Esculetin
- CAS No.
- 305-01-1
- Chemical Name:
- Esculetin
- Synonyms
- 6,7-DIHYDROXYCOUMARIN;AESCULETIN;6,7-Dihydroxy-2H-chromen-2-one;Synonym;Esculetine;CICHORIGENIN;Esculeti;ESCULETIN;ESCULETOL;Nsc 26428
- CBNumber:
- CB1456020
- Molecular Formula:
- C9H6O4
- Molecular Weight:
- 178.14
- MDL Number:
- MFCD00006874
- MOL File:
- 305-01-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 271-273 °C(lit.) |
|---|---|
| Boiling point | 270.35°C (rough estimate) |
| Density | 1.3431 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | 2-8°C |
| solubility | Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid |
| form | powder |
| pka | 1.71(at 25℃) |
| color | Light yellow |
| PH Range | Weak blue uorescence (1.5) to strong blue uorescence (2.0) |
| Water Solubility | slightly soluble |
| Merck | 14,3697 |
| BRN | 152788 |
| Major Application | antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H |
| InChIKey | ILEDWLMCKZNDJK-UHFFFAOYSA-N |
| SMILES | Oc1cc2OC(=O)C=Cc2cc1O |
| LogP | 0.980 (est) |
| CAS DataBase Reference | 305-01-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | SM2XD6V944 |
| NIST Chemistry Reference | Coumarin, 6,7-dihydroxy-(305-01-1) |
| EPA Substance Registry System | Esculetin (305-01-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GN6382500 | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Esculetin price More Price(96)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001611 | Esculetin European Pharmacopoeia (EP) Reference Standard | 305-01-1 | 25 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | 246573 | 6,7-Dihydroxycoumarin 98% | 305-01-1 | 1g | $84.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL80449 | Esculetin phyproof® Reference Substance | 305-01-1 | 25 mg | $358 | 2026-04-30 | Buy |
| Sigma-Aldrich | 246573 | 6,7-Dihydroxycoumarin 98% | 305-01-1 | 5g | $375 | 2026-04-30 | Buy |
| TCI Chemical | E1287 | Esculetin [Matrix for MALDI-TOF/MS] >99.0%(HPLC)(T) | 305-01-1 | 200mg | $26 | 2026-04-30 | Buy |
Esculetin Chemical Properties, Uses, Production
Chemical Properties
YELLOWISH CRYSTALLINE POWDER
Uses
antifungal, hepatoprotective, IL-1 inhibitor
Uses
In filters for absorption of ultraviolet light.
Uses
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Definition
ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
General Description
Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.
Purification Methods
It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]
Esculetin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Nanjing bingcheng Biotechnology Co., Ltd. | 18805194892 | 2727751293@qq.com | China | 172 | 58 |
| Shaanxi Cuicheng Biomedical Technology Co., Ltd. | 18092486213 18891469960 | 524718246@qq.com | China | 143 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Esculetin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | Esculetin
305-01-1
|
$75.00-100.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-09-02 | Esculetin
305-01-1
|
$1.00-100.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-30 | Esculetin
305-01-1
|
$45.00 | 98.43% | 10g | TargetMol Chemicals Inc. |
305-01-1 (Esculetin) Related Search:
1of4
