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Z-PHG-OH

Z-PHG-OH structure

CAS No.: 53990-33-3

Chemical Name:: Z-PHG-OH

Synonyms: Z-Phg;Z-PHG-OH;CBZ-PHG-OH;Z-L-Phg-OH;Cbz-L-Phg-OH;N-CBZ-L-Phg-OH;Z-PHENYLGLYCINE;Z-(PHENYL)GLY-OH;Z-L-PHENYLGLYCINE;Z-PHG-OH USP/EP/BP

CBNumber:: CB1306132

Molecular Formula:: C16H15NO4

Molecular Weight:: 285.3

MDL Number:: MFCD00077033

MOL File:: 53990-33-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

Product description	Number	Pack Size	Price
Z-Phg-OH ≥99.0% (HPLC)	72517	5G	$175
N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	C2567	1g	$21
N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	C2567	5g	$52
Z-L-Phenylglycine	P327305	25g	$60
Z-L-Phenylglycine	P327305	50g	$80
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Z-PHG-OH Properties

Melting point	131.0 to 135.0 °C
Boiling point	495.3±45.0 °C(Predicted)
Density	1.275±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly)
pka	3.49±0.10(Predicted)
form	Solid
color	White
BRN	4703006
InChI	InChI=1/C16H15NO4/c18-15(19)14(13-9-5-2-6-10-13)17-16(20)21-11-12-7-3-1-4-8-12/h1-10,14H,11H2,(H,17,20)(H,18,19)/t14-/s3
InChIKey	RLDJWBVOZVJJOS-WDHUHKLTNA-N
SMILES	[C@H](C1C=CC=CC=1)(C(=O)O)NC(=O)OCC1C=CC=CC=1 \|&1:0,r\|
CAS DataBase Reference	53990-33-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	29242990

Z-PHG-OH price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	72517	Z-Phg-OH ≥99.0% (HPLC)	53990-33-3	5G	$175	2025-07-31	Buy
TCI Chemical	C2567	N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	53990-33-3	1g	$21	2025-07-31	Buy
TCI Chemical	C2567	N-Carbobenzoxy-L-2-phenylglycine >98.0%(HPLC)(T)	53990-33-3	5g	$52	2025-07-31	Buy
TRC	P327305	Z-L-Phenylglycine	53990-33-3	25g	$60	2021-12-16	Buy
TRC	P327305	Z-L-Phenylglycine	53990-33-3	50g	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
72517	5G	$175	Buy
C2567	1g	$21	Buy
C2567	5g	$52	Buy
P327305	25g	$60	Buy
P327305	50g	$80	Buy

Z-PHG-OH Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

Z-L-Phenylglycine is an intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2935-35-5

501-53-1

2-([(benzyloxy)carbonyl]amino)-2-phenylacetic acid

5491-18-9

General procedure for the synthesis of the compound (CAS:5491-18-9) from L-phenylglycine and benzyl chloroformate: To an aqueous solution (500 mL) containing 2-amino-2-phenylacetic acid (20 g, 0.12 mol), sodium carbonate (27.97 g, 0.264 mol) and sodium bicarbonate (11.1 g, 0.132 mol) were added at room temperature. The mixture was stirred until a clarified solution was formed. Acetone (40 mL) was then added and the resulting slightly turbid solution was cooled to 15-20 °C in an ice water bath. Benzyl chloroformate (Cbz-Cl, 28.15 g, 0.165 mol) was added slowly with stirring and then the reaction mixture was gradually warmed to room temperature. After continued stirring for 3 h, the reaction mixture was extracted with methyl tert-butyl ether (100 mL). The pH of the aqueous layer was adjusted with aqueous hydrochloric acid to 2. The oil formed was extracted with ethyl acetate (100 mL x 2). The organic layers were combined, washed with water and concentrated under vacuum to give (S)-2-(((benzyloxy)carbonyl)amino)-2-phenylacetic acid (30.2 g, 80% yield) as a white solid.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 36, p. 6393 - 6396
[2] Patent: WO2018/136647, 2018, A2. Location in patent: Page/Page column 29-30
[3] Tetrahedron Letters, 1993, vol. 34, # 39, p. 6329 - 6332
[4] Patent: WO2014/210436, 2014, A2. Location in patent: Paragraph 00520; 00521
[5] Patent: EP1076563, 2005, B1. Location in patent: Page/Page column 9; 13

