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Z-Phg-OH

Z-Phg-OH structure

CAS No.: 53990-33-3

Chemical Name:: Z-Phg-OH

Synonyms: Z-Phg;Cbz-Phg;Z-Phg-OH;CBZ-PHG-OH;Z-L-Phg-OH;Cbz-L-Phg-OH;N-CBZ-L-Phg-OH;Z-PHENYLGLYCINE;Z-(PHENYL)GLY-OH;Z-L-PHENYLGLYCINE

CBNumber:: CB1306132

Molecular Formula:: C16H15NO4

Molecular Weight:: 285.3

MDL Number:: MFCD00077033

MOL File:: 53990-33-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:10

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Z-Phg-OH Properties

Melting point	131.0 to 135.0 °C
Boiling point	495.3±45.0 °C(Predicted)
Density	1.275±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly)
form	Solid
pka	3.49±0.10(Predicted)
color	White
BRN	4703006
Major Application	peptide synthesis
InChI	InChI=1/C16H15NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1-10,14H,11H2,(H,17,20)(H,18,19)/t14-/s3
InChIKey	RLDJWBVOZVJJOS-WDHUHKLTNA-N
SMILES	[C@H](C1C=CC=CC=1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 \|&1:0,r\|
CAS DataBase Reference	53990-33-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
HS Code	29242990
Storage Class	11 - Combustible Solids

Z-Phg-OH price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	72517	Z-Phg-OH ≥99.0% (HPLC)	53990-33-3	5G	$187	2026-04-30	Buy
TCI Chemical	C2567	N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	53990-33-3	1g	$17	2026-04-30	Buy
TCI Chemical	C2567	N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	53990-33-3	5g	$36	2026-04-30	Buy
Usbiological	469003	Z-L-Phenylglycine	53990-33-3	5g	$305	2026-06-03	Buy
Usbiological	469003	Z-L-Phenylglycine	53990-33-3	10g	$389	2026-06-03	Buy

Product number	Packaging	Price	Buy
72517	5G	$187	Buy
C2567	1g	$17	Buy
C2567	5g	$36	Buy
469003	5g	$305	Buy
469003	10g	$389	Buy

Z-Phg-OH Chemical Properties, Uses, Production

Chemical Properties

White to off-white powder

Uses

Z-L-Phenylglycine is an intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2935-35-5

501-53-1

2-([(benzyloxy)carbonyl]amino)-2-phenylacetic acid

5491-18-9

General procedure for the synthesis of the compound (CAS:5491-18-9) from L-phenylglycine and benzyl chloroformate: To an aqueous solution (500 mL) containing 2-amino-2-phenylacetic acid (20 g, 0.12 mol), sodium carbonate (27.97 g, 0.264 mol) and sodium bicarbonate (11.1 g, 0.132 mol) were added at room temperature. The mixture was stirred until a clarified solution was formed. Acetone (40 mL) was then added and the resulting slightly turbid solution was cooled to 15-20 °C in an ice water bath. Benzyl chloroformate (Cbz-Cl, 28.15 g, 0.165 mol) was added slowly with stirring and then the reaction mixture was gradually warmed to room temperature. After continued stirring for 3 h, the reaction mixture was extracted with methyl tert-butyl ether (100 mL). The pH of the aqueous layer was adjusted with aqueous hydrochloric acid to 2. The oil formed was extracted with ethyl acetate (100 mL x 2). The organic layers were combined, washed with water and concentrated under vacuum to give (S)-2-(((benzyloxy)carbonyl)amino)-2-phenylacetic acid (30.2 g, 80% yield) as a white solid.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[2] Patent: WO2018/136647, 2018, A2. Location in patent: Page/Page column 29-30
[3] Tetrahedron Letters, 1993, vol. 34, # 39, p. 6329 - 6332
[4] Patent: WO2014/210436, 2014, A2. Location in patent: Paragraph 00520; 00521
[5] Patent: EP1076563, 2005, B1. Location in patent: Page/Page column 9; 13

Z-Phg-OH Preparation Products And Raw materials

Raw materials

Benzeneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (αS)- L-Phenylglycine Benzyl chloroformate Sodium bicarbonate Sodium carbonate

Acetone

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Preparation Products

Z-Phg-OH Suppliers

Global Suppliers ( 259)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Yangzhou Aoxin Chemical Co., Ltd	0514-87754778 13901446058	sales@aochem.com	China	69	66
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Yangzhou Aoxin Chemical Co., Ltd	66
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Latest Price from Z-Phg-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	Z-PHG-OH 53990-33-3		10g	99%min	10000G	WUHAN FORTUNA CHEMICAL CO., LTD
2025-05-23	Z-Phg-OH 53990-33-3	$50.00	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co Ltd
2021-08-12	Z-PHG-OH 53990-33-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Z-PHG-OH
53990-33-3
$0.00
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Z-Phg-OH
53990-33-3
$50.00
99
Hebei Zhuanglai Chemical Trading Co Ltd

Z-PHG-OH
53990-33-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

53990-33-3 (Z-Phg-OH) Related Search:

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BOC-N-ME-PHG-OH 4-Hydroxy-L-phenylglycine 2-Amino-2-phenylacetic acid

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N-ALPHA-CARBOBENZOXY-L-PHENYLGLYCINE N-ALPHA-CBZ-L-PHENYLGLYCINE N-CBZ-L-PHENYLGLYCINE Z-(PHENYL)GLY-OH Z-PHENYLGLYCINE Z-L-PHENYLGLYCINE CBZ-PHG-OH CBZ-L-PHENYLGLYCINE BENZYLOXYCARBONYL-L-PHENYLGLYCINE (2S)-2-{[(benzyloxy)carbonyl]amino}-2-phenylacetic acid (S)-N-Cbz-2-amino-2-phenylacetic Acid Cbz-L-Alpha-Phenylglycine N-CBZ-L-PHENYLGLYCINE (Z-PHG-OH) N-CBZ-L-PHENYLGLYCINE(CBZ-PHG-OH) NALPHA-Benzyloxycarbonyl-L-phenylglycine BENZYLOXYCARBONYL-L-PHENYLGLYCINE(N-CBZ-L-PHENYLGLYCINE) Z-L-Phg-OH N-Carbobenzyloxy-L-phenylglycine (S)-2-(benzyloxycarbonylamino)-2-phenylaceticacid N-Carbobenzoxy-L-2-phenylglycine Z-L-2-phenylglycine Z-Phg-OH N-Benzyloxycarbonyl-L-phenylglycine, 98% Z-Phg N-CBZ-L-Phg-OH Cbz-L-Phg-OH N-Carbobenzoxy-L-2-phenylglycine N-CBz-phenylglycine Z-L-phenylglycine≥ 99% (HPLC) N-Cbz-L-phenylglycine,99%e.e. N-Carbobenzoxy-L-2-phenylglycine > (2S)-2-phenyl-2-(phenylmethoxycarbonylamino)acetic acid Z-Phg-OH Z-L-Phenylglycine Benzeneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, (αS)- Asimadoline Impurity 3 (2S)-2-phenyl-2-(phenylmethoxycarbonylamino)aceticaci N-Benzyloxycarbonyl-L-2-phenylglycine Z-L-2-phenylglycine Z-PHG-OH USP/EP/BP Z-L-Phenylglycine, 98%+ Z-L-Phenylglycine extrapure, 99% (S)-2-(N-CBZ-Amino)-2-phenyl-acetic acid N-Benzyloxycarbonyl-L-phenylglycine Cbz-Phg Z-Phg-OH 53990-33-3 CARBOXYLIC ACID Phenylglycine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Phenylglycine [Phg]