ICILIN
- CAS No.
- 36945-98-9
- Chemical Name:
- ICILIN
- Synonyms
- AG-3-5;ICILIN;Iciline;CS-1406;ICILLIN;Icilin, >=98%;Icidin Ag-3-5;Icilin(AG 3-5);AG 3-5; AG-3-5;Icilin - Bio-X ?
- CBNumber:
- CB1439247
- Molecular Formula:
- C16H13N3O4
- Molecular Weight:
- 311.29
- MDL Number:
- MFCD01689072
- MOL File:
- 36945-98-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 594.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.415±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO: 15 mg/mL, soluble |
| form | solid |
| pka | 9.94±0.35(Predicted) |
| color | yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) |
| InChIKey | RCEFMOGVOYEGJN-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C2=CC=CC=C2O)CC=C(C2=CC=CC([N+]([O-])=O)=C2)N1 |
| FDA UNII | CS70PZQ4QJ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ICILIN price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I9532 | Icilin ≥97% (HPLC), solid | 36945-98-9 | 10MG | $199 | 2026-04-30 | Buy |
| Sigma-Aldrich | I9532 | Icilin ≥97% (HPLC), solid | 36945-98-9 | 50MG | $853 | 2026-04-30 | Buy |
| Cayman Chemical | 10137 | Icilin ≥98% | 36945-98-9 | 5mg | $55 | 2026-04-30 | Buy |
| Cayman Chemical | 10137 | Icilin ≥98% | 36945-98-9 | 10mg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 10137 | Icilin ≥98% | 36945-98-9 | 50mg | $414 | 2026-04-30 | Buy |
ICILIN Chemical Properties, Uses, Production
Description
Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50= 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50= 0.2 μM)2and ANKTM1(TRPA1)3. Activator effects require Ca2+and are pH dependent.2,4Icilin induced G1arrest in PC-3 prostate cancer cells without cell death.5
Uses
Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.
Definition
ChEBI: 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one is a C-nitro compound.
General Description
Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8) and modulates calcium release. Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).
Biological Activity
Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK-293 cells (EC 50 = 0.36 μ M) more potently than menthol or low temperatures. Produces "wet shakes" in vivo .
Biochem/physiol Actions
Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.
storage
Room temperature
References
[1] DAVID D. MCKEMY David J Werner M Neuhausser. Identification of a cold receptor reveals a general role for TRP channels in thermosensation[J]. Nature, 2002, 416 6876: 52-58. DOI:10.1038/nature719
[2] DAVID A ANDERSSON Stuart B Henry W N Chase. TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH.[J]. Journal of Neuroscience, 2004, 24 23: 5364-5369. DOI:10.1523/jneurosci.0890-04.2004
[3] GINA M STORY. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.[J]. Cell, 2003, 112 6: 819-829. DOI:10.1016/s0092-8674(03)00158-2
[4] HUAI-HU CHUANG David J Werner M Neuhausser. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel.[J]. Neuron, 2004, 43 6: 859-869. DOI:10.1016/j.neuron.2004.08.038
[5] SU-HWA KIM . Icilin induces G1 arrest through activating JNK and p38 kinase in a TRPM8-independent manner[J]. Biochemical and biophysical research communications, 2011, 406 1: Pages 30-35. DOI:10.1016/j.bbrc.2011.01.094
ICILIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973; 13621943973 | sales@jamxmpharmatech.com | China | 1191 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
View Latest Price from ICILIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | ICILIN
36945-98-9
|
$31.00-98.00 | 98.64% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Icilin
36945-98-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | Icilin
36945-98-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
