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ChemicalBook >> CAS DataBase List >>1,5,6,7-Tetrahydro-4H-indol-4-one

1,5,6,7-Tetrahydro-4H-indol-4-one

1,5,6,7-Tetrahydro-4H-indol-4-one Structure
1,5,6,7-Tetrahydro-4H-indol-4-one structure
CAS No.
13754-86-4
Chemical Name:
1,5,6,7-Tetrahydro-4H-indol-4-one
Synonyms
4,5,6,7-Tetrahydro-4-oxoindole;6,7-dihydro-1H-indol-4(5H)-one;NSC 131681;Tetrahydroindolone;4-0xo-4,5,6,7-tetr;1,5,6,7-Tetrahydro-4H<;6,7-Dihydroindol-4(5H)-one;4,5,6,7-Tetrahydro-4-indolone;4-0xo-4,5,6,7-tetrahydroindole;4-Oxo-1,5,6,7-tetrahydroindole
CBNumber:
CB7265060
Molecular Formula:
C8H9NO
Molecular Weight:
135.16
MDL Number:
MFCD00075438
MOL File:
13754-86-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:53
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1,5,6,7-Tetrahydro-4H-indol-4-one Properties

Melting point 188-190 °C (lit.)
Boiling point 311℃
Density 1.216
Flash point 150℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form powder to crystal
pka 15.91±0.20(Predicted)
color White to Light yellow to Light orange
InChI InChI=1S/C8H9NO/c10-8-3-1-2-7-6(8)4-5-9-7/h4-5,9H,1-3H2
InChIKey KASJZXHXXNEULX-UHFFFAOYSA-N
SMILES N1C2=C(C(=O)CCC2)C=C1
CAS DataBase Reference 13754-86-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HS Code  2914390090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

1,5,6,7-Tetrahydro-4H-indol-4-one price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 357839 1,5,6,7-Tetrahydro-4H-indol-4-one 98% 13754-86-4 5g $45.6 2026-04-30 Buy
TCI Chemical T1435 1,5,6,7-Tetrahydro-4H-indol-4-one >99.0%(GC) 13754-86-4 5g $18 2026-04-30 Buy
TCI Chemical T1435 1,5,6,7-Tetrahydro-4H-indol-4-one >99.0%(GC) 13754-86-4 25g $53 2026-04-30 Buy
Biosynth FD155332 6,7-Dihydro-1H-indol-4(5H)-one 13754-86-4 10g $188.4 2026-06-04 Buy
Biosynth FD155332 6,7-Dihydro-1H-indol-4(5H)-one 13754-86-4 25g $392.75 2026-06-04 Buy
Product number Packaging Price Buy
357839 5g $45.6 Buy
T1435 5g $18 Buy
T1435 25g $53 Buy
FD155332 10g $188.4 Buy
FD155332 25g $392.75 Buy

1,5,6,7-Tetrahydro-4H-indol-4-one Chemical Properties, Uses, Production

Uses

• ;Reactant in synthesis of psammopemmin A as antitumor agent1• ;Reactant in synthesis of a 1,3,4,5-tetrahydrobenzindole β-ketoesters and tricyclic tetrahydrobenzindoles via C-H insertion reactions2• ;Reactant in preparation of tricyclic indole and dihydroindole derivatives as inhibitors of guanylate cyclase3• ;Reactant in preparation of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of (halobenzyl)pyrroles4• ;Reactant in enantioselective preparation of arylalkenyl indoles via asymmetric C-H insertion of rhodium carbenoids foll

Uses

1,5,6,7-Tetrahydro-4H-indol-4-one, is a versatile building block used for the synthesis of more complex pharmaceutical compounds. It can be used for the preparation of Psammopemmin A.

General Description

Iodination of 1,5,6,7-tetrahydro-4H-indol-4-one using 1-chloromethyl--4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetra-fluoroborate) yields α-iodo derivative as the main product.

Synthesis

6,7-Dihydro-4(5H)-benzofuranone

16806-93-2

1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE

13754-86-4

The general procedure for the synthesis of 1,5,6,7-tetrahydro-4H-indol-4-one from 6,7-dihydro-4(5H)-benzofuranone is as follows: 6,7-dihydro-4(5H)-benzofuranone (0.10 g, 0.73 mmol) was dissolved in 20% aqueous ethanol (ca. 2 mL) along with the corresponding amine (3 equiv.) in an airtight tube at 150°C, respectively, and was Heating for 12 h or 36 h, respectively. Upon completion of the reaction, the reaction mixture was poured into water (10 mL) and the resulting aqueous solution was extracted with dichloromethane (3 x 10 mL). The organic extracts were combined, dried with anhydrous magnesium sulfate and concentrated to give a brown residue. This residue was purified by silica gel column chromatography with a solvent mixture of ethyl acetate/petroleum ether as eluent.

