7,8-Dihydroxy-6-methoxycoumarin
- CAS No.
- 574-84-5
- Chemical Name:
- 7,8-Dihydroxy-6-methoxycoumarin
- Synonyms
- FRAXETIN;Fraxetol;7,8-dihydroxy-6-methoxychromen-2-one;Fratexin;Fraccetain;Fraxetin-RM;Einecs 209-376-2;Fraxetin (Standard);Fraxetin (6-OMe, 7,8-OH);7,8-Dihydroxy-6-methoxycoumarin
- CBNumber:
- CB9110595
- Molecular Formula:
- C10H8O5
- Molecular Weight:
- 208.17
- MDL Number:
- MFCD00006873
- MOL File:
- 574-84-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 230-231 °C (lit.) |
|---|---|
| Boiling point | 307.35°C (rough estimate) |
| Density | 1.3844 (rough estimate) |
| refractive index | 1.4717 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic) |
| pka | 7.22±0.20(Predicted) |
| form | Solid |
| color | White |
| Merck | 13,4288 |
| Stability | Hygroscopic |
| Major Application | food and beverages |
| InChI | InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3 |
| InChIKey | HAVWRBANWNTOJX-UHFFFAOYSA-N |
| SMILES | C1(=O)OC2=C(O)C(O)=C(OC)C=C2C=C1 |
| LogP | 0.590 (est) |
| CAS DataBase Reference | 574-84-5(CAS DataBase Reference) |
| FDA UNII | CD3GD44O3K |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
7,8-Dihydroxy-6-methoxycoumarin price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 254916 | 7,8-Dihydroxy-6-methoxycoumarin 98% | 574-84-5 | 250mg | $537 | 2026-04-30 | Buy |
| Sigma-Aldrich | 18224 | Fraxetin analytical standard | 574-84-5 | 50mg | $248 | 2022-05-15 | Buy |
| Cayman Chemical | 28011 | Fraxetin ≥98% | 574-84-5 | 10mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 28011 | Fraxetin ≥98% | 574-84-5 | 25mg | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 28011 | Fraxetin ≥98% | 574-84-5 | 50mg | $263 | 2026-04-30 | Buy |
7,8-Dihydroxy-6-methoxycoumarin Chemical Properties,Uses,Production
Chemical Properties
Pale yellow crystalline powder, easily soluble in methanol and acetone, derived from the bark of Fraxinus chinensis, the bark of Fraxinus microphylla, and the leaves of Fraxinus himachicola.
Uses
Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.
Definition
ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.
in vivo
Fraxetin (20-50 mg/kg, gavage, once daily, 24 weeks) has a hepatoprotective effect in mice and also has antioxidant and anti-inflammatory activities[3].
| Animal Model: | Ethanol-induced liver fibrosis model in rats [3] |
| Dosage: | 20, 50 mg/kg; daily; 24 weeks |
| Administration: | i.g. |
| Result: | Reduced serum ALT and AST, weakened tissue pathological changes, upregulated heme oxygenase-1 (HO-1) protein, reduced lipid peroxidation, enhanced liver antioxidant capacity, inhibited CYP2E1 activity, and reduced inflammatory mediators such as TNF-α and IL-1β. |
7,8-Dihydroxy-6-methoxycoumarin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Bencao Yikang Biotechnology Co., Ltd | 025-69790911 18362932668 | 522593521@qq.com | China | 1163 | 58 |
| Nanjing bingcheng Biotechnology Co., Ltd. | 18805194892 | 2727751293@qq.com | China | 172 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
View Lastest Price from 7,8-Dihydroxy-6-methoxycoumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 7,8-DIHYDROXY-6-METHOXYCOUMARIN
574-84-5
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-02 | Fraxetin
574-84-5
|
$40.00-108.00 | 99.84% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Fraxetin
574-84-5
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- 7,8-DIHYDROXY-6-METHOXYCOUMARIN
574-84-5
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Fraxetin
574-84-5
- $40.00-108.00
- 99.84%
- TargetMol Chemicals Inc.
-
- Fraxetin
574-84-5
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
