5-Nitrouracil
- CAS No.
- 611-08-5
- Chemical Name:
- 5-Nitrouracil
- Synonyms
- 5-NITROPYRIMIDINE-2,4-DIOL;5-NITROPYRIMIDINE-2,4(1H,3H)-DIONE;NSC 9790;NITROURACIL;5-NITROURACIL;5-Nitrouyacil;5-Nitro-1H-pyr;Uracil, 5-nitro-;5-Nitrouracil>5-Nitrouracil 98%
- CBNumber:
- CB1457683
- Molecular Formula:
- C4H3N3O4
- Molecular Weight:
- 157.08
- MDL Number:
- MFCD00006021
- MOL File:
- 611-08-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Nitrouracil 98% | 852767 | 25g | $54.2 |
| 5-Nitrouracil >99.0%(HPLC)(T) | N0281 | 5g | $17 |
| 5-Nitrouracil >99.0%(HPLC)(T) | N0281 | 25g | $41 |
| 5-Nitrouracil | N2722 | 10g | $312 |
| 5-Nitrouracil | N2722 | 50g | $460 |
| More product size | |||
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 281.7°C (rough estimate) |
| Density | 1.8278 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Water |
| form | Crystalline Powder or Needles |
| pka | 5.19±0.10(Predicted) |
| color | Off-white to pale yellow |
| Water Solubility | 3.61g/L(25 ºC) |
| BRN | 10410 |
| InChI | InChI=1S/C4H3N3O4/c8-3-2(7(10)11)1-5-4(9)6-3/h1H,(H2,5,6,8,9) |
| InChIKey | TUARVSWVPPVUGS-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C([N+]([O-])=O)C(=O)N1 |
| CAS DataBase Reference | 611-08-5(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Nitrouracil (611-08-5) |
| UNSPSC Code | 12352103 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-34 | |||||||||
| Safety Statements | 22-24/25-45-36/37/39-26-16 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UV9104545 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| NFPA 704 |
|
5-Nitrouracil price More Price(99)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 852767 | 5-Nitrouracil 98% | 611-08-5 | 25g | $54.2 | 2023-06-20 | Buy |
| TCI Chemical | N0281 | 5-Nitrouracil >99.0%(HPLC)(T) | 611-08-5 | 5g | $17 | 2026-04-30 | Buy |
| TCI Chemical | N0281 | 5-Nitrouracil >99.0%(HPLC)(T) | 611-08-5 | 25g | $41 | 2026-04-30 | Buy |
| Usbiological | N2722 | 5-Nitrouracil | 611-08-5 | 10g | $312 | 2026-06-03 | Buy |
| Usbiological | N2722 | 5-Nitrouracil | 611-08-5 | 50g | $460 | 2026-06-03 | Buy |
5-Nitrouracil Chemical Properties,Uses,Production
Uses
5-Nitrouracil is a compound useful in organic synthesis.
Chemical Properties
Off-White Solid
Uses
5-Nitrouracil (cas# 611-08-5) is a compound useful in organic synthesis.
Definition
ChEBI: 5-nitrouracil is a C-nitro compound consisting of uracil having a nitro group at the 5-position. It is functionally related to a uracil.
Synthesis
66-22-8
611-08-5
The general procedure for the synthesis of 5-nitropyrimidine-2,4(1H,3H)-dione from pyrimidine-2,4(1H,3H)-dione: Nitric acid solution (5.34 mL, 120 mmol, 70% solution) was added drop-wise to concentrated sulfuric acid (19.7 mL, 360 mmol, 98% solution) under the condition of the temperature not exceeding 50 ℃. Subsequently, pyrimidine-2,4(1H,3H)-dione (7.204 g, 60 mmol) was added to the stirred mixed acid solution in batches while controlling the reaction temperature not to exceed 50°C. The reaction mixture was heated to 55 °C and maintained for 3 h, after which it was cooled below room temperature and the reaction was quenched with ice water (38 mL). The resulting white precipitate was collected by filtration, washed with a small amount of ice water and dried under reduced pressure at 55 °C to afford 5-nitropyrimidine-2,4(1H,3H)-dione (8.658 g, 55.11 mmol, 92% yield) as a white solid. Product properties: decomposition temperature >288°C; thin layer chromatography Rf value 0.00 (unfolding agent ratio 1:10 ethyl acetate/hexane); IR spectrum (ZnSe pool, solid) vmax: 3142-2811 cm^-1 (medium, broad, OH/NH/CH), 1732 cm^-1 (strong, C=O), 1677 and 1624 cm^-1 (strong. NO2), 1417 cm^-1 (medium, CH), 1356 cm^-1 (medium, NO2), 1318 cm^-1 (strong, aromatic R2NH/R3N), 1234 cm^-1 (strong, -OH), 975 and 832 cm^-1 (weak, aromatic ring bending); 1H NMR (500 MHz, d6-DMSO): δ 8.84 ( 1H, single peak, 6-CH) ppm; 13C NMR (125 MHz, d6-DMSO): δ 155.5 (4-C=O), 149.8 (6-CH), 147.9 (2-C=O), 125.1 (5-CNO2) ppm.
Purification Methods
The uracil recrystallises in prisms from boiling H2O as the monohydrate and loses H2O on drying in vacuo. [UV: Brown J Chem Soc 3647 1959, Brown J Appl Chem 2 239 1952, Johnson J Am Chem Soc 63 263 1941, Beilstein 24 I 313, 24 II 171, 24 III/IV 1236.]
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 29 - 34
[2] American Chemical Journal, 1905, vol. 33, p. 443
[3] American Chemical Journal, 1908, vol. 40, p. 31
[4] Journal of Biological Chemistry, 1908, vol. 4, p. 410
[5] Journal of the American Chemical Society, 1919, vol. 41, p. 786
5-Nitrouracil Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 | sales1@chuanghaibio.com | China | 5214 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
View Lastest Price from 5-Nitrouracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-02 | 5-Nitrouracil
611-08-5
|
$1.10-35.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 5-Nitrouracil
611-08-5
|
$10.70 | 10KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-04-10 | 5-Nitrouracil
611-08-5
|
$2.00-5.00 | 1KG | 99% hplc | 500TONS | Wuhan JiyunZen Tech Co., Ltd. |
-
- 5-Nitrouracil
611-08-5
- $1.10-35.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 5-Nitrouracil
611-08-5
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 5-Nitrouracil
611-08-5
- $2.00-5.00
- 99% hplc
- Wuhan JiyunZen Tech Co., Ltd.
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