ChemicalBook >> CAS DataBase List >>16-Hydroxyhexadecanoic acid

16-Hydroxyhexadecanoic acid

CAS No.
506-13-8
Chemical Name:
16-Hydroxyhexadecanoic acid
Synonyms
16-HYDROXYPALMITIC ACID;JUNIPERIC ACID;16-hydroxy-hexadecanoicaci;junipericaci;16-HYDROXYHEXADECANOI;16-hydroxyhexadecanoate;Lactic Acid Impurity 124;16-Hydroxyhexadecanoic acid;16-HydroxyhexadecanoicAcid>Hexadecanoic acid, 16-hydroxy-
CBNumber:
CB1488018
Molecular Formula:
C16H32O3
Molecular Weight:
272.42
MDL Number:
MFCD00002750
MOL File:
506-13-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:49:17

16-Hydroxyhexadecanoic acid Properties

Melting point 94-98 °C(lit.)
Boiling point 414.4±18.0 °C(Predicted)
Density 0.956±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 2.5 mg/ml
form Crystalline Powder
pka 4.78±0.10(Predicted)
color White
BRN 1783998
InChI InChI=1S/C16H32O3/c17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16(18)19/h17H,1-15H2,(H,18,19)
InChIKey UGAGPNKCDRTDHP-UHFFFAOYSA-N
SMILES C(O)(=O)CCCCCCCCCCCCCCCO
LogP 4.904 (est)
CAS DataBase Reference 506-13-8(CAS DataBase Reference)
FDA UNII 7IPP3U0F3I
EPA Substance Registry System 16-Hydroxypalmitic acid (506-13-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Risk Statements  36/37/38
Safety Statements  22-24/25
WGK Germany  3
TSCA  TSCA listed
HS Code  29181998
Storage Class 11 - Combustible Solids
NFPA 704
0
0 0

16-Hydroxyhexadecanoic acid price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 177490 16-Hydroxyhexadecanoic acid 98% 506-13-8 1g $83 2026-04-30 Buy
Sigma-Aldrich 177490 16-Hydroxyhexadecanoic acid 98% 506-13-8 5g $254 2026-04-30 Buy
TCI Chemical H0675 16-Hydroxyhexadecanoic Acid >98.0%(T) 506-13-8 1g $77 2026-04-30 Buy
TCI Chemical H0675 16-Hydroxyhexadecanoic Acid >98.0%(T) 506-13-8 5g $379 2026-04-30 Buy
Cayman Chemical 9000789 16-hydroxy Hexadecanoic Acid ≥98% 506-13-8 1g $52 2026-04-30 Buy
Product number Packaging Price Buy
177490 1g $83 Buy
177490 5g $254 Buy
H0675 1g $77 Buy
H0675 5g $379 Buy
9000789 1g $52 Buy

16-Hydroxyhexadecanoic acid Chemical Properties, Uses, Production

Description

16-hydroxy Hexadecanoic acid is a metabolite of the saturated fatty acid palmitic acid (16:0) that has been hydroxylated on its terminal (ω) carbon. It is produced by ω-hydroxylation of palmitic acid by cytochrome P450 in both plants and animals. In plants, it is commonly a component of cutin.

Chemical Properties

white crystalline solid

Uses

16-Hydroxyhexadecanoic acid was used in the synthesis of dihydroxypalmitic acids. It was also used to induce the expression of two GRP genes of Arabidopsis thaliana, AtGRP5 and AtGRP23.

Definition

ChEBI: 16-hydroxyhexadecanoic acid is an omega-hydroxy-long-chain fatty acid that is hexadecanoic acid (also known as palmitic acid) which is substituted at position 16 by a hydroxy group. It is a key monomer of cutin in the plant cuticle. It has a role as a plant metabolite. It is an omega-hydroxy-long-chain fatty acid and a hydroxypalmitic acid. It is a conjugate acid of a 16-hydroxyhexadecanoate.

