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ChemicalBook >> CAS DataBase List >>2-CHLORO-5-NITROPYRIMIDIN-4-AMINE

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Structure
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE structure
CAS No.
1920-66-7
Chemical Name:
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
Synonyms
4-AMINO-2-CHLORO-5-NITROPYRIMIDINE;KML-51;IFLAB-BB F1930-0037;nitropyrimidin-​1-(2-prop-2-enoxyethoxy)butane;2-CHLORO-5-NITRO-4-PYRIMIDINAMINE;2-CHLORO-5-NITROPYRIMIDIN-4-AMINE;2-Chloro-5-nitropirimidin-4-amine;2-Chloro-5-nitropyrimidine-4-amine;2-Chloro-5-nitro-6-aminopyrimidine
CBNumber:
CB5468616
Molecular Formula:
C4H3ClN4O2
Molecular Weight:
174.55
MDL Number:
MFCD00127771
MOL File:
1920-66-7.mol
MSDS File:
SDS
Last updated:2026-05-28 01:57:01
Request For Quotation

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Properties

Melting point 221-226 °C
Boiling point 446.0±25.0 °C(Predicted)
Density 1.712±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -1.22±0.10(Predicted)
form Solid
Appearance Light yellow to yellow Solid
Water Solubility Slightly soluble in water.
InChI InChI=1S/C4H3ClN4O2/c5-4-7-1-2(9(10)11)3(6)8-4/h1H,(H2,6,7,8)
InChIKey RZGOEIWDMVQJBQ-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C([N+]([O-])=O)C(N)=N1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H315-H319-H334-H335
Precautionary statements  P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xn
Risk Statements  22-36/37/38-43
Safety Statements  26-36/37-36
WGK Germany  3
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 720321 4-Amino-2-chloro-5-nitropyrimidine 95% 1920-66-7 1g $211 2023-01-07 Buy
Sigma-Aldrich 720321 4-Amino-2-chloro-5-nitropyrimidine 95% 1920-66-7 250mg $74 2022-05-15 Buy
Apolloscientific OR471127 4-Amino-2-chloro-5-nitropyrimidine 96% 1920-66-7 250mg $21 2026-06-04 Buy
Apolloscientific OR471127 4-Amino-2-chloro-5-nitropyrimidine 96% 1920-66-7 1g $25 2026-06-04 Buy
Apolloscientific OR471127 4-Amino-2-chloro-5-nitropyrimidine 96% 1920-66-7 5g $116 2026-06-04 Buy
Product number Packaging Price Buy
720321 1g $211 Buy
720321 250mg $74 Buy
OR471127 250mg $21 Buy
OR471127 1g $25 Buy
OR471127 5g $116 Buy

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Chemical Properties,Uses,Production

Chemical Properties

Yellow to brown solid

Uses

It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Synthesis

2,4-Dichloro-5-nitropyrimidine

49845-33-2

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE

1920-66-7

General procedure for the synthesis of 2-chloro-4-amino-5-nitropyrimidines from 2,4-dichloro-5-nitropyrimidines: a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) was slowly added dropwise to a solution of 2,4-dichloro-5-nitropyrimidines (30 g, 154.36 mmol) in dichloromethane (DCM) with ammonia (NH3-H2O, aqueous solution, 24 mL) and N,N-diisopropylethylamine ( DIPEA, 37.2 mL) to a mixed solution of DCM (400 mL). The reaction mixture was stirred continuously at 0 °C for 1 h, followed by filtration. The collected solid was dried to give the target product 2-chloro-4-amino-5-nitropyrimidine (25 g, 92.6% yield) as a yellow solid. It was analyzed by liquid chromatography-mass spectrometry (LCMS, ESI) and m/z: 175.0 ([M+H]+) was measured.

References

[1] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 0541-0542
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10685 - 10699
[3] Patent: EP2578584, 2013, A1. Location in patent: Paragraph 0071; 0072
[4] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 2, p. 321 - 328
[5] Patent: EP3284743, 2018, A1. Location in patent: Paragraph 0135

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

5-Nitrouracil Ammonium hydroxide Phosphorus oxitrichloride Phosphorus trichloride Nitric acid
Uracil N,N-Diethylaniline Ammonia 2,4-Dichloro-5-nitropyrimidine N,N-Diisopropylethylamine

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Preparation Products

2-Chloro-4,5-diaminopyrimidine 2-Methoxy-5-Nitro-4-Pyrimidinamine N-methyl-5-nitro-pyrimidine-2,4-diamine

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Suppliers

Global( 139)Suppliers
Supplier Tel Email Country ProdList Advantage
Fuyang JSK Biomedical Technology Co., Ltd 18915409046 1102409417@qq.com China 203 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
ZEROSCHEM.CO.,LTD. 10-61256048 13810278579; sales@zeroschem.com China 1399 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Fuyang JSK Biomedical Technology Co., Ltd 55
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Longsheng chemical Co.,Ltd. 59
ZEROSCHEM.CO.,LTD. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE pictures 2026-08-20 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-CHLORO-5-NITROPYRIMIDIN-4-AMINE pictures 2020-01-09 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE
1920-66-7
 $6.68 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE Spectrum

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE(1920-66-7)MS2-CHLORO-5-NITROPYRIMIDIN-4-AMINE(1920-66-7)1HNMR2-CHLORO-5-NITROPYRIMIDIN-4-AMINE(1920-66-7)IR12-CHLORO-5-NITROPYRIMIDIN-4-AMINE(1920-66-7)IR2

1920-66-7(2-CHLORO-5-NITROPYRIMIDIN-4-AMINE)Related Search:

2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-Chloro-5-nitropyrimidine 6-Chloro-5-nitropyrimidin-4-amine 2-chloro-N-methyl-5-nitropyrimidin-4-amine 4-AMINO-2-CHLORO-6-METHYL-5-NITROPYRIMIDINE
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE 6-Chloro-5-nitropyrimidin-4-amine ,95% IFLAB-BB F2124-0162 N4,6-DIMETHYL-N4-PHENYL-2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 4-AMINO-2-CHLORO-5-NITRO-6-PIPERIDIN-1-YLPYRIMIDINE
IFLAB-BB F2124-0143 CHEMBRDG-BB 5145935 2-CHLORO-5-NITRO-4-METHYL-6-(METHYLAMINO)PYRIMIDINE IFLAB-BB F2124-0156 IFLAB-BB F2124-0157
IFLAB-BB F2124-0161 4-(6-Amino-2-chloro-5-nitro-4-pyrimidinyl)morpholine IFLAB-BB F2124-0144

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IFLAB-BB F1930-0037 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE 2-CHLORO-5-NITRO-4-PYRIMIDINAMINE 4-Pyrimidinamine, 2-chloro-5-nitro- 2-Chloro-5-nitropyrimidin-4-amine ,95% 2-Chloro-5-nitro-6-aminopyrimidine 2-Chloro-5-nitropyrimidine-4-amine (2-chloro-5-nitro-pyrimidin-4-yl)amine 4-amino-5-nitro-2-chloropyrimidine 2-Chloro-4-aMino-5-nitropyriMidine 2-chloro-5-nitropyriMidine-4-aMino 1-(2-prop-2-enoxyethoxy)butane 2-Chloro-5-nitropirimidin-4-amine 2-CHLORO-5-NITROPYRIMIDIN-4-AMINE ISO 9001：2015 REACH KML-51 nitropyrimidin-​ 4-AMINO-2-CHLORO-5-NITROPYRIMIDINE 1920-66-7 20-66-7 C4H3ClN4O2 pharmacetical