Z-PHG-OH Preparation Products And Raw materials

Raw materials

Benzeneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (αS)- L-Phenylglycine Benzyl chloroformate Sodium bicarbonate Sodium carbonate

Acetone

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Preparation Products

Z-PHG-OH Suppliers

Global( 252)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29843	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49976	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Nanjing Fred Technology Co., Ltd.	+86-02584696168 15380713688	Austin@fredchem.cn	CHINA	865	58

Supplier	Advantage
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Nanjing Fred Technology Co., Ltd.	58

View Lastest Price from Z-PHG-OH manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-17	Z-PHG-OH 53990-33-3	US $0.00 / KG	10g	99%min	10000G	WUHAN FORTUNA CHEMICAL CO., LTD
2025-05-23	Z-Phg-OH 53990-33-3	US $50.00 / kg	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co Ltd
2021-08-12	Z-PHG-OH 53990-33-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Z-PHG-OH
53990-33-3
US $0.00 / KG
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Z-Phg-OH
53990-33-3
US $50.00 / kg
99
Hebei Zhuanglai Chemical Trading Co Ltd

Z-PHG-OH
53990-33-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

53990-33-3(Z-PHG-OH)Related Search:

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Cbz-L-Threonine benzyl ester Benzyl (2R,3S)-(1-carbamoyl-2-hydroxypropyl)carbamate Z-TRP-OSU Z-PRO-NH2 Z-PHG-OSU

FMOC-D-PHG-OH BOC-N-ME-PHG-OH H-DL-PHG-OH

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N-ALPHA-CARBOBENZOXY-L-PHENYLGLYCINE N-ALPHA-CBZ-L-PHENYLGLYCINE N-CBZ-L-PHENYLGLYCINE Z-(PHENYL)GLY-OH Z-PHENYLGLYCINE Z-L-PHENYLGLYCINE Z-PHG-OH CBZ-PHG-OH CBZ-L-PHENYLGLYCINE BENZYLOXYCARBONYL-L-PHENYLGLYCINE (2S)-2-{[(benzyloxy)carbonyl]amino}-2-phenylacetic acid (S)-N-Cbz-2-amino-2-phenylacetic Acid Cbz-L-Alpha-Phenylglycine N-CBZ-L-PHENYLGLYCINE (Z-PHG-OH) N-CBZ-L-PHENYLGLYCINE(CBZ-PHG-OH) NALPHA-Benzyloxycarbonyl-L-phenylglycine BENZYLOXYCARBONYL-L-PHENYLGLYCINE(N-CBZ-L-PHENYLGLYCINE) Z-L-Phg-OH N-Carbobenzyloxy-L-phenylglycine (S)-2-(benzyloxycarbonylamino)-2-phenylaceticacid N-Carbobenzoxy-L-2-phenylglycine Z-L-2-phenylglycine Z-Phg-OH N-Benzyloxycarbonyl-L-phenylglycine, 98% Z-Phg N-CBZ-L-Phg-OH Cbz-L-Phg-OH N-Carbobenzoxy-L-2-phenylglycine N-CBz-phenylglycine Z-L-phenylglycine≥ 99% (HPLC) N-Cbz-L-phenylglycine,99%e.e. N-Carbobenzoxy-L-2-phenylglycine > (2S)-2-phenyl-2-(phenylmethoxycarbonylamino)acetic acid Z-Phg-OH Z-L-Phenylglycine Benzeneacetic acid, α-[[(phenylmethoxy)carbonyl]amino]-, (αS)- Asimadoline Impurity 3 (2S)-2-phenyl-2-(phenylmethoxycarbonylamino)aceticaci N-Benzyloxycarbonyl-L-2-phenylglycine Z-L-2-phenylglycine Z-PHG-OH USP/EP/BP Z-L-Phenylglycine, 98%+ Z-L-Phenylglycine extrapure, 99% (S)-2-(N-CBZ-Amino)-2-phenyl-acetic acid 53990-33-3 CARBOXYLIC ACID Phenylglycine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Phenylglycine [Phg]