5-Thio-D-glucose
- CAS No.
- 20408-97-3
- Chemical Name:
- 5-Thio-D-glucose
- Synonyms
- THIOGLUCOSE;d-glucos;NSC 204984;5-Thioglucose;5-Thio-D-glucose;GLUCOTHIOPYRANOSE;D-Glucose, 5-thio-;5-Thio-D-glucose ,98%;α-D-Glucothiopyranose;5-Thio-α-D-glucopyranose
- CBNumber:
- CB1358757
- Molecular Formula:
- C6H12O5S
- Molecular Weight:
- 196.22
- MDL Number:
- MFCD00148892
- MOL File:
- 20408-97-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 135-138 °C(lit.) |
|---|---|
| Boiling point | 303.11°C (rough estimate) |
| Density | 1.271 (estimate) |
| refractive index | 1.5060 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in Water (up to 15 mg/ml) |
| form | Powder |
| pka | 9.11±0.10(Predicted) |
| color | White |
| optical activity | [α]/D 220.0±5.0°, c = 1 in 0.1 M HCl |
| Water Solubility | Miscible with water. |
| Merck | 13,9408 |
| BRN | 1865193 |
| Stability | Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. |
| InChI | 1S/C6H12O5S/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1 |
| InChIKey | KNWYARBAEIMVMZ-DVKNGEFBSA-N |
| SMILES | OC[C@H]1S[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O |
| CAS DataBase Reference | 20408-97-3 |
| FDA UNII | 3PRV1384UO |
| EPA Substance Registry System | D-Glucose, 5-thio- (20408-97-3) |
| UNSPSC Code | 12352201 |
| NACRES | NA.25 |
5-Thio-D-glucose price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 88635 | 5-Thio-D-glucose ≥98.0% (HPLC) | 20408-97-3 | 1g | $1920 | 2026-04-30 | Buy |
| Biosynth | MT04882 | 5-Thio-D-glucose | 20408-97-3 | 50mg | $317 | 2026-06-04 | Buy |
| Biosynth | MT04882 | 5-Thio-D-glucose | 20408-97-3 | 100mg | $548 | 2026-06-04 | Buy |
| Biosynth | MT04882 | 5-Thio-D-glucose | 20408-97-3 | 250mg | $865 | 2026-06-04 | Buy |
| Biosynth | MT04882 | 5-Thio-D-glucose | 20408-97-3 | 500mg | $1300 | 2026-06-04 | Buy |
5-Thio-D-glucose Chemical Properties, Uses, Production
Description
5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3 Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4 Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5
Uses
5-Thio-D-glucose (cas# 20408-97-3) is a compound useful in organic synthesis.
References
[1] Z WANG H G. Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose.[J]. Experimental and Clinical Endocrinology & Diabetes, 1995, 103 Suppl 2: 83-97. DOI:10.1055/s-0029-1211400
[2] MAITREYEE SHAH. Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus.[J]. American journal of physiology. Endocrinology and metabolism, 2019, 316 5: E948-E955. DOI:10.1152/ajpendo.00468.2018
[3] AI-JUN LI. Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons.[J]. American journal of physiology. Regulatory, integrative and comparative physiology, 2014, 306 4: R257-64. DOI:10.1152/ajpregu.00451.2013
[4] MELITA SALKOVIC-PETRISIC. Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway[J]. Journal of Neurochemistry, 2006, 96 4: 1005-1015. DOI:10.1111/j.1471-4159.2005.03637.x
[5] LANE P. 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozocine diabetes in rats.[J]. Endocrinology, 2000, 26 1: 3337-3342. DOI:10.1210/en.141.9.3337
5-Thio-D-glucose Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Feiyang Biotechnology Co., Ltd | 0533-7866336 13573361699 | sales@chemfy.com | China | 524 | 62 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Nanjing Asian Chemical Co., Ltd. | +86 (25) 82263158 | China | 262 | 60 | |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Latest Price from 5-Thio-D-glucose manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | 5-Thio-D-glucose
20408-97-3
|
10G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2019-07-06 | 5-THIO-D-GLUCOSE
20408-97-3
|
$1.00 | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- 5-Thio-D-glucose
20408-97-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-THIO-D-GLUCOSE
20408-97-3
- $1.00
- 98%
- Career Henan Chemical Co