References

[1] Heterocycles, 1984, vol. 22, # 10, p. 2313 - 2316
[2] Tetrahedron Letters, 2012, vol. 53, # 33, p. 4276 - 4279
[3] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 1, p. 341 - 343

1,5,6,7-Tetrahydro-4H-indol-4-one Preparation Products And Raw materials

Raw materials

Ethyl bromopyruvate Resorcinol 2-Cyclohexen-1-one, 3-[(2-hydroxyethyl)amino]- 6,7-Dihydro-4(5H)-benzofuranone 4(2H)-Benzofuranone, 2-ethoxy-3,5,6,7-tetrahydro-
1,3-Cyclohexanedione, 2-(2,2-diethoxyethyl)- Water Ethanol Ammonia

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Preparation Products

1,5,6,7-Tetrahydro-4H-indol-4-one Suppliers

Global Suppliers ( 175)
Supplier Tel Email Country ProdList Advantage
Jinan Yaode Biotechnology Co., Ltd 17805033575; 17805033575 baiyu1.618@163.com China 391 58
PSN Pharmaceutical Technology Co., Ltd. 18136588612 sales@jspsn.com China 70 58
Hubei Deli Pharmaceutical Technology Co., Ltd 13372285931 19237964946 dl@delipharm.com China 107 58
Shanghai Enong Biotechnology Co., LTD 15821616017 2507465308@qq.com China 89 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Supplier Advantage
Jinan Yaode Biotechnology Co., Ltd 58
PSN Pharmaceutical Technology Co., Ltd. 58
Hubei Deli Pharmaceutical Technology Co., Ltd 58
Shanghai Enong Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Carbott PharmTech Inc. 56

View Latest Price from 1,5,6,7-Tetrahydro-4H-indol-4-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE pictures 2026-08-25 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE
13754-86-4
 $85.00-850.00 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE pictures 2025-04-04 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE
13754-86-4
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE pictures 2019-08-30 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE
13754-86-4
 $1.00 1KG 95%-99% 100KG Career Henan Chemical Co

1,5,6,7-Tetrahydro-4H-indol-4-one Spectrum

1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE(13754-86-4)MS1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE(13754-86-4)1HNMR1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE(13754-86-4)13CNMR1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE(13754-86-4)IR11,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE(13754-86-4)IR2

13754-86-4 (1,5,6,7-Tetrahydro-4H-indol-4-one) Related Search:

3-Ethyl-2-methyl-6-(4-morpholinylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one 1,2,3,9-Tetrahydro-4(H)-carbazol-4-one 1,5,6,7-Tetrahydro-4H-indol-4-one 1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one 1,5,6,7-Tetrahydro-2-methyl-4H-indol-4-one
3-ethyl-2-methyl-4,5,6,7-tetrahydroindol-4-one 2,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indol-4-one 1-(4-Methoxyphenyl)-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 1-(4-Methylphenyl)-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 1-(3,5-Bis(trifluoromethyl)phenyl)-2-(4-bromophenyl)-6,6-dimethyl-5,6,7-trihydroindol-4-one
1-(3-Methoxyphenyl)-2,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indol-4-one 1-(3-Chlorophenyl)-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 2-(4-Fluoro-3-methylphenyl)-6,6-dimethyl-5,6,7-trihydroindol-4-one 2-Methyl-1,2,3,9-tetrahydro-carbazol-4-one 2-(4-Bromophenyl)-1-(4-chlorophenyl)-6,6-dimethyl-5,6,7-trihydroindol-4-one
5-[(Dimethylamino)methylene]-1-(4-methylphenyl)-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 1-(4-Chlorophenyl)-2-phenyl-1,5,6,7-tetrahydro-4H-indol-4-one 1,2-Diphenyl-1,5,6,7-tetrahydro-4H-indol-4-one

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4-Oxo-1,5,6,7-tetrahydroindole 1,5,6,7-TETRAHYDRO-4H-INDOLE-4-ONE 1,5,6,7-TETRAHYDRO-INDOL-4-ONE 4-OXO-4,5,6,7-TETRAHYDROINDOLE Tetrahydroindolone 4-0xo-4,5,6,7-tetrahydroindole 1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONE 97+% 6,7-Dihydroindol-4(5H)-one 4-0xo-4,5,6,7-tetr 4-Oxo-4,5,6,7-tetrahydro-1H-indole 4,5,6,7-Tetrahydro-4-indolone NSC 131681 4,5,6,7-Tetrahydro-1H-indol-4-one 1,7-Dihydro-pyrano[3,4-b]pyrrol-4-one 4H-Indol-4-one, 1,5,6,7-tetrahydro- 1,5,6,7-Tetrahydro-4H-indol-4-one 1,5,6,7-tetrahydro-1H-indol-4-one 1,5,6,7-Tetrahydro-4H< 1,5,6,7-tetrahydro-4-H-indole-4-one 97% 4,5,6,7-Tetrahydro-4-oxoindole 6,7-dihydro-1H-indol-4(5H)-one 1,5,6,7-Tetrahydro-4H-indol-4-one 13754-86-4 Indoles Heterocyclic Building Blocks KETONE Building Blocks Building Blocks C7 to C9 Chemical Synthesis Heterocyclic Building Blocks Heterocyclic Building Blocks Indoles Building Blocks Heterocyclic Compounds