ChemicalBook >> CAS DataBase List >>3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one structure

CAS No.: 7416-34-4

Chemical Name:: 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

Synonyms: MOLINDONE;C07230;EN-1733A;EOS-60951;Molintone;Molindonum;indol-4(5h)-one;MOLINDONE USP/EP/BP;3-Ethyl-2-Methyl-5-(Morpholin-4-ylMethyl)-1,5,6,7-;3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one

CBNumber:: CB1497074

Molecular Formula:: C16H24N2O2

Molecular Weight:: 276.37

MDL Number:: MFCD00866709

MOL File:: 7416-34-4.mol

MSDS File:: SDS

Last updated:2026-09-10 08:17:50

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3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Properties

Melting point	180-181°
Boiling point	462.9±45.0 °C(Predicted)
Density	1.140±0.06 g/cm3(Predicted)
solubility	H₂O: 19 mg/mL
form	solid
pka	pKa 6.9(H2O,t =25,I=0.2) (Uncertain)
color	off-white
CAS DataBase Reference	7416-34-4(CAS DataBase Reference)
FDA UNII	RT3Y3QMF8N
NIST Chemistry Reference	Indol-4(5h)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-(7416-34-4)
ATC code	N05AE02

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xn
Risk Statements	22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	NM3325000
Hazardous Substances Data	7416-34-4(Hazardous Substances Data)

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0028466	Molindone 98%	7416-34-4	1mg	$379	2026-06-04	Buy
ChemScene	CS-0028466	Molindone 98%	7416-34-4	5mg	$1137	2026-06-04	Buy
ChemScene	CS-0028466	Molindone 98%	7416-34-4	10mg	$1813	2026-06-04	Buy
Ambeed	A387446	Molindone 95%	7416-34-4	50mg	$589	2026-06-05	Buy
Ambeed	A387446	Molindone 95%	7416-34-4	100mg	$708	2026-06-05	Buy

Product number	Packaging	Price	Buy
CS-0028466	1mg	$379	Buy
CS-0028466	5mg	$1137	Buy
CS-0028466	10mg	$1813	Buy
A387446	50mg	$589	Buy
A387446	100mg	$708	Buy

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Chemical Properties,Uses,Production

Originator

Moban,Endo,US,1974

Uses

Molindone is a more active antipsychotic than chloropromzine. Its sedative effect is less expressed. Side effects are also expressed less than with powerful neuroleptics. It facilitates the reduction of spontaneous movements and aggressiveness, and is used for treatment of psychotic disturbances, particularly in cases of chronic and severe schizophrenia.

Uses

Antipsychotic.

Definition

ChEBI: Molindone is a member of indoles.

Manufacturing Process

Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2- methyl-4-oxoindole.
3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol) were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to dryness in vacuo on a steam bath and the residue digested with a mixture of 150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting material was filtered off. To the acid solution, ammonia water was added dropwise with stirring and the amine crystallized out. It was purified by dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl- 4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.

brand name

Moban (Endo).

Therapeutic Function

Antipsychotic

Side effects

Molindone hydrochloride, a tetrahydro-indolone derivative, is a neuroleptic agent that is structurally unrelated to any of the other marketed neuroleptics. Molindone is less potent than haloperidol at blocking D2 receptors; however, it nonetheless can produce extrapyramidal side effects.

Synthesis

Molindone, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)- one (6.4.3), is synthesized by the nitrozation of diethylketone using nitric acid or methylnitrite into nitrozodiethylketone (6.4.1). Reduction of this product with zinc in acetic acid into 2-aminodiethylketone in the presence of cyclohexandion-1,3 gives 3-ethyl-2-methyl- 4,5,6,7-tetrahydroindol-4-one (6.4.2). Aminomethylation of this product using morpholine and formaldehyde gives molindone (6.4.3) [51¨C52].

Synthesis_7416-34-4

Metabolism

Metabolism studies in humans show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites, with less than 2 to 3% unmetabolized molindone being excreted in urine and feces. Clinical studies show that the antipsychotic effects of molindone last more than 24 hours, suggesting that one or more metabolites may contribute to its activity in vivo (62).

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Preparation Products And Raw materials

Raw materials

3-Pentanone Paraformaldehyde Nitrous acid methyl ester Bis(4-hydroxyphenyl) Sulfone Morpholinium chloride

Preparation Products

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Jinan elephant international trading co., LTD		13006575422@163.com	China	6347	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58

Supplier	Advantage
XiaoGan ShenYuan ChemPharm co,ltd	52
BOC Sciences	65
HBCChem, Inc.	60
Shanghai YuLue Chemical Co., Ltd.	55
Jinan elephant international trading co., LTD	58
Capot Chemical Co.,Ltd.	60
TargetMol Chemicals Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58

View Lastest Price from 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-10	Molindone 7416-34-4	$210.00-678.00		99.67%	10g	TargetMol Chemicals Inc.
	2019-12-25	3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one 7416-34-4	$1.00	1KG	85.0-99.8%	20 tons	Career Henan Chemical Co

Molindone
7416-34-4
$210.00-678.00
99.67%
TargetMol Chemicals Inc.

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
7416-34-4
$1.00
85.0-99.8%
Career Henan Chemical Co

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Spectrum

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one(7416-34-4)¹HNMR

7416-34-4(3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one)Related Search:

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1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE INULIN MOLINDONE HCL MOLINDONE HYDROCHLORIDE 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

3-ethyl-2-methyl-4,5,6,7-tetrahydroindol-4-one MOLINDONE HYDROCHLORIDE (500 MG)

1of3

3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4h-indol-4-on 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4h-indol-4-one 3-Ethyl-2-methyl-6-(4-morpholinylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-indol-4(5h)-on 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one EN-1733A indol-4(5h)-one C07230 3-Ethyl-2-Methyl-5-(Morpholin-4-ylMethyl)-1,5,6,7- 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-Methyl-5-(4-MorpholinylMethyl)- 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydro-4H-indol-4-one EOS-60951 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one MOLINDONE USP/EP/BP 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one USP/EP/BP Molindonum Molintone 3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one MOLINDONE 7416-34-4