1-(Cbz-amino)cyclopropanecarboxylic acid
- CAS No.
- 84677-06-5
- Chemical Name:
- 1-(Cbz-amino)cyclopropanecarboxylic acid
- Synonyms
- Z-ACPC-OH;Z-AC3C-OH;Cbz-ACPC-OH;1-(Z-amino)cycL;1-(z-amino)cyclopropanecarboxylic acid;Z-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(Cbz-amino)cyclopropanecarboxylic acid;N-Cbz-1-aMinocyclopropanecarboxylic acid;CBZ-1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID;1-(N-CBZ-AMINO)CYCLO-PROPANECARBOXYLIC ACID
- CBNumber:
- CB1349236
- Molecular Formula:
- C12H13NO4
- Molecular Weight:
- 235.24
- MDL Number:
- MFCD00083285
- MOL File:
- 84677-06-5.mol
- MSDS File:
- SDS
| Melting point | 157.0 to 161.0 °C |
|---|---|
| Boiling point | 449.0±34.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 4.02±0.20(Predicted) |
| color | White to Almost white |
| InChI | 1S/C12H13NO4/c14-10(15)12(6-7-12)13-11(16)17-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,13,16)(H,14,15) |
| InChIKey | KHINKCGJKZSHAJ-UHFFFAOYSA-N |
| SMILES | OC(=O)C1(CC1)NC(=O)OCc2ccccc2 |
| CAS DataBase Reference | 84677-06-5(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 2924297099 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
1-(Cbz-amino)cyclopropanecarboxylic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7047 | 1-(Z-amino)cyclopropanecarboxylic acid | 84677-06-5 | 500mg | $458 | 2026-04-30 | Buy |
| TCI Chemical | C2680 | 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid >98.0%(HPLC)(T) | 84677-06-5 | 1g | $35 | 2026-04-30 | Buy |
| TCI Chemical | C2680 | 1-(Carbobenzoxyamino)cyclopropanecarboxylic Acid >98.0%(HPLC)(T) | 84677-06-5 | 5g | $140 | 2026-04-30 | Buy |
| Usbiological | 261303 | Z-1-aminocyclopropane-1-carboxylic acid Asreported | 84677-06-5 | 2g | $345 | 2026-06-03 | Buy |
| Usbiological | 261303 | Z-1-aminocyclopropane-1-carboxylic acid Asreported | 84677-06-5 | 5g | $516 | 2026-06-03 | Buy |
1-(Cbz-amino)cyclopropanecarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White powder
Uses
1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic Acid is a useful intermediate used in the preparation of the analogs of vasopressins and other peptide derivatives.
Synthesis
13139-17-8
22059-21-8
84677-06-5
Step A: Synthesis of intermediate VI A tetrahydrofuran (THF, 500 mL) solution of benzyl 2,5-dioxopyrrolidin-1-yl carbonate (83 g, 334 mmol) was added slowly and dropwise to an aqueous (500 mL) solution of 1-aminocyclopropanecarboxylic acid (25 g, 247 mmol). A solution of sodium bicarbonate (91 g, 1088 mmol) in water (500 mL) was added dropwise to the reaction mixture under cooling in an ice bath. After the dropwise addition, the reaction system was slowly warmed to room temperature and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was resuspended in dichloromethane (200 mL) and extracted with water (500 mL). The aqueous phase was acidified by acetic acid and the precipitated white solid was collected by filtration to afford 1-((benzyloxy)carbonyl)amino)cyclopropanecarboxylic acid (53 g, 171 mmol, 69.2% yield). The crude product can be directly used in the next step of the reaction.LC/MS analysis result: m/z calculated value 235.1, measured value 258.0 ([M+Na]+).
References
[1] Synlett, 2004, # 14, p. 2489 - 2492
[2] Patent: WO2013/20245, 2013, A1. Location in patent: Paragraph 00105
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 220; 221
1-(Cbz-amino)cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from 1-(Cbz-amino)cyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic acid
84677-06-5
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 1-(Cbz-amino)cyclopropanecarboxylic acid USP/EP/BP
84677-06-5
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-08-12 | 1-(Cbz-amino)cyclopropanecarboxylic acid
84677-06-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic acid
84677-06-5
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 1-(Cbz-amino)cyclopropanecarboxylic acid USP/EP/BP
84677-06-5
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- 1-(Cbz-amino)cyclopropanecarboxylic acid
84677-06-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