Application

16-Hydroxyhexadecanoic acid can be used to:
(1) Oxidative reactions: Cell lysates and intact cells of Escherichia coli JM101 recombinant, which synthesises the cyp102 gene for cytochrome P450BM-3 monooxygenase, biotransform 16-hydroxyhexa-decanoic acid into 1, 16-hexadecanedioic acid. a small amount of intermediate product accumulation accompanies the oxidation of 16-hydroxyhexadecanoic acid. hydroxyhexadecanoic acid oxidation is accompanied by the accumulation of a small amount of intermediate products. The by-products also include 13.16-dihydroxyhexadecanoic acid and 12,16-dihydroxyhexadecanoic acid[1].
(2) 16-hydroxyhexadecanoic acid ethyl ester was synthesised from 16-hexadecanolactone by an intramolecular ester exchange reaction with PEG-lipase[2].
(3) Lactonisation reaction: It has been demonstrated that Mucor javanicus L46 and Mucor miehei catalyse the lactonisation reaction of 15-hydroxypentadecanoic and 16- hydroxyhexadecanoic acids to appropriate macrocyclic mono- and oligolactones[3].

References

[1] S. SCHNEIDER. Production Of Alkanedioic Acids By Cytochrome P450Bm-3 Monooxygenase: Oxidation Of 16-Hydroxyhexadecanoic Acid To Hexadecane-1, 16-Dioic Acid[J]. Biocatalysis and Biotransformation, 1999. DOI:10.3109/10242429909040113.
[2] YOH KODERA . Lactone synthesis from 16-hydroxyhexadecanoic acid ethyl ester in organic solvents catalyzed with polyethylene glycol-modified lipase[J]. Journal of biotechnology, 1993. DOI:10.1016/0168-1656(93)90162-G.
[3] U. ANTCZAK . Enzymatic lactonization of 15-hydroxypentadecanoic and 16-hydroxyhexadecanoic acids to macrocyclic lactones[J]. Enzyme and Microbial Technology, 1991. DOI:10.1016/0141-0229(91)90095-R.

109-29-5
506-13-8
Synthesis of 16-Hydroxyhexadecanoic acid from 16-Hexadecanolide
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View Latest Price from 16-Hydroxyhexadecanoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
16-HYDROXYHEXADECANOIC ACID pictures 2026-09-02 16-HYDROXYHEXADECANOIC ACID
506-13-8
$1.00-50.00 1KG 99% Henan Fengda Chemical Co., Ltd
16-hydroxy Hexadecanoic Acid pictures 2026-05-11 16-hydroxy Hexadecanoic Acid
506-13-8
$29.00 99.82% 10g TargetMol Chemicals Inc.
16-Hydroxyhexadecanoic acid pictures 2025-06-27 16-Hydroxyhexadecanoic acid
506-13-8
$10.00-30.00 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
Hexadecanoic acid, 16-hydroxy- 16-Hydroxyhexadecanoic acid, 97+% 16-Hydroxyhexadecanoicacid,98% 16-Hydroxypalmitic acid, Juniperic acid 16-hydroxyhexadecanoate 16-HydroxyhexadecanoicAcid> junipericaci 16-HYDROXYHEXADECANOI Lactic Acid Impurity 124 16-hydroxy-hexadecanoicaci 16-HYDROXYPALMITIC ACID JUNIPERIC ACID 16-Hydroxyhexadecanoic acid 506-13-8 HOCH2CH214COOH C16H32O3 HOCH215CO2H 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides 蠅-Hydroxycarboxylic Acids Building Blocks C13 to C42+ Carbonyl Compounds Carboxylic Acids Organic Building Blocks omega-Functional Alkanols, Carboxylic Acids, Amines & Halides omega-Hydroxycarboxylic Acids Biochemicals and Reagents Building Blocks C13 to C42+ Carbonyl Compounds Carboxylic Acids Chemical Synthesis Fatty Acids and conjugates Fatty Acyls Hydroxy Fatty Acids Lipids Organic Building Blocks