D Allopurinol Impurity1580 Allopurinol impurity D (A0350040) Allopurinol Related Compound D (ethyl 5-amino-1H-pyrazole-4-carboxylate) (1013046) Allopurinol USP Related Compound D thyl 3-amino-4-pyrazolecarboxylate d .?e th yl 5-a mi no-1h -pyra zole -4-c a rb oxyla te , Ethyl 3-amino-1H-pyrazol-4-carboxylate